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NVP-AUY922 - ≥98%, high purity , CAS No.747412-49-3, Inhibitor of heat shock protein 90 alpha family class B member 1;Inhibitor of TNF receptor associated protein 1

Item Number
N126962
Grouped product items
SKUSizeAvailabilityPrice Qty
N126962-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
N126962-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
N126962-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
N126962-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
N126962-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$362.90
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heat shock protein 90 alpha family class B member 1 Inhibitor TNF receptor associated protein 1 Inhibitor

Basic Description

SynonymsAUY922 (NVP-AUY922) | NVP-AUY 922 | C6V1DAR5EB | VER-52296 | AUY922 | AUY-922 | VER 52296 | Luminespib (AUY-922 ) | 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide | Luminespib | Luminespib (NVP-AUY922)
Specifications & Purity≥98%
Biochemical and Physiological MechanismsNVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Tr
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of heat shock protein 90 alpha family class B member 1;Inhibitor of TNF receptor associated protein 1
Note25mg、10mg卖完停产，不再备货
Product Description

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
A highly potent HSP90 inhibitor to HSP90α and HSP90β

Product Properties

ALogP3.5

Associated Targets(Human)

HSP90B1 Tchem Endoplasmin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRAP1 Tchem Heat shock protein 75 kDa, mitochondrial (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSP90AB1 Tchem Heat shock protein HSP 90-beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
INCHI InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChi Key NDAZATDQFDPQBD-UHFFFAOYSA-N
Canonical SMILES CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Isomeric SMILES CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Alternate CAS 747412-49-3
PubChem CID 135539077
MeSH Entry Terms 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide;5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide;AUY922;luminespib;NVP-AUY922;VER 52296;VER-52296;V
Molecular Weight 465.54

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
G1527056Certificate of AnalysisFeb 06, 2023 N126962

Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mg/mL), ethanol (100 mg/mL), and water (very poorly soluble).

Related Documents

 SDS

 Specification Sheet

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References

1. Tao W, Chakraborty SN, Leng X, Ma H, Arlinghaus RB.  (2015)  HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells..  Genes Cancer,  6  (1-2): (19-29).  [PMID:25821558]

Solution Calculators

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