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O8 OGG1 Inhibitor - 10mM in DMSO, high purity , CAS No.350997-39-6

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O8 OGG1 Inhibitor - 10mM in DMSO, high purity , CAS No.350997-39-6

10mM in DMSO

CAS#: 350997-39-6
Formula: C₉H₆Cl₂N₂OS
Molecular Weight: 261.13
PubChem CID: 874733

Item Number

O423560

Grouped product items
SKU	Size	Availability	Price	Qty
O423560-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Basic Description

Synonyms	3,4-dichloro-1-benzothiophene-2-carbohydrazide \| 350997-39-6 \| O8 OGG1 Inhibitor \| 3,4-dichlorobenzo[b]thiophene-2-carbohydrazide \| OGG1-IN-O8 \| OGG1 inhibitor O8 \| OGG1-IN-08 \| 3,4-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide \| CBMicro_031749 \| Cambridge id 6132
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50= 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

OGG1 Tchem N-glycosylase/DNA lyase (6 Activities)

Discover Target: OGG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OGG1 Tchem N-glycosylase/DNA lyase (81 Activities)

Discover Target: OGG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NTHL1 Tbio Endonuclease III-like protein 1 (51 Activities)

Discover Target: NTHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

mutM Formamidopyrimidine-DNA glycosylase (36 Activities)

Discover Target: mutM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3,4-dichloro-1-benzothiophene-2-carbohydrazide
INCHI	InChI=1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
InChi Key	HSSHUDKWJRJKPV-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl
Isomeric SMILES	C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl
PubChem CID	874733
Molecular Weight	261.13

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