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TKL:Tyrosine kinase-like
OD 36 hydrochloride - ≥98%(HPLC), high purity , CAS No.1638644-62-8, Inhibitor of receptor interacting serine/threonine kinase 2

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OD 36 hydrochloride - ≥98%(HPLC), high purity , CAS No.1638644-62-8, Inhibitor of receptor interacting serine/threonine kinase 2

Moligand™

≥98%(HPLC)

CAS#: 1638644-62-8
Formula: C₁₆H₁₅ClN₄O₂•HCl
Molecular Weight: 367.23
PubChem CID: 135567262

Item Number

O287326

Grouped product items
SKU	Size	Availability	Price	Qty
O287326-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$194.90

Potent RIP2 kinase inhibitor

View related series

Apoptosis receptor interacting serine/threonine kinase 2 Inhibitor RIP kinase TGF-beta/Smad TGF-β Receptor

Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50= 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mo
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of receptor interacting serine/threonine kinase 2

Associated Targets(Human)

GAK Tchem Cyclin-G-associated kinase (2 Activities)

Discover Target: GAK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 (1 Activities)

Discover Target: RIPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GAK Tchem Serine/threonine-protein kinase GAK (1150 Activities)

Discover Target: GAK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-chloro-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene
INCHI	InChI=1S/C16H15ClN4O2/c17-12-7-11-8-13(9-12)23-6-5-22-4-2-18-15-1-3-21-16(20-15)14(11)10-19-21/h1,3,7-10H,2,4-6H2,(H,18,20)
InChi Key	KTSDBMVHAKWDRK-UHFFFAOYSA-N
Canonical SMILES	C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl
Isomeric SMILES	C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl
PubChem CID	135567262
Molecular Weight	367.23

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 36.72, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 1.84, Max Conc. mM: 5

References

1. Tigno-Aranjuez JT, Benderitter P, Rombouts F, Deroose F, Bai X, Mattioli B, Cominelli F, Pizarro TT, Hoflack J, Abbott DW. (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.. J Biol Chem, 289 (43): (29651-64). [PMID:25213858] [10.1021/op500134e]

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