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NVP-AUY922 - ≥98%, high purity , CAS No.747412-49-3, Inhibitor of heat shock protein 90 alpha family class B member 1;Inhibitor of TNF receptor associated protein 1

Item Number
N126962
Grouped product items
SKUSizeAvailabilityPrice Qty
N126962-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
N126962-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
N126962-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
N126962-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
N126962-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$362.90
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Cell Cycle/DNA Damage heat shock protein 90 alpha family class B member 1 Inhibitor HSP Metabolic Enzyme/Protease TNF receptor associated protein 1 Inhibitor

Basic Description

SynonymsAUY922 (NVP-AUY922) | NVP-AUY 922 | C6V1DAR5EB | VER-52296 | AUY922 | AUY-922 | VER 52296 | Luminespib (AUY-922 ) | 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide | Luminespib | Luminespib (NVP-AUY922)
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsNVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Tr
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of heat shock protein 90 alpha family class B member 1;Inhibitor of TNF receptor associated protein 1
Note25mg、10mg卖完停产，不再备货
Product Description

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
A highly potent HSP90 inhibitor to HSP90α and HSP90β

Product Properties

ALogP3.5

Associated Targets(Human)

HSP90B1 Tchem Endoplasmin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRAP1 Tchem Heat shock protein 75 kDa, mitochondrial (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSP90AB1 Tchem Heat shock protein HSP 90-beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
INCHI InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChi Key NDAZATDQFDPQBD-UHFFFAOYSA-N
Canonical SMILES CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Isomeric SMILES CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Alternate CAS 747412-49-3
PubChem CID 135539077
MeSH Entry Terms 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide;5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide;AUY922;luminespib;NVP-AUY922;VER 52296;VER-52296;V
Molecular Weight 465.54

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
G1527056Certificate of AnalysisNov 14, 2024 N126962
I2425558Certificate of AnalysisSep 02, 2024 N126962
I2425559Certificate of AnalysisSep 02, 2024 N126962

Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mg/mL), ethanol (100 mg/mL), and water (very poorly soluble).

Related Documents

 SDS

 Specification Sheet

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References

1. Tao W, Chakraborty SN, Leng X, Ma H, Arlinghaus RB.  (2015)  HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells..  Genes Cancer,  6  (1-2): (19-29).  [PMID:25821558] [10.1021/op500134e]

Solution Calculators

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