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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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O275498-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $319.90 | |
O275498-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,071.90 | |
O275498-500μg | 500μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $783.90 |
Neuropeptide involved in feeding and sleep
Synonyms | Orexin A (human, rat, mouse) |
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Specifications & Purity | ≥90% |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Dry ice |
Action Type | AGONIST |
Mechanism of action | Agonist of OX 1 receptor;Agonist of OX 2 receptor |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Molecular Weight | 3561.12 |
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UniProtKB | O43612, O55241, O55232 |
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CAS Registry No. | 205640-90-0 |
Wikipedia | Orexin-A |
Ensembl Gene | ENSG00000161610, ENSMUSG00000045471, ENSRNOG00000018892 |
GPCRdb Ligand | orexin-A |
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Solubility | Soluble in water to 1mg/ml |
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1. Hirtz C, Vialaret J, Gabelle A, Nowak N, Dauvilliers Y, Lehmann S. (2016) From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid.. Sci Rep, 6 (3): (25162). [PMID:27165941] |
2. Lindström M, Schinkelshoek M, Tienari PJ, Kukkonen JP, Renkonen R, Fronczek R, Lammers GJ, Itkonen O. (2021) Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays.. Clin Biochem, 90 (3): (34-39). [PMID:33539807] |
3. Bårdsen K, Gjerstad MD, Partinen M, Kvivik I, Tjensvoll AB, Ruoff P, Omdal R, Brede C. (2019) Considerably Lower Levels of Hypocretin-1 in Cerebrospinal Fluid Is Revealed by a Novel Mass Spectrometry Method Compared with Standard Radioimmunoassay.. Anal Chem, 91 (14): (9323-9329). [PMID:31260261] |
4. Guo F et al.. (2019) Effect of orexin-A in the arcuate nucleus on cisplatin-induced gastric side effects in rats.. Neurosci Res, 143 (53-60). [PMID:29879461] |
5. Li T et al.. (2020) Orexin A alleviates neuroinflammation via OXR2/CaMKKß/AMPK signaling pathway after ICH in mice.. J Neuroinflammation, 17 (187). [PMID:32539736] |
6. Xiao X et al.. (2021) Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.. Nat Commun, 12 (5249). [PMID:34475397] |