ONO-9054 , Prostanoid FP receptor agonist, CAS No.1262873-06-2, Prostanoid FP receptor agonist

Item Number

O612522

Grouped product items
SKU	Size	Availability	Price	Qty
O612522-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
O612522-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	Sepetaprost \| Sepetaprost [INN] \| ONO-9054 \| Sepetoprost \| UNII-79O7855J4G \| 79O7855J4G \| DE-126 \| 1262873-06-2 \| 2-Propanyl 4-((3S,5aR,6R,7R,8aS)-6-((1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-7-hydroxyoctahydro-2H-cyclopenta(b)oxepin-3-yl)butanoate \| 2H-Cyclopent
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Prostanoid FP receptor agonist

Associated Targets(Human)

PTGFR Tclin Prostaglandin F2-alpha receptor (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGFR Tclin Prostanoid FP receptor (687 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	propan-2-yl 4-[(3S,5aR,6R,7R,8aS)-6-[(E,3R)-4-(2,5-difluorophenoxy)-3-hydroxybut-1-enyl]-7-hydroxy-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate
INCHI	InChI=1S/C26H36F2O6/c1-16(2)34-26(31)5-3-4-17-6-9-21-20(23(30)13-24(21)32-14-17)10-8-19(29)15-33-25-12-18(27)7-11-22(25)28/h7-8,10-12,16-17,19-21,23-24,29-30H,3-6,9,13-15H2,1-2H3/b10-8+/t17-,19+,20+,21+,23+,24-/m0/s1
InChi Key	BKVUSNOUTQMSBE-XCMGCKIWSA-N
Canonical SMILES	CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C
Isomeric SMILES	CC(C)OC(=O)CCC[C@H]1CC[C@H]2[C@H](C[C@H]([C@@H]2/C=C/[C@H](COC3=C(C=CC(=C3)F)F)O)O)OC1
PubChem CID	50902259
Molecular Weight	482.6

PubChem CID

CAS Registry No.

DrugBank Ligand

GPCRdb Ligand

References

1. Miller Ellis E, Berlin MS, Ward CL, Sharpe JA, Jamil A, Harris A. (2017) Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study.. Br J Ophthalmol, 101 (6): (796-800). [PMID:27649982] [10.1021/op500134e]
2. Yamane S, Karakawa T, Nakayama S, Nagai K, Moriyuki K, Neki S, Suto F, Kambe T, Hirota Y, Kawabata K. (2015) IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys.. Invest Ophthalmol Vis Sci, 56 (4): (2547-52). [PMID:25788650] [10.1021/op500134e]
3. Harris A, Ward CL, Rowe-Rendleman CL, Ouchi T, Wood A, Fujii A, Serle JB. (2016) Ocular Hypotensive Effect of ONO-9054, an EP3/FP Receptor Agonist: Results of a Randomized, Placebo-controlled, Dose Escalation Study.. J Glaucoma, 25 (10): (e826-e833). [PMID:27300645] [10.1021/op500134e]
4. Klimko PG, Sharif NA. (2019) Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma.. Br J Pharmacol, 176 (8): (1051-1058). [PMID:29665040] [10.1021/op500134e]

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Basic Description