Odanacatib is an inhibitor of cathepsin K, an enzyme involved in bone resorption.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of cathepsin K;Inhibitor of cathepsin S;Inhibitor of cathepsin Z
Product Description
A cathepsin K inhibitor. Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
1.Brixen K, Chapurlat R, Cheung AM, Keaveny TM, Fuerst T, Engelke K, Recker R, Dardzinski B, Verbruggen N, Ather S et al.. (2013) Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib: a randomized trial.. J Clin Endocrinol Metab, 98 (2):(571-80). [PMID:23337728]
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