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Omalizumab (anti-IgE) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IgE, >95%, high purity, Human IgG1, Antibody of immunoglobulin heavy constant epsilon

≥95%(SDS-PAGE&SEC)
Lot by Lot

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Application: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Species reactivity(Reacts with): Cynomolgus monkey,Human,Mouse,Rhesus monkey
Isotype: Human IgG1

Application:

Animal Model
ELISA
Flow Cytometry
Functional Assay

Item Number

Ab169258

Grouped product items
SKU	Size	Availability	Price
Ab169258-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
Ab169258-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$207.90
Ab169258-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$627.90
Ab169258-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$927.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Click to view target information: IGHE

Accession#:P01854 Gene ID:3497 IgE IGHE immunoglobulin heavy constant epsilon Antibody

Basic Description

Product Name	Omalizumab (anti-IgE) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IgE, >95%, high purity, Human IgG1
Synonyms	3-(2,2-Dimethylpropylidene)-2-methylidenecyclohexan-1-ol;3-(2,2-dimethylpropylidene)-4-methylidenecyclohexan-1-ol\|9024-00-4\|(1R,3E)-3-(2,2-dimethylpropylidene)-2-methylidenecyclohexan-1-ol;(1R,3Z)-3-(2,2-dimethylpropylidene)-2-methylidenecyclohexan-1-ol;(
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	IgE
Application	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of immunoglobulin heavy constant epsilon
Product Description	Omalizumab is a recombinant humanized monoclonal antibody to human immunoglobulin E (IgE) with KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptor and has a KD of 6.37 uM. Omalizumab has potential for use in studies of persistent allergic asthma. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	146.46 kDa
Purification Method	Protein A purified
Purity	>95%
Source	CHO supernatant
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	242138-07-4

Associated Targets(Human)

IGHE Tclin Immunoglobulin heavy constant epsilon (0 Activities)

Discover Target: IGHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IGHE Tclin Ig epsilon chain C region (0 Activities)

Discover Target: IGHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IMGT/mAb-DB

Wikipedia

Omalizumab

PEP

omalizumab

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0800945	Certificate of Analysis	Aug 30, 2023	Ab169258
ZJ23F0800944	Certificate of Analysis	Aug 30, 2023	Ab169258

References

1. Busse W, Corren J, Lanier BQ, McAlary M, Fowler-Taylor A, Cioppa GD, van As A, Gupta N. (2001) Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma.. J Allergy Clin Immunol, 108 (2): (184-90). [PMID:11496232]
2. Batista FD, Anand S, Presani G, Efremov DG, Burrone OR. (1996) The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors.. J Exp Med, 184 (6): (2197-205). [PMID:8976175]
3. Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, Kinet JP, Capron M. (1994) High-affinity IgE receptor on eosinophils is involved in defence against parasites.. Nature, 367 (6459): (183-6). [PMID:8114916]
4. Zhang, K K, Saxon, A A and Max, E E EE.. (1992) Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of epsilon heavy chain membrane exons.. The Journal of experimental medicine, (1): [PMID:1613458]
5. Pirron, U U, Schlunck, T T, Prinz, J C JC and Rieber, E P EP.. (1990) IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE.. European journal of immunology, [PMID:2167225]
6. Padlan, E A EA and Davies, D R DR.. (1986) A model of the Fc of immunoglobulin E.. Molecular immunology, [PMID:3796618]
7. Flanagan, J G JG and Rabbitts, T H TH.. (1982) The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.. The EMBO journal, [PMID:6234164]
8. Max, E E EE, Battey, J J, Ney, R R, Kirsch, I R IR and Leder, P P.. (1982) Duplication and deletion in the human immunoglobulin epsilon genes.. Cell, [PMID:6288268]
9. Seno, M M and 9 more authors.. (1983) Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA.. Nucleic acids research, (11): [PMID:6300763]
10. Ueda, S S, Nakai, S S, Nishida, Y Y, Hisajima, H H and Honjo, T T.. (1982) Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns.. The EMBO journal, [PMID:6327276]
11. Kenten, J H JH and 6 more authors.. (1982) Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6815656]
12. Vouldoukis, I I and 7 more authors.. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7544003]
13. Garman, S C SC, Wurzburg, B A BA, Tarchevskaya, S S SS, Kinet, J P JP and Jardetzky, T S TS.. (2000) Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.. Nature, (20): [PMID:10917520]
14. Heilig, Roland R and 98 more authors.. (2003) The DNA sequence and analysis of human chromosome 14.. Nature, (6): [PMID:12508121]
15. Hibbert, Richard G RG and 9 more authors.. (2005) The structure of human CD23 and its interactions with IgE and CD21.. The Journal of experimental medicine, (19): [PMID:16172256]
16. Schroeder, Harry W and Cavacini, Lisa.. (2010) Structure and function of immunoglobulins.. The Journal of allergy and clinical immunology, [PMID:20176268]
17. McHeyzer-Williams, Michael; Okitsu, Shinji; Wang, Nathaniel and McHeyzer-Williams, Louise.. (2011) Molecular programming of B cell memory.. Nature reviews. Immunology, (9): [PMID:22158414]
18. Joulia, Régis R and 6 more authors.. (2015) Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence.. Nature communications, (28): [PMID:25629393]

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