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Orexin A (bovine, human, mouse, rat) - ≥90%, high purity , CAS No.205640-90-0, Agonist of OX 1 receptor;Agonist of OX 2 receptor

Specifications & Purity:  ≥90%
Item Number
O275498
Grouped product items
SKUSizeAvailabilityPrice Qty
O275498-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$319.90
O275498-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,071.90
O275498-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$783.90

Neuropeptide involved in feeding and sleep

Basic Description

SynonymsOrexin A (human, rat, mouse)
Specifications & Purity≥90%
Storage TempStore at -20°C,Desiccated
Shipped InDry ice
Action TypeAGONIST
Mechanism of actionAgonist of OX 1 receptor;Agonist of OX 2 receptor

Associated Targets

HCRTR1 Tclin Orexin receptor type 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HCRTR2 Tclin Orexin receptor type 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Molecular Weight 3561.12

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in water to 1mg/ml

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References

1. Hirtz C, Vialaret J, Gabelle A, Nowak N, Dauvilliers Y, Lehmann S.  (2016)  From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid..  Sci Rep,  (3): (25162).  [PMID:27165941]
2. Lindström M, Schinkelshoek M, Tienari PJ, Kukkonen JP, Renkonen R, Fronczek R, Lammers GJ, Itkonen O.  (2021)  Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays..  Clin Biochem,  90  (3): (34-39).  [PMID:33539807]
3. Bårdsen K, Gjerstad MD, Partinen M, Kvivik I, Tjensvoll AB, Ruoff P, Omdal R, Brede C.  (2019)  Considerably Lower Levels of Hypocretin-1 in Cerebrospinal Fluid Is Revealed by a Novel Mass Spectrometry Method Compared with Standard Radioimmunoassay..  Anal Chem,  91  (14): (9323-9329).  [PMID:31260261]
4. Guo F et al..  (2019)  Effect of orexin-A in the arcuate nucleus on cisplatin-induced gastric side effects in rats..  Neurosci Res,  143  (53-60).  [PMID:29879461]
5. Li T et al..  (2020)  Orexin A alleviates neuroinflammation via OXR2/CaMKKß/AMPK signaling pathway after ICH in mice..  J Neuroinflammation,  17  (187).  [PMID:32539736]
6. Xiao X et al..  (2021)  Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity..  Nat Commun,  12  (5249).  [PMID:34475397]

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