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TKL:Tyrosine kinase-like
OD 36 hydrochloride - ≥98%(HPLC), high purity , CAS No.1638644-62-8, Inhibitor of receptor interacting serine/threonine kinase 2

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OD 36 hydrochloride - ≥98%(HPLC), high purity , CAS No.1638644-62-8, Inhibitor of receptor interacting serine/threonine kinase 2

Moligand™
≥98%(HPLC)

CAS#: 1638644-62-8
Formula: C₁₆H₁₅ClN₄O₂•HCl
Molecular Weight: 367.23
PubChem CID: 135567262

Item Number

O287326

Grouped product items
SKU	Size	Availability	Price	Qty
O287326-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$194.90

Potent RIP2 kinase inhibitor

View related series

receptor interacting serine/threonine kinase 2 Inhibitor

Basic Description

Synonyms	6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
Specifications & Purity	≥98%(HPLC)
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of receptor interacting serine/threonine kinase 2

Associated Targets

GAK Tchem Cyclin-G-associated kinase 0 Activities

Discover Target: GAK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 0 Activities

Discover Target: RIPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-chloro-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene
INCHI	InChI=1S/C16H15ClN4O2/c17-12-7-11-8-13(9-12)23-6-5-22-4-2-18-15-1-3-21-16(20-15)14(11)10-19-21/h1,3,7-10H,2,4-6H2,(H,18,20)
InChi Key	KTSDBMVHAKWDRK-UHFFFAOYSA-N
Canonical SMILES	C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl
Isomeric SMILES	C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl
PubChem CID	135567262
Molecular Weight	367.23

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 36.72, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 1.84, Max Conc. mM: 5

References

1. Tigno-Aranjuez JT, Benderitter P, Rombouts F, Deroose F, Bai X, Mattioli B, Cominelli F, Pizarro TT, Hoflack J, Abbott DW. (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.. J Biol Chem, 289 (43): (29651-64). [PMID:25213858]

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