Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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O129694-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $58.90 | |
O129694-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $70.90 | |
O129694-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $319.90 | |
O129694-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,150.90 | |
O129694-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $5,175.90 | |
O129694-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $23,291.90 |
Selective 5-HT 3 antagonist
Synonyms | BRN 3622981 | HSDB 8304 | GR38032 | GR-38032 | GR-C507/75 | Zofran | AKOS016340526 | Odansetron (common misspelling of ondansetron) | ONDANSETRON (USP-RS) | 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)- | SPBio_0029 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Ondansetron is an antagonist of the SR (serotonin 5-HT3 receptor). Agonism of the SR (5-HT3 receptor) by Ondansetron has been correlated to anti-emetic effects.Highly potent and selective 5-HT 3 antagonist. Potent antiemetic in vivo . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Serotonin 3a (5-HT3a) receptor antagonist |
Note | 卖完停产,不再备货 Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic |
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IUPAC Name | 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one |
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INCHI | InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3 |
InChi Key | FELGMEQIXOGIFQ-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C |
Isomeric SMILES | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C |
PubChem CID | 4595 |
Molecular Weight | 293.36 |
PubChem CID | 4595 |
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ChEBI | CHEBI:7773 |
ChEMBL Ligand | CHEMBL46 |
DrugBank Ligand | DB00904 |
BindingDB Ligand | 50000493 |
Wikipedia | Ondansetron |
CAS Registry No. | 99614-02-5 |
PEP | ondansetron |
RCSB PDB Ligand | S87 |
DrugCentral Ligand | 1992 |
Enter Lot Number to search for COA:
Solubility | Soluble in DMSO (10 mg/mL, warm), water (partly miscible), and DMF. |
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Melt Point(°C) | 235-237°C |
Pictogram(s) | GHS06, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H362:May cause harm to breast-fed children |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
1. Yuanyuan Cai, Tao Dong, Xin Zhang, Aihua Liu. (2022) Morphology and Enzyme-Mimicking Activity of Copper Nanoassemblies Regulated by Peptide: Mechanism, Ultrasensitive Assaying of Trypsin, and Screening of Trypsin Inhibitors. ANALYTICAL CHEMISTRY, 94 (51): (18099–18106). [PMID:36515251] |
2. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan. (2023) Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 122 (110689). [PMID:36462602] |
3. Rimei Chen, Chao Zhao, Zhiping Chen, Xiaoyu Shi, Hongxiang Zhu, Qing Bu, Lei Wang, Chunfang Wang, Hui He. (2022) A bionic cellulose nanofiber-based nanocage wound dressing for NIR-triggered multiple synergistic therapy of tumors and infected wounds. BIOMATERIALS, 281 (121330). [PMID:34973556] |
1. Yuanyuan Cai, Tao Dong, Xin Zhang, Aihua Liu. (2022) Morphology and Enzyme-Mimicking Activity of Copper Nanoassemblies Regulated by Peptide: Mechanism, Ultrasensitive Assaying of Trypsin, and Screening of Trypsin Inhibitors. ANALYTICAL CHEMISTRY, 94 (51): (18099–18106). [PMID:36515251] |
2. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan. (2023) Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 122 (110689). [PMID:36462602] |
3. Rimei Chen, Chao Zhao, Zhiping Chen, Xiaoyu Shi, Hongxiang Zhu, Qing Bu, Lei Wang, Chunfang Wang, Hui He. (2022) A bionic cellulose nanofiber-based nanocage wound dressing for NIR-triggered multiple synergistic therapy of tumors and infected wounds. BIOMATERIALS, 281 (121330). [PMID:34973556] |