JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Org 20599 , CAS No.156685-94-8

Item Number

O287142

Grouped product items
SKU	Size	Availability	Price	Qty
O287142-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$144.90
O287142-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$603.90

Positive allosteric modulator of GABAAreceptors; direct agonist at higher concentrations

View related series

Basic Description

Synonyms	2-Chloro-1-[(1S,3aS,3bR,5aS,7S,8S,9aS,9bS,11aS)-7-hydroxy-9a,11a-dimethyl-8-(4-morpholinyl)hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]ethanone \| AKOS024457271 \| HY-103498 \| org20599 \| ORG 20599 \| CS-0028000 \| (2beta,3alpha,5alpha)-21-chloro-3-hydroxy-
Biochemical and Physiological Mechanisms	Positive allosteric modulator and at higher concentrations direct agonist of GABAAreceptors (EC50= 1.1μM). Also displays positive modulation of glycine receptors (EC50= 22.9μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
Storage Temp	Room temperature
Shipped In	Normal

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	2-chloro-1-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
INCHI	InChI=1S/C25H40ClNO3/c1-24-8-7-19-17(18(24)5-6-20(24)23(29)15-26)4-3-16-13-22(28)21(14-25(16,19)2)27-9-11-30-12-10-27/h16-22,28H,3-15H2,1-2H3/t16-,17-,18-,19-,20+,21-,22-,24-,25-/m0/s1
InChi Key	NZFNABGZEQPYBX-PMBZPZLSSA-N
Canonical SMILES	CC12CCC3C(C1CCC2C(=O)CCl)CCC4C3(CC(C(C4)O)N5CCOCC5)C
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CCl)CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C
PubChem CID	9850026
Molecular Weight	438.04

Enter Lot Number to search for COA:

Solubility	Solvent:1eq. HCl, Max Conc. mg/mL: 43.8, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 43.8, Max Conc. mM: 100

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.