Basic Description

Synonyms	1,2-Benzenediamine \| Orthamine \| 2-Aminoaniline \| o-Benzenediamine \| benzene-1,2-diamine \| OPD \| 1,2-Phenylenediamine \| 1,2-Diaminobenzene \| o-Diaminobenzene
Specifications & Purity	Biochemical, ≥99%
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Grade	Biochemical

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)

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CASP7 Tchem Caspase-7 (0 Activities)

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RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)

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RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

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SMN1 Tchem Survival motor neuron protein (0 Activities)

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SNCA Tchem Alpha-synuclein (0 Activities)

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MMP9 Tchem Matrix metalloproteinase-9 (0 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 (0 Activities)

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CASP1 Tchem Caspase-1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AHR Tclin Aryl hydrocarbon receptor (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARG1 Tchem Arginase-1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen Receptor (11781 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CASP1 Tchem Caspase-1 (6235 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CASP7 Tchem Caspase-7 (3146 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DLD-1 (17511 Activities)

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DMS-273 (14108 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HOP-18 (11577 Activities)

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HOP-92 (41141 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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LXFL 529 (14112 Activities)

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Lymphoblastoid cell (5959 Activities)

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Associated Targets(non-human)

Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Serratia marcescens (3237 Activities)

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Bacillus subtilis (32866 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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ARG1 Arginase-1 (70 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

Discover Target: Nr1i2

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	benzene-1,2-diamine
INCHI	InChI=1S/C6H8N2/c7-5-3-1-2-4-6(5)8/h1-4H,7-8H2
InChi Key	GEYOCULIXLDCMW-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)N)N
Isomeric SMILES	C1=CC=C(C(=C1)N)N
WGK Germany	3
RTECS	SS7875000
PubChem CID	7243
UN Number	1673
Packing Group	III
Molecular Weight	108.14
Beilstein	606074
Reaxy-Rn	606074

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
I2413177	Certificate of Analysis	Aug 23, 2024	P103813
I2413178	Certificate of Analysis	Aug 23, 2024	P103813
I2413179	Certificate of Analysis	Aug 23, 2024	P103813
H2408069	Certificate of Analysis	May 15, 2024	P103813
A2219721	Certificate of Analysis	Aug 10, 2023	P103813
A2219722	Certificate of Analysis	Aug 10, 2023	P103813
A2219723	Certificate of Analysis	Jan 26, 2022	P103813
C2415090	Certificate of Analysis	Jan 26, 2022	P103813

Chemical and Physical Properties

Solubility	Soluble in water; Degree of Solubility in water: 41 g/l 35 °C; Very soluble in Alcohol,Ether,Chloroform; Soluble in Acetone,Benzene
Sensitivity	Light & Moisture & air sensitive
Flash Point(°F)	276.8 °F
Flash Point(°C)	136°C
Boil Point(°C)	256～258°C
Melt Point(°C)	103-104°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H301:Toxic if swallowed H341:Suspected of causing genetic defects H351:Suspected of causing cancer H317:May cause an allergic skin reaction H410:Very toxic to aquatic life with long lasting effects H312+H332:Harmful in contact with skin or if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3
RTECS	SS7875000
Reaxy-Rn	606074
Class	6.1
Merck Index	7284

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xinmei Zhao,Narayan S Hosmane,Aiguo Wu. (2012-11-13) ortho-Phenylenediamine: an effective spacer to build highly magnetic Fe3O4/Au nanocomposites.. Chemphyschem : a European journal of chemical physics and physical chemistry, 13 ((18)): (4142-4147). [PMID:23143847]
2. Lu Sun, Lin-Ge Chen, Hai-Bo Wang. (2024) Fenton-like reaction triggered chemical redox-cycling signal amplification for ultrasensitive fluorometric detection of H2O2 and glucose. ANALYST, 149 (2): (546-552). [PMID:38088105] [10.1039/D3AN01682J]
3. Die Xu, Junxiang Zhang, Zhenzhen Luo, Yanan Zhao, Yuanhua Zhu, Hualin Yang, Yu Zhou. (2024) Ratiometric fluorescence and absorbance dual-model immunoassay based on 2,3-diaminophenazine and carbon dots for detecting Aflatoxin B1. FOOD CHEMISTRY, 439 (138125). [PMID:38061303] [10.1016/j.foodchem.2023.138125]
4. Ziwei Lan, Tingting Li, Qiuning Li, Chenzhang Liu, Jia Li. (2024) Multifunctional glucose-powered nanomotors with robust dual enzyme mimic activities. SEPARATION AND PURIFICATION TECHNOLOGY, 333 (9): (125860). [PMID:17289582] [10.1016/j.seppur.2023.125860]
5. Yuan Fang, Shusen Ding, Weiran Li, Jingjing Zhang, Hui Sun, Xiaodong Lin. (2023) Dual-Channel Fluorescent/Colorimetric-Based OPD-Pd/Pt NFs Sensor for High-Sensitivity Detection of Silver Ions. Foods, 12 (23): (4260). [PMID:38231754] [10.3390/foods12234260]
6. Liping Shu, Heng Fang, Shichao Feng, Jianping Sun, Fang Yang, Dongying Hu, Fangchao Cheng. (2024) Assembling all-wood-derived carbon/carbon dots-assisted phase change materials for high-efficiency thermal-energy harvesters. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 256 (29): (128365). [PMID:38000615] [10.1016/j.ijbiomac.2023.128365]
7. Rui Chen, Jinjie You, Yuge Chen, Zeming Zhang, Aili Sun, Hua Liu, Xizhi Shi. (2024) Broad application prospects near-infrared carbonized polymer dots combined with machine learning for the detection of Cu2+ in seawater and aquatic products. SENSORS AND ACTUATORS B-CHEMICAL, 404 (135245). [PMID:] [10.1016/j.snb.2023.135245]
8. Nan Xu, Ting Pu, Lei Chen, Qin Yang, AnYuan Tong, FuBin Chen, ChunYan Yang. (2023) Synthesis of Nitrogen-Doped Carbon Quantum Dots (N-CQDs) as a Fluorescent Probe for the Determination of Tartrazine. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2297410]
9. Shen Zhang, Jinjia Bao, Ling Lv, Yongjie Bai, Yiming Zhang, Yaofang Zhang. (2024) Yellow-emitting carbon dots as fluorescent sensors for the rapid determination of curcumin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 309 (123819). [PMID:38157744] [10.1016/j.saa.2023.123819]
10. Ming Gao, Chang Bian, Hongjie Zhao, Huili Wang, Xuedong Wang. (2023) Assembling-fission synthesized fluorescent sulfur quantum dots combine with tyrosinase catalytic oxidation for selective detection of p-aminophenol in water samples. NEW JOURNAL OF CHEMISTRY, [PMID:] [10.1039/D3NJ04152B]
11. Yuanyuan Li, Shaorong Li, Yongli Wu, Yulong Ma, Wenxin Ji, Yonggang Sun, Keren Shi. (2024) Immobilization of two dendritic organic phases onto silica and their molecular shape recognition for polycyclic aromatic hydrocarbons, tocopherols and carotenoid isomers. ANALYTICA CHIMICA ACTA, 1288 (342156). [PMID:38220288] [10.1016/j.aca.2023.342156]
12. Haohan Wu, Yingchun Liu, Liheng Chen, Zhengwen Li, Zhaosong Hu, Xuliang Lin, Xueqing Qiu. (2023) Optimized Interface Structure of Degradable Epoxy Composites Based on the Self-Assembly of Lignin-Graphite for Thermal Management Application. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.3c06722]
13. Xinjing Li, Yishun Yao, Xue Xia, Foxin Zhang, Jingyang Yu, Heping Cui, Yunwei Niu, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho. (2023) Maillard Reaction Process and Characteristic Volatile Compounds Formed During Secondary Thermal Degradation Monitored via the Change of Fluorescent Compounds in the Reaction of Xylose–Corn Protein Hydrolysate. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38115213] [10.1021/acs.jafc.3c08082]
14. Bodong Wang, Shan Pu, Chengyan Xia, Xiandeng Hou, Kailai Xu. (2024) Enhancing peroxidase-like activity of AuNPs through headspace reaction: A signal amplification strategy for colorimetric and fluorescent sensing of trace Hg2+. ANALYTICA CHIMICA ACTA, 1287 (342132). [PMID:38182354] [10.1016/j.aca.2023.342132]
15. Yunjia Xu, Chao Huang, Shujuan Ma, Chunmiao Bo, Bolin Gong, Junjie Ou. (2024) Bifunctional fluorescent molecularly imprinted resin based on carbon dot for selective detection and enrichment of 2,4-dichlorophenoxyacetic acid in lettuce. FOOD CHEMISTRY, 439 (138167). [PMID:38071847] [10.1016/j.foodchem.2023.138167]
16. Yanqun Zhang, Yishun Yao, Tong Zhou, Foxin Zhang, Xue Xia, Jingyang Yu, Shiqing Song, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho. (2023) Light-Colored Maillard Peptides: Formation from Reduced Fluorescent Precursors of Browning and Enhancement of Saltiness Perception. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (50): (20251–20259). [PMID:38060299] [10.1021/acs.jafc.3c07476]
17. Wenteng Qiao, Luliang Wang, Kun Yang, Yushen Liu, Quanwen Liu, Feng Yin. (2023) A multichromatic colorimetric detection method for Vibrio parahaemolyticus based on Fe3O4-Zn-Mn nanoenzyme and dual substrates. Microbiology Spectrum, [PMID:38054716] [10.1128/spectrum.03189-23]
18. Yi Li, Xinze Wu, Hui Lyu, Huaixia Chen, Xueping Dang. (2024) Electrosynthesis of metal coordination cluster Zn5/polyaniline composite coating for headspace solid phase microextraction of nine volatile phenolic compounds in aqueous samples. MICROCHEMICAL JOURNAL, 197 (109775). [PMID:] [10.1016/j.microc.2023.109775]
19. Shipeng Jiang, Mingyang Sun, Peiran Meng, Xiaoyu Zhang, Yue Sun. (2023) Ultramicro and ultrasensitive detection of lipopolysaccharides based on triple-signal amplification via ultrafast ATRP and an ultramicroelectrode. ANALYST, 148 (24): (6359-6368). [PMID:37966725] [10.1039/D3AN01624B]
20. Zaofen Wang, Weiping Shi, Yunzhu Tan, Bingqian Liu. (2023) A homogeneous label-free electrochemical aptasensor based on an omega-like DNA nanostructure for progesterone detection. Analytical Methods, (19): [PMID:37955623] [10.1039/D3AY01255G]
21. Xingyuan Ma, Jianfeng Li. (2024) Preparation of multicolor carbon quantum dots by hydrothermal method and their functionalization applications. JOURNAL OF LUMINESCENCE, 266 (120296). [PMID:2183217] [10.1016/j.jlumin.2023.120296]
22. Shangying Qin, Li Huang, Dan Li, Zhongwei Lin, Chuang Wen, Yilin Wang. (2024) Colorimetric and fluorescent detection of glucose based on Fe7S8 nanosheets catalyzed oxidation of o-phenylenediamine. MICROCHEMICAL JOURNAL, 196 (109596). [PMID:18580862] [10.1016/j.microc.2023.109596]
23. Jinxin Li, Hao Zhang, Ling Zhu, Gangcheng Wu, Hui Zhang. (2023) Influence of in vitro gastrointestinal digestion and colonic fermentation on carbonyl scavenging capacity of fiber-bound polyphenols from quinoa. Food & Function, 14 (23): (10581-10590). [PMID:37955444] [10.1039/D3FO03000H]
24. Gao Lifang, Chen Rong, Li Haixia, Xu Dan, Zheng Danning. (2023) Time-resolved fluorescence nanoprobe of acetylcholinesterase based on ZnGeO:Mn luminescence nanorod modified with metal ions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (29): (7047-7055). [PMID:37889311] [10.1007/s00216-023-05007-9]
25. Xin Wang, Chengyi Hong, Zhengzhong Lin, Zhiyong Huang. (2024) A ratiometric fluorescent probe for hypoxanthine detection in aquatic products based on the enzyme mimics and fluorescence of cobalt-doped carbon nitride. Food Science and Human Wellness, 13 (879). [PMID:18063693] [10.26599/FSHW.2022.9250075]
26. Wenyuan Zhou, Yajie Li, Guoqiang Zhu, Xuechao Xu, Qin Hu, Zhenquan Yang, Xuewen Gu. (2024) High-sensitivity and high-specificity colorimetric detection of viable Staphylococcus aureus in ready-to-eat foods using a temperate-bacteriophage-based system with peroxidase-like activity. SENSORS AND ACTUATORS B-CHEMICAL, 399 (19): (134810). [PMID:11390979] [10.1016/j.snb.2023.134810]
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o-Phenylenediamine - 99%,for Biochemical Research, high purity , CAS No.95-54-5

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