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Nutlin-3a - ≥97%, high purity , CAS No.675576-98-4

≥97%

CAS#: 675576-98-4
Formula: C₃₀H₃₀Cl₂N₄O₄
Molecular Weight: 581.49
PubChem CID: 11433190

Item Number

N129972

Grouped product items
SKU	Size	Availability	Price
N129972-5mg	5mg	In stock	$129.90
N129972-25mg	25mg	In stock	$585.90
N129972-50mg	50mg	In stock	$854.90

Discover Nutlin-3a by Aladdin Scientific in ≥97% for only $129.90. Available - in Ligands at Aladdin Scientific. Potent p53-MDM2 binding inhibitor Tags: .

Basic Description

Synonyms	nutlin-3A\|675576-98-4\|Nutlin-3\|Nutlin 3a\|(-)-Nutlin-3\|Nutlin-3a chiral\|4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone\|4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-me
Specifications & Purity	≥97%
Storage Temp	Store at -20°C
Shipped In	Dry ice

Associated Targets

MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 31 Activities

Discover Target: MDM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 1 Activities

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
INCHI	InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
InChi Key	BDUHCSBCVGXTJM-WUFINQPMSA-N
Canonical SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Isomeric SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
WGK Germany	3
PubChem CID	11433190
Molecular Weight	581.49

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
I2222781	Certificate of Analysis	Jul 11, 2024	N129972
I2222782	Certificate of Analysis	Jul 11, 2024	N129972
I2222796	Certificate of Analysis	Jul 11, 2024	N129972

Solubility

DMSO 100 mg/mL Water <1 mg/mL Ethanol 100 mg/mL

Specific Rotation[α]

[α]/D -130 to -154° (c=0.5, CDCl3)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

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