Omecamtiv mecarbil (CK-1827452) - ≥98%, high purity , Cardiac myosin activator, CAS No.873697-71-3, Cardiac myosin activator

Item Number
O129581
Grouped product items
SKUSizeAvailabilityPrice Qty
O129581-2mg
2mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
O129581-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$97.90
O129581-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$162.90
O129581-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$489.90

Basic Description

SynonymsDTXSID901025949 | HMS3656F05 | BCP0726000250 | BCP9001023 | BCPP000140 | J-690376 | methyl 4-[[2-luoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate | MLS006011266 | CK-1827452;Omecamtiv mecarbil | CK1827452 | CK-1827452 |
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsOmecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an EC50 of 0.6 μM.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionCardiac myosin activator
Note卖完停产,不再备货

Product Properties

ALogP1.4

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aorta (2975 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate
INCHI InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)
InChi Key RFUBTTPMWSKEIW-UHFFFAOYSA-N
Canonical SMILES CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
Isomeric SMILES CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
PubChem CID 11689883
Molecular Weight 401.43

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
G1523065Certificate of AnalysisFeb 03, 2023 O129581

Chemical and Physical Properties

SolubilityDMSO 80 mg/mL Water <1 mg/mL Ethanol 6 mg/mL

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H372:Causes damage to organs through prolonged or repeated exposure

H370:Causes damage to organs

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P308+P316:IF exposed or concerned: Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

Related Documents

References

1. Teerlink JR, Clarke CP, Saikali KG, Lee JH, Chen MM, Escandon RD, Elliott L, Bee R, Habibzadeh MR, Goldman JH et al..  (2011)  Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study..  Lancet,  378  (9792): (667-75).  [PMID:21856480] [10.1021/op500134e]
2. Cleland JG, Teerlink JR, Senior R, Nifontov EM, Mc Murray JJ, Lang CC, Tsyrlin VA, Greenberg BH, Mayet J, Francis DP et al..  (2011)  The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial..  Lancet,  378  (9792): (676-83).  [PMID:21856481] [10.1021/op500134e]
3. Morgan BP, Muci A, Lu PP, Qian X, Tochimoto T, Smith WW, Garard M, Kraynack E, Collibee S, Suehiro I et al..  (2010)  Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin..  ACS Med Chem Lett,  (9): (472-7).  [PMID:24900233] [10.1021/op500134e]
4. Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Legg JC, Büchele G, Varin C, Kurtz CE et al..  (2020)  Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF..  JACC Heart Fail,  (4): (329-340).  [PMID:32035892] [10.1021/op500134e]

Solution Calculators