Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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O129581-2mg | 2mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
O129581-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $97.90 | |
O129581-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $162.90 | |
O129581-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $489.90 |
Synonyms | DTXSID901025949 | HMS3656F05 | BCP0726000250 | BCP9001023 | BCPP000140 | J-690376 | methyl 4-[[2-luoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate | MLS006011266 | CK-1827452;Omecamtiv mecarbil | CK1827452 | CK-1827452 | |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an EC50 of 0.6 μM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Cardiac myosin activator |
Note | 卖完停产,不再备货 |
ALogP | 1.4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate |
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INCHI | InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27) |
InChi Key | RFUBTTPMWSKEIW-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC |
Isomeric SMILES | CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC |
PubChem CID | 11689883 |
Molecular Weight | 401.43 |
PubChem CID | 11689883 |
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ChEMBL Ligand | CHEMBL1800955 |
CAS Registry No. | 873697-71-3 |
RCSB PDB Ligand | 2OW |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G1523065 | Certificate of Analysis | Feb 03, 2023 | O129581 |
Solubility | DMSO 80 mg/mL Water <1 mg/mL Ethanol 6 mg/mL |
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Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H372:Causes damage to organs through prolonged or repeated exposure H370:Causes damage to organs |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
1. Teerlink JR, Clarke CP, Saikali KG, Lee JH, Chen MM, Escandon RD, Elliott L, Bee R, Habibzadeh MR, Goldman JH et al.. (2011) Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study.. Lancet, 378 (9792): (667-75). [PMID:21856480] [10.1021/op500134e] |
2. Cleland JG, Teerlink JR, Senior R, Nifontov EM, Mc Murray JJ, Lang CC, Tsyrlin VA, Greenberg BH, Mayet J, Francis DP et al.. (2011) The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.. Lancet, 378 (9792): (676-83). [PMID:21856481] [10.1021/op500134e] |
3. Morgan BP, Muci A, Lu PP, Qian X, Tochimoto T, Smith WW, Garard M, Kraynack E, Collibee S, Suehiro I et al.. (2010) Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.. ACS Med Chem Lett, 1 (9): (472-7). [PMID:24900233] [10.1021/op500134e] |
4. Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Legg JC, Büchele G, Varin C, Kurtz CE et al.. (2020) Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF.. JACC Heart Fail, 8 (4): (329-340). [PMID:32035892] [10.1021/op500134e] |