ONO-2333MS , Corticotropin releasing factor receptor 1 antagonist, CAS No.O612510, Corticotropin releasing factor receptor 1 antagonist

Item Number

O612510

Grouped product items
SKU	Size	Availability	Price	Qty
O612510-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
O612510-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,046.90

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Basic Description

Synonyms	ONO-2333 \| ONO-2333Ms \| T989JBG788 \| UNII-T989JBG788 \| 441060-02-2 \| CHEMBL1819077 \| (1-Ethyl-propyl)-(3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-S-indacen-8-yl)-amine \| 10-(2-Chloro-4-methoxyphenyl)-11- methyl-N-(pentan-3-yl)-1,8,12-triazatricy
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Corticotropin releasing factor receptor 1 antagonist

Associated Targets(Human)

CRHR1 Tclin Corticotropin-releasing factor receptor 1 (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

INCHI	InChI=1S/C22H27ClN4O/c1-5-14(6-2)24-21-17-8-7-9-19(17)25-22-20(13(3)26-27(21)22)16-11-10-15(28-4)12-18(16)23/h10-12,14,24H,5-9H2,1-4H3
InChi Key	LDIOUQIXNSSOGU-UHFFFAOYSA-N
Canonical SMILES	CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC
Isomeric SMILES	CCC(CC)NC1=C2CCCC2=NC3=C(C(=NN31)C)C4=C(C=C(C=C4)OC)Cl
PubChem CID	9801039

PubChem CID

BindingDB Ligand

ChEMBL Ligand

GPCRdb Ligand

References

1. Saito T, Obitsu T, Kondo T, Matsui T, Nagao Y, Kusumi K, Matsumura N, Ueno S, Kishi A, Katsumata S et al.. (2011) 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists.. Bioorg Med Chem, 19 (18): (5432-45). [PMID:21865047] [10.1021/op500134e]

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Basic Description