Grouped product items

SKU

Size

Availability

Price

Qty

O127572-5mg

5mg

In stock

$147.90

O127572-10mg

10mg

In stock

$236.90

O127572-25mg

25mg

In stock

$474.90

O127572-50mg

50mg

In stock

$741.90

O127572-100mg

100mg

In stock

$1,167.90

Basic Description

Synonyms	PR-957;ONX 0914;ONX0914;PR957;PR 957;N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Description: IC50 Value: ~10 nM [1] ONX-0914 (PR-957) is a potent and selectiveimmunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. in vitro: PR-957 blocked presentation of LMP7-specific
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of proteasome 20S subunit beta 8
Note	5mg、25mg卖完停产，不再备货
Product Description	ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.

Associated Targets(Human)

PSMB8 Tclin Proteasome subunit beta type-8 (1 Activities)

Discover Target: PSMB8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Caco-2 (12174 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Huh-7 (12904 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPMI-8226 (44974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PBMC (10003 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB2 Tclin Proteasome Macropain subunit (1025 Activities)

Discover Target: PSMB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)

Discover Target: PSMB5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB8 Tclin Proteasome subunit beta type-8 (743 Activities)

Discover Target: PSMB8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H727 (447 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB10 Tchem Proteasome subunit beta type-10 (258 Activities)

Discover Target: PSMB10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MM1.S (1111 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMA1 Tclin Proteasome subunit alpha type-1 (6 Activities)

Discover Target: PSMA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB4 Tbio Proteasome subunit beta type-4 (8 Activities)

Discover Target: PSMB4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRE7 Proteasome component C5 (37 Activities)

Discover Target: PRE7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Psmb9 Proteasome subunit beta type-9 (16 Activities)

Discover Target: Psmb9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Psmb5 Proteasome subunit beta type-5 (29 Activities)

Discover Target: Psmb5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Psmb2 Proteasome subunit beta type-2 (16 Activities)

Discover Target: Psmb2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRE3 Proteasome subunit beta type-1 (7 Activities)

Discover Target: PRE3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
INCHI	InChI=1S/C31H40N4O7/c1-21(32-27(36)19-35-13-15-41-16-14-35)29(38)34-26(18-23-9-11-24(40-3)12-10-23)30(39)33-25(28(37)31(2)20-42-31)17-22-7-5-4-6-8-22/h4-12,21,25-26H,13-20H2,1-3H3,(H,32,36)(H,33,39)(H,34,38)/t21-,25-,26-,31+/m0/s1
InChi Key	WQAVPPWWLLVGFK-VTNASVEKSA-N
Canonical SMILES	CC(C(=O)NC(CC1=CC=C(C=C1)OC)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(CO3)C)NC(=O)CN4CCOCC4
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4
PubChem CID	23642227
MeSH Entry Terms	(S)-3-(4-methoxyphenyl)-N-((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide;ONX 0914;PR-957
Molecular Weight	580.67

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot Number	Certificate Type	Date	Item
L2321289	Certificate of Analysis	Jan 02, 2024	O127572
G23131119	Certificate of Analysis	Mar 03, 2023	O127572
G23131120	Certificate of Analysis	Mar 03, 2023	O127572
G23131121	Certificate of Analysis	Mar 03, 2023	O127572
G23131122	Certificate of Analysis	Mar 03, 2023	O127572
G23131136	Certificate of Analysis	Mar 03, 2023	O127572
G23131137	Certificate of Analysis	Mar 03, 2023	O127572
G23131139	Certificate of Analysis	Mar 03, 2023	O127572
G23131140	Certificate of Analysis	Mar 03, 2023	O127572
G23131141	Certificate of Analysis	Mar 03, 2023	O127572
G1521067	Certificate of Analysis	Feb 03, 2023	O127572

Chemical and Physical Properties

Solubility	DMSO 100 mg/mL (172.21 mM);Water <1 mg/mL (<1 mM);Ethanol 100 mg/mL (172.21 mM)

References

1. Muchamuel T, Basler M, Aujay MA, Suzuki E, Kalim KW, Lauer C, Sylvain C, Ring ER, Shields J, Jiang J et al.. (2009) A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.. Nat Med, 15 (7): (781-7). [PMID:19525961]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

ONX-0914 (PR-957) - ≥98%, high purity , CAS No.960374-59-8, Inhibitor of proteasome 20S subunit beta 8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator