Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N129972-5mg | 5mg | In stock | $129.90 | |
N129972-25mg | 25mg | In stock | $585.90 | |
N129972-50mg | 50mg | In stock | $854.90 |
Potent p53-MDM2 binding inhibitor
Synonyms | (-)-Nutlin-3 | CS-0296 | Nutlin-3a, >=98% (HPLC) | REBEMADLIN [INN] | Z2037279564 | (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | SML-0580 | AKOS027422740 | 2-Piperazinone, 4-(((4S,5R |
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Specifications & Purity | ≥97% |
Biochemical and Physiological Mechanisms | Nutlin-3a [(-)-Nutlin] is a more potent diasteromer of nutlin-3, a racemic MDM2 antagonist. It is called enantiomer A because it will serve as the first peak elution of racemic Nutlin-3 chiral purification. Nutlin-3a is a potent inhibitor of MDM2 (murine |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Cellular tumor antigen p53 exogenous gene | EXOGENOUS GENE | ALA4096 | Cellular tumor antigen p53 | SINGLE PROTEIN | Homo sapiens | ||
Cellular tumor antigen p53 stabiliser | STABILISER | ALA4096 | Cellular tumor antigen p53 | SINGLE PROTEIN | Homo sapiens | ||
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | FDA: [1] | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | BH3 binding groove | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | Occupies the BH3 binding groove of Bcl-xL, Bcl-2, and Bcl-w. | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor | INHIBITOR | ALA4361 | Induced myeloid leukemia cell differentiation protein Mcl-1 | SINGLE PROTEIN | Homo sapiens | ||
Tumour suppressor p53/oncoprotein Mdm2 inhibitor | INHIBITOR | ALA1907611 | Tumour suppressor p53/oncoprotein Mdm2 | PROTEIN-PROTEIN INTERACTION | Homo sapiens | ||
Tumour suppressor p53/oncoprotein Mdm2 inhibitor | INHIBITOR | ALA1907611 | Tumour suppressor p53/oncoprotein Mdm2 | PROTEIN-PROTEIN INTERACTION | Homo sapiens | ||
Tumour suppressor p53/oncoprotein Mdm2 inhibitor | INHIBITOR | ALA1907611 | Tumour suppressor p53/oncoprotein Mdm2 | PROTEIN-PROTEIN INTERACTION | Homo sapiens | PubMed: [1] |
Pubchem Sid | 504766412 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504766412 |
IUPAC Name | 4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one |
INCHI | InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1 |
InChi Key | BDUHCSBCVGXTJM-WUFINQPMSA-N |
Canonical SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
Isomeric SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
WGK Germany | 3 |
PubChem CID | 11433190 |
Molecular Weight | 581.49 |
Find and download the COA for your product by matching the lot number on the packaging.
4 results found
Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Jan 03, 2025 | N129972 | |
Certificate of Analysis | Jul 11, 2024 | N129972 | |
Certificate of Analysis | Jul 11, 2024 | N129972 | |
Certificate of Analysis | Jul 11, 2024 | N129972 |
Solubility | DMSO 100 mg/mL Water <1 mg/mL Ethanol 100 mg/mL |
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Specific Rotation[α] | [α]/D -130 to -154° (c=0.5, CDCl3) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |