Org 20599 , CAS No.156685-94-8

Item Number

O287142

Grouped product items
SKU	Size	Availability	Price	Qty
O287142-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$144.90
O287142-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$603.90

Positive allosteric modulator of GABAAreceptors; direct agonist at higher concentrations

Basic Description

Synonyms	ORG 20599\|156685-94-8\|org20599\|SCHEMBL7351329\|CHEMBL3137825\|DTXSID30349651\|AKOS024457271\|Pregnan-20-one, 21-chloro-3-hydroxy-2-(4-morpholinyl)-, (2b,3a,5a)-\|HY-103498\|CS-0028000\|J-009331\|(2?,3?,5?)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one\|(2bet
Biochemical and Physiological Mechanisms	Positive allosteric modulator and at higher concentrations direct agonist of GABAAreceptors (EC50= 1.1μM). Also displays positive modulation of glycine receptors (EC50= 22.9μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
Storage Temp	Room temperature
Shipped In	Normal

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-chloro-1-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
INCHI	InChI=1S/C25H40ClNO3/c1-24-8-7-19-17(18(24)5-6-20(24)23(29)15-26)4-3-16-13-22(28)21(14-25(16,19)2)27-9-11-30-12-10-27/h16-22,28H,3-15H2,1-2H3/t16-,17-,18-,19-,20+,21-,22-,24-,25-/m0/s1
InChi Key	NZFNABGZEQPYBX-PMBZPZLSSA-N
Canonical SMILES	CC12CCC3C(C1CCC2C(=O)CCl)CCC4C3(CC(C(C4)O)N5CCOCC5)C
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CCl)CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C
PubChem CID	9850026
Molecular Weight	438.04

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Basic Description