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ONO-AE3-208 - ≥98%, high purity , CAS No.402473-54-5, Antagonist of EP 3 receptor;Antagonist of EP 4 receptor
High affinity and selective EP4antagonist
Basic Description Synonyms ONO-AE3-208|402473-54-5|ONO AE3 208|4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic Acid|AE 3-208|4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid|4-(4-Cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido) Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of EP 3 receptor;Antagonist of EP 4 receptor Product Description ONO-AE3-208(AE 3-208) is an EP4 antagonist; suppresses cell invasion, migration, and metastasis of prostate cancer.
Product description：
ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer.
Names and Identifiers Pubchem Sid 488196540 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196540 IUPAC Name 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid INCHI InChI=1S/C24H21FN2O3/c1-15(18-11-12-21(25)20-7-3-2-6-19(18)20)24(30)27-22-13-16(14-26)9-10-17(22)5-4-8-23(28)29/h2-3,6-7,9-13,15H,4-5,8H2,1H3,(H,27,30)(H,28,29) InChi Key MTDIMKNAJUQTIO-UHFFFAOYSA-N Canonical SMILES CC(C1=CC=C(C2=CC=CC=C21)F)C(=O)NC3=C(C=CC(=C3)C#N)CCCC(=O)O Isomeric SMILES CC(C1=CC=C(C2=CC=CC=C21)F)C(=O)NC3=C(C=CC(=C3)C#N)CCCC(=O)O Alternate CAS 402473-54-5 PubChem CID 10111831 MeSH Entry Terms 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid;AE3 208;AE3-208;ONO AE3-208;ONO-AE3-208 Molecular Weight 404.43
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 40.44, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 4.04, Max Conc. mM: 10 with gentle warming
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D23191270