Hypothalamic neuropeptide involved in the regulation of feeding, sleep and wakefulness.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of OX 1 receptor;Agonist of OX 2 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Hirtz C, Vialaret J, Gabelle A, Nowak N, Dauvilliers Y, Lehmann S. (2016) From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid.. Sci Rep, 6 (3):(25162). [PMID:27165941]
2.Lindström M, Schinkelshoek M, Tienari PJ, Kukkonen JP, Renkonen R, Fronczek R, Lammers GJ, Itkonen O. (2021) Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays.. Clin Biochem, 90 (3):(34-39). [PMID:33539807]
3.Bårdsen K, Gjerstad MD, Partinen M, Kvivik I, Tjensvoll AB, Ruoff P, Omdal R, Brede C. (2019) Considerably Lower Levels of Hypocretin-1 in Cerebrospinal Fluid Is Revealed by a Novel Mass Spectrometry Method Compared with Standard Radioimmunoassay.. Anal Chem, 91 (14):(9323-9329). [PMID:31260261]
4.Guo F et al.. (2019) Effect of orexin-A in the arcuate nucleus on cisplatin-induced gastric side effects in rats.. Neurosci Res, 143 (53-60). [PMID:29879461]
5.Li T et al.. (2020) Orexin A alleviates neuroinflammation via OXR2/CaMKKß/AMPK signaling pathway after ICH in mice.. J Neuroinflammation, 17 (187). [PMID:32539736]
6.Xiao X et al.. (2021) Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.. Nat Commun, 12 (5249). [PMID:34475397]
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