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OF 1 - 10mM in DMSO, high purity , CAS No.919973-83-4
Selective BRPF1B and BRPF2 inhibitor
Basic Description Synonyms OF-1|919973-83-4|SGC OF-1|OF 1|4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide|4-Bromanyl-~{n}-(6-Methoxy-1,3-Dimethyl-2-Oxidanylidene-Benzimidazol-5-Yl)-2-Methyl-Benzenesulfonamide|CHEMBL3770173|4- Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Selective BRPF1B and BRPF2 bromodomain inhibitor (Kdvalues are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5μM in a BRPF2 FRAP assay. Inhibits RANKL-induced differentiation of pri Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Names and Identifiers IUPAC Name 4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide INCHI InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3 InChi Key YUNQZQREIHWDQT-UHFFFAOYSA-N Canonical SMILES CC1=C(C=CC(=C1)Br)S(=O)(=O)NC2=CC3=C(C=C2OC)N(C(=O)N3C)C Isomeric SMILES CC1=C(C=CC(=C1)Br)S(=O)(=O)NC2=CC3=C(C=C2OC)N(C(=O)N3C)C Alternate CAS 919973-83-4 PubChem CID 35397514 Molecular Weight 440.31
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H301: Toxic if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P337+P317: If eye irritation persists: Get medical help.
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