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O8 OGG1 Inhibitor - ≥98%(HPLC), high purity , CAS No.350997-39-6

≥98%(HPLC)

CAS#: 350997-39-6
Formula: C₉H₆Cl₂N₂OS
Molecular Weight: 261.13
PubChem CID: 874733
PubChem SID: 488191657

Item Number

O287618

Grouped product items
SKU	Size	Availability	Price
O287618-5mg	5mg	In stock	$60.90
O287618-10mg	10mg	In stock	$109.90
O287618-25mg	25mg	In stock	$261.90
O287618-50mg	50mg	In stock	$470.90
O287618-100mg	100mg	In stock	$846.90
O287618-250mg	250mg	In stock	$1,904.90

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Basic Description

Synonyms	AB00102917-01 \| AKOS003956278 \| BBL037375 \| Cambridge id 6132595 \| 3,4-dichlorobenzo[b]thiophene-2-carbohydrazide \| HY-112902 \| MFCD01993639 \| OGG1-IN-O8 \| 3,4-dichloro-1-benzothiophene-2-carbohydrazide \| O8 OGG1 Inhibitor- Bio-X \| OGG1-IN-08 \| OGG1 inhib
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50= 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

OGG1 Tchem N-glycosylase/DNA lyase (6 Activities)

Discover Target: OGG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OGG1 Tchem N-glycosylase/DNA lyase (81 Activities)

Discover Target: OGG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NTHL1 Tbio Endonuclease III-like protein 1 (51 Activities)

Discover Target: NTHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NEIL1 Tbio Endonuclease 8-like 1 (41 Activities)

Discover Target: NEIL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488191657
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488191657
IUPAC Name	3,4-dichloro-1-benzothiophene-2-carbohydrazide
INCHI	InChI=1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
InChi Key	HSSHUDKWJRJKPV-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl
Isomeric SMILES	C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl
PubChem CID	874733
Molecular Weight	261.13

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
C23281117	Certificate of Analysis	Jan 06, 2023	O287618
C23281118	Certificate of Analysis	Jan 06, 2023	O287618
C23281119	Certificate of Analysis	Jan 06, 2023	O287618
C23281120	Certificate of Analysis	Jan 06, 2023	O287618
C23281122	Certificate of Analysis	Jan 06, 2023	O287618
C23281123	Certificate of Analysis	Jan 06, 2023	O287618
C23281124	Certificate of Analysis	Jan 06, 2023	O287618
C23281125	Certificate of Analysis	Jan 06, 2023	O287618
C2329381	Certificate of Analysis	Jan 06, 2023	O287618
C2329382	Certificate of Analysis	Jan 06, 2023	O287618
C2329410	Certificate of Analysis	Jan 06, 2023	O287618
C2329597	Certificate of Analysis	Jan 06, 2023	O287618

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