Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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O126519-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $9.90 | |
O126519-1g | 1g | In stock | $69.90 | |
O126519-5g | 5g | In stock | $231.90 | |
O126519-25g | 25g | In stock | $1,043.90 | |
O126519-100g | 100g | In stock | $3,755.90 |
Non-selective 5-HT, dopamine, histamine and muscarinic antagonist
Synonyms | NSC_4585 | Olanzapine Teva | 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine | OLANZAPINE [INN] | 2-methyl-4-(4-methyl-1-piperazinyl)-5H-thieno[3,2-c][1,5]benzodiazepine | BDBM82479 | OLANZAPINE (USP MONOGRAPH) | OLANZAPINE [V |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. It has a higher affinity for 5-HT2 serotonin receptors than D2 dopamine receptors. Like most atypical antipsychotics, compared to the older typical ones, olanz |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | D2-like dopamine receptor antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Olanzapine is an atypical antipsychotic drug, widely used for the treatment of acute schizophrenia and psychotic conditions. |
ALogP | 2.9 |
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Pubchem Sid | 488202827 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202827 |
IUPAC Name | 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine |
INCHI | InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 |
InChi Key | KVWDHTXUZHCGIO-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C |
Isomeric SMILES | CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C |
WGK Germany | 3 |
RTECS | XJ9007750 |
PubChem CID | 135398745 |
Molecular Weight | 312.43 |
Beilstein | 7655141 |
Reaxy-Rn | 7655141 |
PubChem CID | 135398745 |
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DrugBank Ligand | DB00334 |
CAS Registry No. | 132539-06-1 |
Wikipedia | Olanzapine |
BindingDB Ligand | 50053711 |
PEP | olanzapine |
GPCRdb Ligand | olanzapine |
PubChem SID | 488202827 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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A2214619 | Certificate of Analysis | Oct 08, 2023 | O126519 |
A2214620 | Certificate of Analysis | Oct 08, 2023 | O126519 |
C23241489 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241491 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241492 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241497 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241498 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241499 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241500 | Certificate of Analysis | Dec 10, 2022 | O126519 |
C23241501 | Certificate of Analysis | Dec 10, 2022 | O126519 |
G2423069 | Certificate of Analysis | Dec 10, 2022 | O126519 |
A2214621 | Certificate of Analysis | Dec 04, 2021 | O126519 |
Solubility | DMSO 100 mg/ml 1eq. HCl 100 mg/ml;Soluble in Acetronitrile |
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Sensitivity | Heat & light sensitive |
Melt Point(°C) | 192-196°C |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H336:May cause drowsiness or dizziness |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | XJ9007750 |
Reaxy-Rn | 7655141 |
Merck Index | 6822 |
1. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu. (2023) Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 234 (115557). [PMID:37406464] |
2. Kaikai Han, Jingjie Cui, Shaowei Chen, Tao Yu. (2023) Effects of olanzapine and lithium carbonate antipsychotic agents on dopamine oxidation. ANALYST, 148 (14): (3330-3340). [PMID:37350329] |
3. Lingzhi Liang, Xia Ren, Junyi Xu, Yurong Ma, Yunlin Xue, Tao Zhuang, Guisen Zhang. (2022) Effect of Co-Treatment of Olanzapine with SEP-363856 in Mice Models of Schizophrenia. MOLECULES, 27 (8): (2550). [PMID:35458749] |
4. Feifei Liang, Xiaofang Tan, Shuaishuai Hao, Wenwen Liu, Chenxin Duan, Guisen Zhang, Tao Zhuang, Yin Chen, Chao Hao. (2022) Synthesis and structural characterization of two novel olanzapine cocrystals with decreased or enhanced dissolution rate. JOURNAL OF MOLECULAR STRUCTURE, 1255 (132340). [PMID:] |
1. Nourian Z, Mow T, Muftic D, Burek S, Pedersen ML, Matz J, Mulvany MJ. (2008) Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function.. Psychopharmacology (Berl.), 199 (1): (15-27). [PMID:18542932] |
2. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu. (2023) Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 234 (115557). [PMID:37406464] |
3. Kaikai Han, Jingjie Cui, Shaowei Chen, Tao Yu. (2023) Effects of olanzapine and lithium carbonate antipsychotic agents on dopamine oxidation. ANALYST, 148 (14): (3330-3340). [PMID:37350329] |
4. Lingzhi Liang, Xia Ren, Junyi Xu, Yurong Ma, Yunlin Xue, Tao Zhuang, Guisen Zhang. (2022) Effect of Co-Treatment of Olanzapine with SEP-363856 in Mice Models of Schizophrenia. MOLECULES, 27 (8): (2550). [PMID:35458749] |
5. Feifei Liang, Xiaofang Tan, Shuaishuai Hao, Wenwen Liu, Chenxin Duan, Guisen Zhang, Tao Zhuang, Yin Chen, Chao Hao. (2022) Synthesis and structural characterization of two novel olanzapine cocrystals with decreased or enhanced dissolution rate. JOURNAL OF MOLECULAR STRUCTURE, 1255 (132340). [PMID:] |