Skip to the beginning of the images gallery

Ofloxacin - 98%, high purity , Bacterial DNA gyrase inhibitor, CAS No.82419-36-1, Bacterial DNA gyrase inhibitor

Moligand™
≥98%

CAS#: 82419-36-1
Formula: C₁₈H₂₀FN₃O₄
Molecular Weight: 361.37
MDL number: MFCD00226105
PubChem CID: 4583

Item Number

O102014

Grouped product items
SKU	Size	Availability	Price
O102014-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$122.90
O102014-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$197.90
O102014-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$891.90
O102014-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,207.90
O102014-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$14,434.90

View related series

Oxazines Six-Membered Heterocyclic Compounds

Basic Description

Synonyms	ofloxacin\|82419-36-1\|Floxin\|Ofloxacine\|Tarivid\|Oxaldin\|Ocuflox\|Oflocet\|Visiren\|OFLX\|Hoe-280\|Ofloxacino\|Ofloxacinum\|DL-8280\|Ofloxacina\|Exocin\|Floxin otic\|Ofloxacin Otic\|HOE 280\|Ofloxacinum [Latin]\|FLOXIN IN DEXTROSE 5%\|ORF 18489\|CCRIS 5233\|CHEBI:7731\|9-flu
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Bacterial DNA gyrase inhibitor
Product Description	Product Introduction Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery

Product Properties

ALogP	-0.4

Associated Targets

TAS2R9 Tchem Taste receptor type 2 member 9 0 Activities

Discover Target: TAS2R9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
INCHI	InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChi Key	GSDSWSVVBLHKDQ-UHFFFAOYSA-N
Canonical SMILES	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Isomeric SMILES	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
PubChem CID	4583
Molecular Weight	361.37

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot Number	Certificate Type	Date	Item
D2412338	Certificate of Analysis	Mar 13, 2024	O102014
D2412336	Certificate of Analysis	Mar 13, 2024	O102014
D2412340	Certificate of Analysis	Mar 13, 2024	O102014
D23181258	Certificate of Analysis	Feb 14, 2023	O102014
D23181334	Certificate of Analysis	Feb 14, 2023	O102014
D23181337	Certificate of Analysis	Feb 14, 2023	O102014
D23181339	Certificate of Analysis	Feb 14, 2023	O102014
C2204628	Certificate of Analysis	Dec 20, 2021	O102014
C2204634	Certificate of Analysis	Dec 20, 2021	O102014
C2204637	Certificate of Analysis	Dec 20, 2021	O102014
C2204638	Certificate of Analysis	Dec 20, 2021	O102014
C2413058	Certificate of Analysis	Aug 14, 2021	O102014
E2420006	Certificate of Analysis	Aug 14, 2021	O102014

Chemical and Physical Properties

Solubility	Soluble in acetic acid or water. Slightly soluble in methanol
Sensitivity	Light and moisture sensitive
Melt Point(°C)	263-269℃

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H341:Suspected of causing genetic defects H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
Merck Index	6771

References

1. M Baki,I Bodrogi,J Horti,L Géczi. (1994-12-18) [Review of drugs used in the neutropenic period following cytostatic therapy and comparative study of doxycycline and ofloxacin in the treatment of patients with testicular cancer].. Orvosi hetilap, 135 ((51)): (2815-2819). [PMID:7838516]
2. V P Iakovlev. (1996-01-01) [Pharmacokinetic properties of ofloxacin (review of the literature].. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 41 ((9)): (24-32). [PMID:9005781]
3. S V Onrust,H M Lamb,J A Balfour. (1998-11-26) Ofloxacin. A reappraisal of its use in the management of genitourinary tract infections.. Drugs, 56 ((5)): (895-928). [PMID:9829160]
4. Talen K H Wai,Michael C F Tong. (2003-04-12) A benefit-risk assessment of ofloxacin otic solution in ear infection.. Drug safety, 26 ((6)): (405-420). [PMID:12688832]
5. Motoi Tobita,Tetsuo Nishikawa,Renpei Nagashima. (2005-05-25) A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.. Bioorganic & medicinal chemistry letters, 15 ((11)): (2886-2890). [PMID:15911273]
6. Céline Vidaillac,Jean Guillon,Corinne Arpin,Isabelle Forfar-Bares,Boubakar B Ba,Jean Grellet,Stéphane Moreau,Daniel-Henri Caignard,Christian Jarry,Claudine Quentin. (2006-11-15) Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus.. Antimicrobial agents and chemotherapy, 51 ((3)): (831-838). [PMID:17101679]
7. Naz M Aghatabay,A Neshat,T Karabiyik,M Somer,D Haciu,B Dülger. (2006-12-27) Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand.. European journal of medicinal chemistry, 42 ((2)): (205-213). [PMID:17189664]
8. Stéphanie Matrat,Stéphanie Petrella,Emmanuelle Cambau,Wladimir Sougakoff,Vincent Jarlier,Alexandra Aubry. (2007-02-28) Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones.. Antimicrobial agents and chemotherapy, 51 ((5)): (1643-1648). [PMID:17325221]
9. Nuno Mendonça,Joana Leitão,Vera Manageiro,Eugénia Ferreira,Manuela Caniça. (2007-03-21) Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal.. Antimicrobial agents and chemotherapy, 51 ((6)): (1946-1955). [PMID:17371815]
10. S Güniz Küçükgüzel,Ilkay Küçükgüzel,Esra Tatar,Sevim Rollas,Fikrettin Sahin,Medine Güllüce,Erik De Clercq,Levent Kabasakal. (2007-04-10) Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.. European journal of medicinal chemistry, 42 ((7)): (893-901). [PMID:17418454]
11. Stéphanie Arsène,Roland Leclercq. (2007-07-11) Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones.. Antimicrobial agents and chemotherapy, 51 ((9)): (3254-3258). [PMID:17620379]
12. Ozlem Temiz-Arpaci,Ilkay Yildiz,Semiha Ozkan,Fatma Kaynak,Esin Aki-Sener,Ismail Yalçin. (2007-11-21) Synthesis and biological activity of some new benzoxazoles.. European journal of medicinal chemistry, 43 ((7)): (1423-1431). [PMID:18023934]
13. Masato Higashide,Makoto Kuroda,Carlos Takashi Neves Omura,Miyuki Kumano,Saburo Ohkawa,Sadahiro Ichimura,Toshiko Ohta. (2008-03-26) Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.. Antimicrobial agents and chemotherapy, 52 ((6)): (2061-2068). [PMID:18362191]
14. Lei Jia,Hongmao Sun. (2008-05-02) Support vector machines classification of hERG liabilities based on atom types.. Bioorganic & medicinal chemistry, 16 ((11)): (6252-6260). [PMID:18448342]
15. Jenny M Pedersen,Pär Matsson,Christel A S Bergström,Ulf Norinder,Janet Hoogstraate,Per Artursson. (2008-05-07) Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).. Journal of medicinal chemistry, 51 ((11)): (3275-3287). [PMID:18457386]
16. Tugba Ertan,Ilkay Yildiz,Betul Tekiner-Gulbas,Kayhan Bolelli,Ozlem Temiz-Arpaci,Semiha Ozkan,Fatma Kaynak,Ismail Yalcin,Esin Aki. (2008-06-06) Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.. European journal of medicinal chemistry, 44 ((2)): (501-510). [PMID:18524419]
17. Hua-Dong Chen,Sheng-Ping Yang,Yan Wu,Lei Dong,Jian-Min Yue. (2009-03-12) Terpenoids from Toona ciliata.. Journal of natural products, 72 ((4)): (685-689). [PMID:19275174]
18. Ioanna Spyridaki,Anna Psaroulaki,Iosif Vranakis,Yannis Tselentis,Achilleas Gikas. (2009-04-01) Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics.. Antimicrobial agents and chemotherapy, 53 ((6)): (2690-2692). [PMID:19332671]
19. R J Suchland,K M Sandoz,B M Jeffrey,W E Stamm,D D Rockey. (2009-08-19) Horizontal transfer of tetracycline resistance among Chlamydia spp. in vitro.. Antimicrobial agents and chemotherapy, 53 ((11)): (4604-4611). [PMID:19687238]
20. Hideaki Maseda,Yumiko Hashida,Rumi Konaka,Akihiro Shirai,Hiroki Kourai. (2009-09-16) Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.. Antimicrobial agents and chemotherapy, 53 ((12)): (5230-5235). [PMID:19752278]
21. Delphine Girlich,Laurent Poirel,Patrice Nordmann. (2009-11-04) First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate.. Antimicrobial agents and chemotherapy, 54 ((1)): (578-579). [PMID:19884362]
22. Gianpaolo Chiriano,Angela De Simone,Francesca Mancini,Daniel I Perez,Andrea Cavalli,Maria Laura Bolognesi,Giuseppe Legname,Ana Martinez,Vincenza Andrisano,Paolo Carloni,Marinella Roberti. (2012-01-03) A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.. European journal of medicinal chemistry, 48 (206-213). [PMID:22209418]
23. Célia Lloret-Linares,Stéphane Mouly,Dan-Tranh Hoang-Nguyen,John Evans,Laurent Raskine,Amanda Lopes,Emmanuelle Cambau,Jean-François Bergmann,Pierre Sellier. (2013-01-18) Inadequate therapeutic response to a recommended antituberculosis fixed-dose combination regimen in an overweight patient with Mycobacterium bovis infection.. The Annals of pharmacotherapy, 47 ((1)): (e4-e4). [PMID:23324515]
24. Maria Da Graça Souza Cunha,Marcos Virmond,Antonio Pedro Schettini,Rossilene Conceição Cruz,Somei Ura,Cassio Ghuidella,Francisco Dos Reis Viana,João Carlos Regazzi Avelleira,Antônio A Augusto Campos,Brasil Filho. (2013-01-30) OFLOXACIN multicentre trial in MB leprosy FUAM-Manaus and ILSL-Bauru, Brazil.. Leprosy review, 83 ((3)): (261-268). [PMID:23356027]
25. . (2013-02-05) [The outcome of a survey on the use of levofloxacin for the treatment of tuberculosis].. Kekkaku : [Tuberculosis], 87 ((9)): (599-608). [PMID:23378997]
26. B Vagamon,K-C Ahogo,B-R Aka,A Diabaté,Y-I Kouassi,S-H Kourouma,C Traoré,I Gue,P Yoboue,J-M Kanga,A Taieb. (2013-02-12) [Bifocal Buruli ulcer: multiple cephalic lesions after initiation of medical treatment].. Annales de dermatologie et de venereologie, 140 ((2)): (125-128). [PMID:23395495]
27. M Aboubakr. (2013-02-13) Pharmacokinetics of levofloxacin in Japanese quails (Coturnix japonica) following intravenous and oral administration.. British poultry science, 53 ((6)): (784-789). [PMID:23398423]
28. Koji Toriyama,Tomoyuki Inoue,Takashi Suzuki,Ritsuko Higashiura,Naoyuki Maeda,Yuichi Ohashi. (2013-02-15) Spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops.. Cornea, 32 ((6)): (839-841). [PMID:23407319]
29. Dennis A K Rice,Koné Kaniga,Michael Lee,Rebecca Redman. (2013-02-16) Activity of doripenem versus comparators in subjects with baseline bacteraemia in six pooled phase 3 clinical trials.. International journal of antimicrobial agents, 41 ((4)): (388-392). [PMID:23410792]
30. Tomoshige Matsumoto,Hideo Ogata,Emiko Toyota,Katsuhiro Suzuki,Takefumi Saito,Akira Fujita,Toshinori Suetake,Kinuyo Chikamatsu,Kazue Mizuno,Satoshi Mitarai. (2013-05-16) [Clinical evaluation of a line probe assay kit for the identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis].. Kekkaku : [Tuberculosis], 88 ((3)): (291-296). [PMID:23672169]
31. Sergio Fusco,Francesca Reitano,Nicola Gambadoro,Marcello Previti,Giuseppina Russo,Giorgio Basile,Domenico Cucinotta. (2013-09-14) Severe hypoglycemia associated with levofloxacin in a healthy older woman.. Journal of the American Geriatrics Society, 61 ((9)): (1637-1638). [PMID:24028371]
32. Nethaji Ramalingam,Gopal Natesan,Brahatheeswaran Dhandayuthapani,Perumal Perumal,Jayakar Balasundaram,Subramanian Natesan. (2013-11-06) Design and characterization of ofloxacin niosomes.. Pakistan journal of pharmaceutical sciences, 26 ((6)): (1089-1096). [PMID:24191311]
33. Züleyha Yalniz-Akkaya,Gulcin Guler Simsek,Guner Ozkan Uney,Ayse Burcu,Firdevs Ornek. (2014-01-15) Effect of cauterization on the subconjunctival fibrovascular reaction in rabbit eyes.. Seminars in ophthalmology, 30 ((3)): (202-205). [PMID:24409945]
34. Fu-Tao Zhang,Yi Ding,Zahir Shah,Dan Xing,Yuan Gao,Dong Ming Liu,Ming-Xing Ding. (2014-03-04) TNF/TNFR₁ pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes.. Toxicology and applied pharmacology, 276 ((2)): (121-128). [PMID:24582689]
35. Yasuhiro Horita,Norio Doi. (2014-03-26) Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.. Antimicrobial agents and chemotherapy, 58 ((6)): (3168-3176). [PMID:24663015]
36. Deivasigamani Ranjith Kumar,Devaraj Manoj,Jayadevan Santhanalakshmi. (2014-04-25) Optimization of oleylamine-Fe3O4/MWCNTs nanocomposite modified GC electrode for electrochemical determination of ofloxacin.. Journal of nanoscience and nanotechnology, 14 ((7)): (5059-5069). [PMID:24757981]
37. Minjie Chen,Yishan Qian,Jinhui Dai,Renyuan Chu. (2014-05-09) The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs.. PloS one, 9 ((5)): (e96952-e96952). [PMID:24810957]
38. Guan Liu,Gui-Rong Wang,Xia Yu,Qian Liang,Jing Mu,Yuan-Yuan Shang,Ying Ling,Hai-Qing Zhang,Su-Hua Zheng,Hai-Rong Huang. (2014-05-27) Bacteriological characterization of a Mycobacterium parascrofulaceum strain isolated from a Chinese pneumonia patient.. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 25 (82-87). [PMID:24858903]
39. Tuba Celik,Dilek Yuksel,Mustafa Kosker,Remzi Kasim,Saban Simsek. (2014-05-30) Vascularization of coralline versus synthetic hydroxyapatite orbital implants assessed by gadolinium enhanced magnetic resonance imaging.. Current eye research, 40 ((3)): (346-353). [PMID:24871378]
40. Hua Gao,Peng Song,Jose J Echegaray,Yanni Jia,Suxia Li,Man Du,Victor L Perez,Weiyun Shi. (2014-08-12) Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis.. Journal of ophthalmology, 2014 (209759-209759). [PMID:25105019]
41. Do-Won Jeong,Seulhwa Han,Jong-Hoon Lee. (2014-08-12) Safety and technological characterization of Staphylococcus equorum isolates from jeotgal, a Korean high-salt-fermented seafood, for starter development.. International journal of food microbiology, 188 (108-115). [PMID:25106039]
42. Imen Mokdad-Bzeouich,Nadia Mustapha,Fadwa Chaabane,Zied Ghedira,Kamel Ghedira,Mohamed Ghoul,Latifa Chebil,Leila Chekir-Ghedira. (2014-09-25) Oligomerization of esculin improves its antibacterial activity and modulates antibiotic resistance.. The Journal of antibiotics, 68 ((3)): (148-152). [PMID:25248728]
43. Siriporn Kongsoi,Kazumasa Yokoyama,Apinun Suprasert,Fuangfa Utrarachkij,Chie Nakajima,Orasa Suthienkul,Yasuhiko Suzuki. (2014-11-11) Characterization of Salmonella Typhimurium DNA gyrase as a target of quinolones.. Drug testing and analysis, 7 ((8)): (714-720). [PMID:25381884]
44. Yesheng Xu,Yabo Yang. (2014-11-15) Small-incision lenticule extraction for myopia: results of a 12-month prospective study.. Optometry and vision science : official publication of the American Academy of Optometry, 92 ((1)): (123-131). [PMID:25397926]
45. Jie Feng,Paul G Auwaerter,Ying Zhang. (2015-03-26) Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline.. PloS one, 10 ((3)): (e0117207-e0117207). [PMID:25806811]
46. N Dorival-García,C Labajo-Recio,A Zafra-Gómez,B Juárez-Jiménez,J L Vílchez. (2015-04-13) Improved sample treatment for the determination of 17 strong sorbed quinolone antibiotics from compost by ultra high performance liquid chromatography tandem mass spectrometry.. Talanta, 138 (247-257). [PMID:25863398]
47. George D Kymionis,Dimitrios A Liakopoulos,Michael A Grentzelos,Konstantinos I Tsoulnaras,Efstathios T Detorakis,Béatrice Cochener,Miltiadis K Tsilimbaris. (2015-06-10) Effect of the Regenerative Agent Poly(Carboxymethylglucose Sulfate) on Corneal Wound Healing After Corneal Cross-Linking for Keratoconus.. Cornea, 34 ((8)): (928-931). [PMID:26057328]
48. Yoshihiko Shimokawa,Noriaki Yoda,Satoshi Kondo,Yoshiya Yamamura,Yoshiharu Takiguchi,Ken Umehara. (2015-06-23) Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.. Biological & pharmaceutical bulletin, 38 ((9)): (1425-1429). [PMID:26094899]
49. Qiang Xue,Yanjie Qi,Fei Liu. (2015-06-25) Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.. Environmental science and pollution research international, 22 ((21)): (16857-16867). [PMID:26104902]
50. Melisa Guven,Reto Brem,Peter Macpherson,Matthew Peacock,Peter Karran. (2015-07-03) Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells.. The Journal of investigative dermatology, 135 ((11)): (2834-2841). [PMID:26134950]
51. Yi Yao,Cui Ling Xu,Jing Hong Shi,Yun Zhu,Yun Fei Li,Tian Bai,Fang Cai Li,Tao Cai,Fan Yuan,Tao Chen,Hao Yang,Wen Chao Li,Heng Jiao Zhang,Hong Zhang,Yue Long Shu. (2015-08-08) Phylogenetic and Molecular Analysis of an H7N7 Avian Influenza Virus Isolated in East Dongting Lake in 2012.. Biomedical and environmental sciences : BES, 28 ((7)): (518-526). [PMID:26248736]
52. Dan Z Reinstein,Marine Gobbe,Louis Gobbe,Timothy J Archer,Glenn I Carp. (2015-09-10) Optical Zone Centration Accuracy Using Corneal Fixation-based SMILE Compared to Eye Tracker-based Femtosecond Laser-assisted LASIK for Myopia.. Journal of refractive surgery (Thorofare, N.J. : 1995), 31 ((9)): (586-592). [PMID:26352563]
53. Paulo C F Lima Gomes,Inês N Tomita,Álvaro J Santos-Neto,Marcelo Zaiat. (2015-10-09) Rapid determination of 12 antibiotics and caffeine in sewage and bioreactor effluent by online column-switching liquid chromatography/tandem mass spectrometry.. Analytical and bioanalytical chemistry, 407 ((29)): (8787-8801). [PMID:26446896]
54. K L Simpson,A Markham. (1999-09-24) Ofloxacin otic solution: a review of its use in the management of ear infections.. Drugs, 58 ((3)): (509-531). [PMID:10493278]
55. J O Klein. (2001-02-15) In vitro and in vivo antimicrobial activity of topical ofloxacin and other ototopical agents.. The Pediatric infectious disease journal, 20 ((1)): (102-103). [PMID:11176586]
56. Philippe Villain-Guillot,Maxime Gualtieri,Lionel Bastide,Françoise Roquet,Jean Martinez,Muriel Amblard,Martine Pugniere,Jean-Paul Leonetti. (2007-08-02) Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms.. Journal of medicinal chemistry, 50 ((17)): (4195-4204). [PMID:17665895]
57. Mohd Amir,Harish Kumar,S A Javed. (2007-11-21) Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.. European journal of medicinal chemistry, 43 ((10)): (2056-2066). [PMID:18023930]
58. Naz Mohammed Aghatabay,Yaghub Mahmiani,Hüseyin Cevik,Başaran Dulger. (2008-04-18) Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds.. European journal of medicinal chemistry, 44 ((1)): (365-372). [PMID:18417256]
59. Sonja Hansen,Kim Lewis,Marin Vulić. (2008-06-04) Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli.. Antimicrobial agents and chemotherapy, 52 ((8)): (2718-2726). [PMID:18519731]
60. Kin Y Tam,Alex Avdeef,Oksana Tsinman,Na Sun. (2009-12-02) The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.. Journal of medicinal chemistry, 53 ((1)): (392-401). [PMID:19947605]
61. Mirva Lehtopolku,Ulla-Maija Nakari,Pirkko Kotilainen,Pentti Huovinen,Anja Siitonen,Antti J Hakanen. (2009-12-30) Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents.. Antimicrobial agents and chemotherapy, 54 ((3)): (1232-1236). [PMID:20038624]
62. Adesh Dubey,S K Srivastava,S D Srivastava. (2010-12-07) Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: a new class of biological compounds.. Bioorganic & medicinal chemistry letters, 21 ((1)): (569-573). [PMID:21130647]
63. Steve P Bernier,David Lebeaux,Alicia S DeFrancesco,Amandine Valomon,Guillaume Soubigou,Jean-Yves Coppée,Jean-Marc Ghigo,Christophe Beloin. (2013-01-10) Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin.. PLoS genetics, 9 ((1)): (e1003144-e1003144). [PMID:23300476]
64. S Q Lew,A Gruia. (2013-01-26) Ofloxacin solution for persistent exit-site and tunnel infection in peritoneal dialysis.. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 33 ((1)): (101-102). [PMID:23349200]
65. T Matsumoto,T Inokuma,Y Imai. (2013-03-27) Education and imaging. Gastrointestinal: colonic mucosa-associated lymphoid tissue lymphoma regressed by levofloxacin.. Journal of gastroenterology and hepatology, 28 ((4)): (750-750). [PMID:23527757]
66. Saori Uoyama,Hiroko Kanda,Kumi Yoshida,Kazuki Hoshino. (2013-04-19) [Bactericidal effect of levofloxacin injection in combination with meropenem against Pseudomonas aeruginosa using an in vitro simulation model with a hollow fiber system].. The Japanese journal of antibiotics, 65 ((6)): (355-363). [PMID:23593732]
67. Mónica Lorente,Adrián Ballano,Adriana Juanes,Maria Antonia Pastor,Jesús Cuevas. (2013-07-05) Blue-gray pigmentation in trunk and extremities in a 71-year-old man.. JAMA dermatology, 149 ((9)): (1111-1112). [PMID:23824296]
68. Alexey A Makarov,Erik L Regalado,Christopher J Welch,Wes A Schafer. (2014-06-15) Effect of pressure on the chromatographic separation of enantiomers under reversed-phase conditions.. Journal of chromatography. A, 1352 (87-92). [PMID:24928149]
69. Guilian Li,Jingrui Zhang,Qian Guo,Yi Jiang,Jianhao Wei,Li-li Zhao,Xiuqin Zhao,Jianxin Lu,Kanglin Wan. (2015-02-20) Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates.. PloS one, 10 ((2)): (e0119013-e0119013). [PMID:25695504]
70. Xiaodan Jiang,Huibin Lv,Weiqiang Qiu,Ziyuan Liu,Xuemin Li,Wei Wang. (2015-06-26) Efficiency and safety of subconjunctival injection of anti-VEGF agent - bevacizumab - in treating dry eye.. Drug design, development and therapy, 9 (3043-3050). [PMID:26109847]
71. Milena Soares dos Santos,Jailton Azevedo,Ana Paula de Oliveria Menezes,Soraia Machado Cordeiro,Eliane Cunegundes Escobar,Josilene Borges Lima,Leila Carvalho Campos,Maria da Glória S Carvalho,Mitermayer G Reis,Albert I Ko,Joice Neves Reis. (2015-08-01) Temporal trends and clonal diversity of penicillin non-susceptible pneumococci from meningitis cases from 1996 to 2012, in Salvador, Brazil.. BMC infectious diseases, 15 (302-302). [PMID:26223380]
72. Eszter Deak,Robert Skov,Janet A Hindler,Romney M Humphries. (2015-08-21) Evaluation of Surrogate Disk Tests for Detection of Ciprofloxacin and Levofloxacin Resistance in Clinical Isolates of Salmonella enterica.. Journal of clinical microbiology, 53 ((11)): (3405-3410). [PMID:26292293]
73. Miklós D Resch,Elena Zemova,László Marsovszky,Nóra Szentmáry,Florian Bauer,Loay Daas,Max Pattmöller,Moatasem El-Husseiny,János Németh,Zoltán Z Nagy,Berthold Seitz. (2015-09-10) In Vivo Confocal Microscopic Imaging of the Cornea After Femtosecond and Excimer Laser-assisted Penetrating Keratoplasty.. Journal of refractive surgery (Thorofare, N.J. : 1995), 31 ((9)): (620-626). [PMID:26352568]
74. Marina Denadai,Quezia Bezerra Cass. (2015-10-03) Simultaneous determination of fluoroquinolones in environmental water by liquid chromatography-tandem mass spectrometry with direct injection: A green approach.. Journal of chromatography. A, 1418 (177-184). [PMID:26427326]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.