ONO-AE3-208 - ≥98%, high purity , CAS No.402473-54-5, Antagonist of EP 3 receptor;Antagonist of EP 4 receptor

Item Number

O125509

• Synonyms: NCGC00378671-02 | Q27088198 | 4-(4-Cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid | BCP29725 | AKOS024457689 | 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic Acid | ONO AE3 208 | ONO-AE3-208, >=98% (HPLC) | F
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: High affinity and selective EP4receptor antagonist (Kivalues are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki>10μM). Inhibits PGE2-induced IL-8 production in colonic ep
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of EP 3 receptor;Antagonist of EP 4 receptor

Product Description

ONO-AE3-208(AE 3-208) is an EP4 antagonist; suppresses cell invasion, migration, and metastasis of prostate cancer.

Product description：

ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer.