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Obatoclax (GX15-070) - 98%, high purity , CAS No.803712-67-6, Antagonist of BCL2 apoptosis regulator;Antagonist of Bcl-2-like 1;Antagonist of MCL1 apoptosis regulator; BCL2 family member

Moligand™
≥98%

CAS#: 803712-67-6
Formula: C₂₀H₁₉N₃O
Molecular Weight: 317.38
PubChem CID: 57353643

Item Number

O420059

Grouped product items
SKU	Size	Availability	Price
O420059-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90
O420059-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$241.90
O420059-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$732.90
O420059-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,060.90

View related series

Bcl-2-like 1 Antagonist BCL2 apoptosis regulator Antagonist MCL1 apoptosis regulator，BCL2 family member Antagonist

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Obatoclax (gx15-070) is a Bcl-2 antagonist with KI of 0.22 in cell-free test μ M. It can help to inhibit the anti apoptotic effect mediated by Mcl-1.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of BCL2 apoptosis regulator;Antagonist of Bcl-2-like 1;Antagonist of MCL1 apoptosis regulator; BCL2 family member

Associated Targets

MCL1 Tchem Induced myeloid leukemia cell differentiation protein Mcl-1 0 Activities

Discover Target: MCL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCL2 Tclin Apoptosis regulator Bcl-2 0 Activities

Discover Target: BCL2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCL2L1 Tchem Bcl-2-like protein 1 0 Activities

Discover Target: BCL2L1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole
INCHI	InChI=1S/C20H19N3O/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17/h4-11,21,23H,1-3H3
InChi Key	CVCLJVVBHYOXDC-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C
Isomeric SMILES	CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C
PubChem CID	57353643
Molecular Weight	317.38

PubChem CID

46930997

CAS Registry No.

803712-67-6

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
G2228054	Certificate of Analysis	Jun 05, 2022	O420059
G2228055	Certificate of Analysis	Jun 05, 2022	O420059
G2228056	Certificate of Analysis	Jun 05, 2022	O420059
G2228057	Certificate of Analysis	Jun 05, 2022	O420059

References

1. Han Z, Liang J, Li Y, He J. (2019) Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review.. Biomed Res Int, 2019 (3): (1212369). [PMID:31662966]
2. Cournoyer S, Addioui A, Belounis A, Beaunoyer M, Nyalendo C, Le Gall R, Teira P, Haddad E, Vassal G, Sartelet H. (2019) GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma.. BMC Cancer, 19 (1): (1018). [PMID:31664947]
3. Opydo-Chanek M, Cichoń I, Rak A, Kołaczkowska E, Mazur L. (2020) The pan-Bcl-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells.. Invest New Drugs, 38 (6): (1664-1676). [PMID:32367199]
4. Chen S, Ren Y, Duan P. (2020) Biomimetic nanoparticle loading obatoclax mesylate for the treatment of non-small-cell lung cancer (NSCLC) through suppressing Bcl-2 signaling.. Biomed Pharmacother, 129 (3): (110371). [PMID:32563984]
5. Ianevski A, Yao R, Fenstad MH, Biza S, Zusinaite E, Reisberg T, Lysvand H, Løseth K, Landsem VM, Malmring JF et al.. (2020) Potential Antiviral Options against SARS-CoV-2 Infection.. Viruses, 12 (6): (589-97). [PMID:32545799]

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