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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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O102402-1mg | 1mg | In stock | $80.90 | |
O102402-5mg | 5mg | In stock | $360.90 | |
O102402-25mg | 25mg | In stock | $1,440.90 |
Stimulates SERCA-ATP-dependent Ca2+pump activity
Synonyms | OCHRATOXIN A | 3R14S-Ochratoxin A | Ochratoxin A-BSA conjugate from Aspergillus ochraceus | CHEBI:7719 | OTA | Phenylalanine - ochratoxin A | Ochratoxin A(OTA) | Antibiotic 9663 | (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation. |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Ochratoxin A is a mycotoxin isolated from the Aspergillus ochraceus mold, a common fungal presence on moldy food. Ochratoxin A demonstrates nephrotoxicity and teratogenesis in animals, and shows inhibition of bacterial, yeast, and liver FARSL (phenylalanyl-tRNA synthetases) competitive with phenylalanine. As these activities are partially attenuated by phenylalanine, Ochratoxin A is suggested to produce its effects through interacting with proteins that recognize phenylalanine as a substrate, and has been demonstrated to inhibit PAH (phenylalanine hydroxylase). Derivatives of Ochratoxin A with other amino acid moieties substituted for the phenylalanine-mimic portion of the molecule demonstrate inhibition of the aminoacyl tRNA synthetases respective to those amino acids. Ochratoxin A is described to enhance lipid peroxidation and also present DNA single strand breaks, both suggesting oxidative damage as a partial mediator of Ochratoxin A cellular effects, and EPR spectroscopy with a spin trap agent identified the production of hydroxyl radicals by Ochratoxin A in the presence of NADPH. The nephrotoxic effects of Ochratoxin A are shown to be prevented by SOD (superoxide dismutase) and catalase, further indicating oxidative damage as the mediator of Ochratoxin A toxicity. Ochratoxin A is also demonstrated to increase ATP-dependent Ca2+ pump activity in renal cortex endoplasmic reticulum.Ochratoxin A is one of the mycotoxins typically produced by the species of Aspergillus genus. It is a commonly found secondary metabolite in cereals, coffee, grape must, wine, beer, etc. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488189794 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488189794 |
IUPAC Name | (2S)-2-[[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid |
INCHI | InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1 |
InChi Key | RWQKHEORZBHNRI-BMIGLBTASA-N |
Canonical SMILES | CC1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)NC(CC3=CC=CC=C3)C(=O)O)Cl |
Isomeric SMILES | C[C@@H]1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)Cl |
WGK Germany | 3 |
PubChem CID | 442530 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 403.81 |
Beilstein | 8169012 |
Wikipedia | Ochratoxin_A |
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CAS Registry No. | 303-47-9 |
PubChem CID | 442530 |
ChEMBL Ligand | CHEMBL589366 |
ChEBI | CHEBI:7719 |
RCSB PDB Ligand | 97U |
PubChem SID | 488189794 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2425588 | Certificate of Analysis | Sep 07, 2024 | O102402 |
I2425587 | Certificate of Analysis | Sep 07, 2024 | O102402 |
I2425586 | Certificate of Analysis | Sep 07, 2024 | O102402 |
G2415489 | Certificate of Analysis | Jul 05, 2024 | O102402 |
G2415488 | Certificate of Analysis | Jul 05, 2024 | O102402 |
C2428021 | Certificate of Analysis | Jun 09, 2023 | O102402 |
G2301241 | Certificate of Analysis | Jun 09, 2023 | O102402 |
G2301116 | Certificate of Analysis | Jun 09, 2023 | O102402 |
G2301115 | Certificate of Analysis | Jun 09, 2023 | O102402 |
E2309942 | Certificate of Analysis | Apr 25, 2023 | O102402 |
E2309983 | Certificate of Analysis | Apr 25, 2023 | O102402 |
E2309939 | Certificate of Analysis | Apr 25, 2023 | O102402 |
E2309938 | Certificate of Analysis | Apr 25, 2023 | O102402 |
E2309932 | Certificate of Analysis | Apr 25, 2023 | O102402 |
E23091009 | Certificate of Analysis | Apr 25, 2023 | O102402 |
E2112201 | Certificate of Analysis | May 19, 2021 | O102402 |
E2112200 | Certificate of Analysis | May 19, 2021 | O102402 |
E2112199 | Certificate of Analysis | May 19, 2021 | O102402 |
A2310419 | Certificate of Analysis | May 19, 2021 | O102402 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 20.19, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 40.38, Max Conc. mM: 100 |
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Sensitivity | Moisture sensitive;Light sensitive |
Flash Point(°C) | -11°C |
Pictogram(s) | GHS06, GHS08 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H300:Fatal if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Class | 6.1 |
Starting at $813.90
1. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486] [10.1039/D3AN01779F] |
2. Wenting Li, Yongqiang Shi, Xinai Zhang, Xuetao Hu, Xiaowei Huang, Nini Liang, Tingting Shen, Xiaobo Zou, Jiyong Shi. (2024) A DNA tetrahedral scaffolds-based electrochemical biosensor for simultaneous detection of AFB1 and OTA. FOOD CHEMISTRY, 442 (138312). [PMID:38219562] [10.1016/j.foodchem.2023.138312] |
3. Sen Wang, Hui Ren, Chen Fan, Qian Lin, Man Liu, Jun Tian. (2023) Ochratoxin A Induces Renal Cell Ferroptosis by Disrupting Iron Homeostasis and Increasing ROS. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38133486] [10.1021/acs.jafc.3c04495] |
4. Yanhua Wang, Xiaofang Wang, Yu-Cheng Zhu, Dou Wang, Lu Lv, Liezhong Chen, Yuanxiang Jin. (2024) Co-exposure ochratoxin A and triadimefon influenced the hepatic glucolipid metabolism and intestinal micro-environment in mice. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169339). [PMID:38103602] [10.1016/j.scitotenv.2023.169339] |
5. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma. (2023) 3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers. MICROCHEMICAL JOURNAL, (109598). [PMID:14728084] [10.1016/j.microc.2023.109598] |
6. Xin Liu, Chunli Yan, Chunxiao Chang, Fansong Meng, Wenjie Shen, Song Wang, Yi Zhang. (2023) Ochratoxin A promotes chronic enteritis and early colorectal cancer progression by targeting Rinck signaling. PHYTOMEDICINE, (155095). [PMID:37844381] [10.1016/j.phymed.2023.155095] |
7. Xianglin Liao, Yimin Liu, Liyu Qiu, Lu Cao, Xixiang Yang, Xiaogang Hu. (2023) A quantum dot aptamer fluorescent sensor based on magnetic graphene oxide for the detection of zearalenone. Analytical Methods, 15 (37): (4946-4953). [PMID:37721206] [10.1039/D3AY01260C] |
8. Yumeng Liao, Nan Zhang, Danni Chai, Boshi Liu, Jingrong Li, Yuting Fang, Di Zhang, Rui Liu, Zheng Li. (2023) Rational design of ratiometric fluorescent aptasensor for patulin in traditional Chinese medicine through the studies of interaction mechanism between DNA aptamer and target molecule. ANALYST, (3): [PMID:37725068] [10.1039/D3AN00923H] |
9. Ziyang He, Jinxin Zhang, Mei Liu, Yonghong Meng. (2024) Polyvalent aptamer scaffold coordinating light-responsive oxidase-like nanozyme for sensitive detection of zearalenone. FOOD CHEMISTRY, 431 (136908). [PMID:37573743] [10.1016/j.foodchem.2023.136908] |
10. Yijian Zhao, Tianyue Liu, Jinghui Gao, Qiaojuan Zhang, Mengyu Liao, He Cheng, Jingsheng Tian, Zhiyi Yao. (2023) Nanoassemblies Based on a Cationic Perylene Diimide Derivative and Sodium Dodecyl Sulfate: A Simple Fluorescent Platform for Efficient Analysis of Aflatoxin B1. ANALYTICAL CHEMISTRY, 95 (21): (8250–8257). [PMID:37186575] [10.1021/acs.analchem.3c00170] |
11. Jiawei Zhang, Jie Zhao, Xinxin Shi, Zhiwei Sun, Jinmao You. (2023) Development of a method for the quantification of six mycotoxins in cereal samples using isotope-coded derivatization combined with ultra-high-performance liquid chromatography–tandem mass spectrometry. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 120 (105347). [PMID:] [10.1016/j.jfca.2023.105347] |
12. Sai Zhang, Yahui Wang, Qinglin Sheng, Tianli Yue. (2023) Electrochemical Aptasensor Based on ZnO-Au Nanocomposites for the Determination of Ochratoxin A in Wine and Beer. Processes, 11 (3): (864). [PMID:] [10.3390/pr11030864] |
13. Qingxin Zhang, Manru Zhang, Zhiqiang Guo, Jingjing Li, Zhixue Zhu, Yu Wang, Su Liu, Jiadong Huang, Jinghua Yu. (2023) DNA tetrahedron-besieged primer and DNAzyme-activated programmatic RCA for low-background electrochemical detection of ochratoxin A. ANALYTICA CHIMICA ACTA, 1242 (340782). [PMID:36657887] [10.1016/j.aca.2023.340782] |
14. Jie Zhang, Yuheng Lu, Wei Gao, Peng Yang, Nansheng Cheng, Yanwen Jin, Junbo Chen. (2023) Structure-switching locked hairpin triggered rolling circle amplification for ochratoxin A (OTA) detection by ICP-MS. MICROCHEMICAL JOURNAL, 186 (108365). [PMID:] [10.1016/j.microc.2022.108365] |
15. Zhang Hong, Wang Yuli, Lin Yingtong, Chu Wenjuan, Luo Zhen, Zhao Mingqin, Hu Jiandong, Miao Xiangmin, He Fan. (2023) A catalytic hairpin assembly–based Förster resonance energy transfer sensor for ratiometric detection of ochratoxin A in food samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (5): (867-874). [PMID:36564526] [10.1007/s00216-022-04479-5] |
16. Mengran Wang, Linqing Shan, Xianglong Kong, Ruiyan Pan, Haiwei Wang, Jin Zhou, Jingjing Ming. (2023) A label-free fluorescence strategy for analysis of aflatoxin M1 by self-protected DNAzyme and aptamer recognition triggered DNA walker cascade amplification. MICROCHEMICAL JOURNAL, 186 (108356). [PMID:] [10.1016/j.microc.2022.108356] |
17. Anping Wang, Jianing Liu, Jinlan Yang, Li Yang. (2023) Aptamer affinity-based microextraction in-line coupled to capillary electrophoresis mass spectrometry using a porous layer/nanoparticle -modified open tubular column. ANALYTICA CHIMICA ACTA, 1239 (340750). [PMID:36628776] [10.1016/j.aca.2022.340750] |
18. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei. (2023) ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins. MICROCHIMICA ACTA, 190 (1): (1-10). [PMID:36471087] [10.1007/s00604-022-05593-y] |
19. Dongyan Li, Huaiyue Xia, Yingying Sun, Wenjie Liu, Wen Liu, Jianna Yu, Guoxing Jing, Jian Zhang, Wenshan Li. (2023) Colorimetric aptasensor for the sensitive detection of ochratoxin A based on a triple cascade amplification strategy. ANALYTICA CHIMICA ACTA, 1237 (340616). [PMID:36442942] [10.1016/j.aca.2022.340616] |
20. Yongmei Jia, Qiuxia Lai, Zhiguo Li, Guohua Zhou, Peilian Liu, Xunbo Lu, Mingyue Xue, Yong Cheng. (2022) Construction of AIEgens and graphene oxide based aptasensor with two-fluorescent signals for determination of Aflatoxin B1 in food Samples. GIANT, 12 (100132). [PMID:] [10.1016/j.giant.2022.100132] |
21. Hao Wang, Lu Chen, Min Li, Yongxin She, Chao Zhu, Mengmeng Yan. (2022) An Alkyne-Mediated SERS Aptasensor for Anti-Interference Ochratoxin A Detection in Real Samples. Foods, 11 (21): (3407). [PMID:36360020] [10.3390/foods11213407] |
22. Jian Guo, Zhiping He, Chao Ma, Wanting Li, Jiaoyu Wang, Fucheng Lin, Xingquan Liu, Ling Li. (2023) Evaluation of cold plasma for decontamination of molds and mycotoxins in rice grain. FOOD CHEMISTRY, 402 (134159). [PMID:36137380] [10.1016/j.foodchem.2022.134159] |
23. Kemin Shen, Xiaoqin Hu, Linlin Sun, Chun Han, Jianzhou Yang. (2022) Development of a Lateral Flow Strip with a Positive Readout for the On-Site Detection of Aflatoxin B1. MOLECULES, 27 (15): (4949). [PMID:35956902] [10.3390/molecules27154949] |
24. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [PMID:] [10.1080/09540105.2022.2080188] |
25. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li. (2022) A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles. FOOD CHEMISTRY, 389 (133078). [PMID:35490524] [10.1016/j.foodchem.2022.133078] |
26. Guohua Xu, Jiajing Zhao, Hao Yu, Chen Wang, Yangyu Huang, Qiang Zhao, Xin Zhou, Conggang Li, Maili Liu. (2022) Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer. Journal of the American Chemical Society, 144 (17): (7731–7740). [PMID:35442665] [10.1021/jacs.2c00478] |
27. Wang Yulin, Li Yangyang, Luo Yiling, Zhou Kailian, Qiu Xiuzhen, Guo Huishi. (2022) A novel molecularly imprinted polymer material for the recognition of ochratoxin A. JOURNAL OF POLYMER RESEARCH, 29 (5): (1-11). [PMID:] [10.1007/s10965-022-03005-6] |
28. Min Li, Hao Wang, Xiaodi Yu, Xindi Jia, Chao Zhu, Jiahui Liu, Fan Zhang, Zilei Chen, Mengmeng Yan, Qinzheng Yang. (2022) A sensitive and simple competitive nanozyme-linked apta-sorbent assay for the dual-mode detection of ochratoxin A. ANALYST, 147 (10): (2215-2222). [PMID:35467672] [10.1039/D1AN02335G] |
29. Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia, Xiaoli Wang, Nandi Zhou. (2022) A fluorescence and surface-enhanced Raman scattering dual-mode aptasensor for rapid and sensitive detection of ochratoxin A. BIOSENSORS & BIOELECTRONICS, 207 (114164). [PMID:35320745] [10.1016/j.bios.2022.114164] |
30. Lu Yang, Jin Wang, Huan Lv, Xue-Meng Ji, Jing-Min Liu, Shuo Wang. (2022) Hollow-Structured Microporous Organic Networks Adsorbents Enabled Specific and Sensitive Identification and Determination of Aflatoxins. Toxins, 14 (2): (137). [PMID:35202164] [10.3390/toxins14020137] |
31. Fuxiang Wang, Zuopeng Li, Hongping Jia, Runhua Lu, Sanbing Zhang, Canping Pan, Zhiqiang Zhang. (2022) An ultralow concentration of Al-MOFs for turn-on fluorescence detection of aflatoxin B1 in tea samples. FOOD CHEMISTRY, 383 (132389). [PMID:35180600] [10.1016/j.foodchem.2022.132389] |
32. Wenting Li, Xinai Zhang, Xuetao Hu, Yongqiang Shi, Nini Liang, Xiaowei Huang, Xin Wang, Tingting Shen, Xiaobo Zou, Jiyong Shi. (2022) Simple Design Concept for Dual-Channel Detection of Ochratoxin A Based on Bifunctional Metal–Organic Framework. ACS Applied Materials & Interfaces, 14 (4): (5615–5623). [PMID:35050582] [10.1021/acsami.1c22809] |
33. Zhiwen Huang, María Luisa Cerón, Kehuai Feng, Dan Wang, María Belén Camarada, Xiaoning Liao. (2022) Anchoring black phosphorus quantum dots over carboxylated multiwalled carbon nanotubes: A stable 0D/1D nanohybrid with high sensing performance to Ochratoxin a. APPLIED SURFACE SCIENCE, 583 (152429). [PMID:] [10.1016/j.apsusc.2022.152429] |
34. Qian-Wen Zheng, Xu-Fen Ding, Hui-Jun Cao, Qian-Zhi Ni, Bing Zhu, Ning Ma, Feng-Kun Zhang, Yi-Kang Wang, Sheng Xu, Tian-Wei Chen, Ji Xia, Xiao-Song Qiu, Dian-Zhen Yu, Dong Xie, Jing-Jing Li. (2021) Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis. Toxins, 13 (11): (802). [PMID:34822586] [10.3390/toxins13110802] |
35. Zhang Xue, Liao Xiaoning, Wu Yongfa, Xiong Wanming, Du Juan, Tu Zhui, Yang Wuying, Wang Dan. (2022) A sensitive electrochemical immunosensing interface for label-free detection of aflatoxin B1 by attachment of nanobody to MWCNTs-COOH@black phosphorene. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (2): (1129-1139). [PMID:34719746] [10.1007/s00216-021-03738-1] |
36. Chengxi Zhu, Dong Liu, Yuye Li, Ting Chen, Tianyan You. (2022) Label-free ratiometric homogeneous electrochemical aptasensor based on hybridization chain reaction for facile and rapid detection of aflatoxin B1 in cereal crops. FOOD CHEMISTRY, 373 (131443). [PMID:34742048] [10.1016/j.foodchem.2021.131443] |
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