Grouped product items

SKU

Size

Availability

Price

Qty

O127017-10mg

10mg

Available within 4-8 weeks(?)

$129.90

O127017-50mg

50mg

Available within 4-8 weeks(?)

$347.90

O127017-100mg

100mg

Available within 4-8 weeks(?)

$626.90

Basic Description

Synonyms	851723-84-7\|OC000459\|timapiprant\|2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid\|OC-459\|OC-000459\|OC459\|ODC-9101\|OC000459(Timapiprant)\|1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-\|2-[5-fluoro-2-methyl-3-(quinol
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of DP 2 receptor
Note	卖完停产，不再备货
Product Description	OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.

Product Properties

ALogP	4.4

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

Discover Target: CX3CR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR35 Tchem G-protein coupled receptor 35 0 Activities

Discover Target: GPR35

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

Discover Target: FFAR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

Discover Target: S1PR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor 0 Activities

Discover Target: PTGDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR2 Tchem Prostaglandin D2 receptor 2 10 Activities

Discover Target: PTGDR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGIR Tclin Prostacyclin receptor 0 Activities

Discover Target: PTGIR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

Discover Target: C5AR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

Discover Target: ADRB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APLNR Tchem Apelin receptor 0 Activities

Discover Target: APLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

Discover Target: ADGRF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Discover Target: AKR1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

Discover Target: TBXA2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

Discover Target: GPR119

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid
INCHI	InChI=1S/C21H17FN2O2/c1-13-17(11-16-8-6-14-4-2-3-5-19(14)23-16)18-10-15(22)7-9-20(18)24(13)12-21(25)26/h2-10H,11-12H2,1H3,(H,25,26)
InChi Key	FATGTHLOZSXOBC-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)CC3=NC4=CC=CC=C4C=C3
Isomeric SMILES	CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)CC3=NC4=CC=CC=C4C=C3
Alternate CAS	851723-84-7,1422181-22-3
PubChem CID	11462174
MeSH Entry Terms	(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid;OC000459
Molecular Weight	348.37

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

1 results found

Lot Number	Certificate Type	Date	Item
H1503085	Certificate of Analysis	Mar 16, 2023	O127017

Chemical and Physical Properties

Solubility	DMSO

References

1. Pettipher R, Vinall SL, Xue L, Speight G, Townsend ER, Gazi L, Whelan CJ, Armer RE, Payton MA, Hunter MG. (2012) Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.. J Pharmacol Exp Ther, 340 (2): (473-82). [PMID:22106101]
2. Pettipher R, Hunter MG, Perkins CM, Collins LP, Lewis T, Baillet M, Steiner J, Bell J, Payton MA. (2014) Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459.. Allergy, 69 (9): (1223-32). [PMID:24866478]

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SKU	Size	Availability	Price
O127017-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$129.90
O127017-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$347.90
O127017-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$626.90

OC000459 - ≥98%, high purity , CAS No.851723-84-7, Antagonist of DP 2 receptor

Basic Description

Product Properties

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

GPR35 Tchem G-protein coupled receptor 35 0 Activities

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

PTGDR Tclin Prostaglandin D2 receptor 0 Activities

PTGDR2 Tchem Prostaglandin D2 receptor 2 10 Activities

PTGIR Tclin Prostacyclin receptor 0 Activities

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

BRPF1 Tchem Peregrin 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

APLNR Tchem Apelin receptor 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

AKR1B1 Tclin Aldose reductase 0 Activities

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

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