Click Here for 5% Off Your First Aladdin Purchase!
Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

NVP-AUY922 - ≥98%, high purity , CAS No.747412-49-3, Inhibitor of heat shock protein 90 alpha family class B member 1;Inhibitor of TNF receptor associated protein 1

  • Moligand™
  • ≥98%
Item Number
N126962
Grouped product items
SKUSizeAvailabilityPrice Qty
N126962-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
N126962-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
N126962-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
N126962-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
N126962-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$362.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET
View related series
heat shock protein 90 alpha family class B member 1 Inhibitor TNF receptor associated protein 1 Inhibitor

Basic Description

SynonymsLuminespib|747412-49-3|NVP-AUY922|AUY922|VER-52296|AUY-922|5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide|Luminespib (NVP-AUY922)|AUY922 (NVP-AUY922)|Luminespib (AUY-922 )|VER 52296|NVP-AUY 922|C6V1DAR5EB
Specifications & Purity≥98%
Biochemical and Physiological MechanismsNVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Tr
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of heat shock protein 90 alpha family class B member 1;Inhibitor of TNF receptor associated protein 1
Note25mg、10mg卖完停产，不再备货
Product Description

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
A highly potent HSP90 inhibitor to HSP90α and HSP90β

Product Properties

ALogP3.5

Associated Targets

HSP90B1 Tchem Endoplasmin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRAP1 Tchem Heat shock protein 75 kDa, mitochondrial 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSP90AB1 Tchem Heat shock protein HSP 90-beta 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
INCHI InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChi Key NDAZATDQFDPQBD-UHFFFAOYSA-N
Canonical SMILES CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Isomeric SMILES CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Alternate CAS 747412-49-3
PubChem CID 135539077
MeSH Entry Terms 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide;5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide;AUY922;luminespib;NVP-AUY922;VER 52296;VER-52296;V
Molecular Weight 465.54

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

1 results found

Lot NumberCertificate TypeDateItem
G1527056Certificate of AnalysisFeb 06, 2023 N126962

Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mg/mL), ethanol (100 mg/mL), and water (very poorly soluble).

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. AAPK-25 - 98%, used for , CAS No. 2247919-28-2, by Aladdin Scientific
    AAPK-25

    Starting at $180.90

  2. Z-VAD(OH)-FMK (Caspase Inhibitor VI) - 97%, used for , CAS No. 161401-82-7, by Aladdin Scientific
    Z-VAD(OH)-FMK (Caspase Inhibitor VI)

    Starting at $144.90

  3. SY-5609 - 99%, used for , CAS No. 2417302-07-7, by Aladdin Scientific
    SY-5609

    Starting at $440.90

  4. Dutasteride-¹³C6
    Dutasteride-¹³C6

    Starting at $554.90

References

1. Tao W, Chakraborty SN, Leng X, Ma H, Arlinghaus RB.  (2015)  HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells..  Genes Cancer,  6  (1-2): (19-29).  [PMID:25821558]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.