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OPC 21268 - ≥98%(HPLC), high purity , CAS No.131631-89-5, Antagonist of OT receptor;Antagonist of V 1A receptor;Antagonist of V 2 receptor

Moligand™

≥98%(HPLC)

CAS#: 131631-89-5
Formula: C₂₆H₃₁N₃O₄
Molecular Weight: 449.54
PubChem CID: 114904
PubChem SID: 488187520

Item Number

O287257

Grouped product items
SKU	Size	Availability	Price
O287257-5mg	5mg	In stock	$97.90
O287257-10mg	10mg	In stock	$129.90
O287257-25mg	25mg	In stock	$216.90
O287257-50mg	50mg	In stock	$303.90
O287257-100mg	100mg	In stock	$521.90

Vasotocin V1antagonist

View related series

OT receptor Antagonist V1A receptor Antagonist V2 receptor Antagonist

Basic Description

Synonyms	131631-89-5 \| Opc 21268 \| Fuscoside \| OPC-21268 \| 1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinone \| N-(3-(4-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide \| CHEMBL296908 \| Acetamide, N-[3-[4-[[4-(
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Nonpeptide Vasotocin V1receptor antagonist. Displays greater affinity for rat V1than human V1(Kivalues are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1receptors over V2receptors. Orally active.OPC-21268 is one of 2 non-peptide V1a s
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of OT receptor;Antagonist of V 1A receptor;Antagonist of V 2 receptor
Product Description	Product description： Fuscoside (OPC-21268) is an orally effective, nonpeptide, Vasotocin V1 receptor antagonist with an IC50 of 0.4 μM.

Associated Targets(Human)

AVPR1A Tclin Vasopressin V1a receptor (1 Activities)

Discover Target: AVPR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AVPR2 Tclin Vasopressin V2 receptor (1 Activities)

Discover Target: AVPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OXTR Tclin Oxytocin receptor (1 Activities)

Discover Target: OXTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)

Discover Target: AVPR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OXTR Tclin Oxytocin receptor (1962 Activities)

Discover Target: OXTR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

Discover Target: AVPR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Avpr1b Vasopressin V1 receptor (358 Activities)

Discover Target: Avpr1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488187520
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488187520
IUPAC Name	N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide
INCHI	InChI=1S/C26H31N3O4/c1-19(30)27-15-4-18-33-23-10-7-21(8-11-23)26(32)28-16-13-22(14-17-28)29-24-6-3-2-5-20(24)9-12-25(29)31/h2-3,5-8,10-11,22H,4,9,12-18H2,1H3,(H,27,30)
InChi Key	KSNUCNRMDYJBKT-UHFFFAOYSA-N
Canonical SMILES	CC(=O)NCCCOC1=CC=C(C=C1)C(=O)N2CCC(CC2)N3C(=O)CCC4=CC=CC=C43
Isomeric SMILES	CC(=O)NCCCOC1=CC=C(C=C1)C(=O)N2CCC(CC2)N3C(=O)CCC4=CC=CC=C43
PubChem CID	114904
Molecular Weight	449.54

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

GPCRdb Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
G2304771	Certificate of Analysis	May 19, 2023	O287257
G2304772	Certificate of Analysis	May 19, 2023	O287257
G2304773	Certificate of Analysis	May 19, 2023	O287257
G2304774	Certificate of Analysis	May 19, 2023	O287257
G2304775	Certificate of Analysis	May 19, 2023	O287257
G2304776	Certificate of Analysis	May 19, 2023	O287257
G2304872	Certificate of Analysis	May 19, 2023	O287257
G2304876	Certificate of Analysis	May 19, 2023	O287257
G2304877	Certificate of Analysis	May 19, 2023	O287257
G2304881	Certificate of Analysis	May 19, 2023	O287257

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

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