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ON-123300 - 98%, high purity , CAS No.1357470-29-1, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6;Inhibitor of NUAK family kinase 1
Basic Description Synonyms ON123300|1357470-29-1|ON-123300|narazaciclib|8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile|QJ8RO3296G|CHEMBL3115681|Pyrido(2,3-d)pyrimidine-6-carbonitrile, 8-cyclopentyl-7,8-dihydro-2-((4 Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6;Inhibitor of NUAK family kinase 1
Names and Identifiers IUPAC Name 8-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidine-6-carbonitrile INCHI InChI=1S/C24H27N7O/c1-29-10-12-30(13-11-29)20-8-6-19(7-9-20)27-24-26-16-18-14-17(15-25)23(32)31(22(18)28-24)21-4-2-3-5-21/h6-9,14,16,21H,2-5,10-13H2,1H3,(H,26,27,28) InChi Key VADOZMZXXRBXNY-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C=C(C(=O)N(C4=N3)C5CCCC5)C#N Isomeric SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C=C(C(=O)N(C4=N3)C5CCCC5)C#N Alternate CAS 1357470-29-1 PubChem CID 56649281 MeSH Entry Terms ON123300 Molecular Weight 429.5
Chemical and Physical Properties Solubility ≥21.5 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
References 1. Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R et al. . (2014) Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).. J Med Chem, 57 (3): (578-99). [PMID:24417566 ]
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I2203381