Oridonin - analytical standard,≥98%, high purity , CAS No.28957-04-2

Item Number
O111381
Grouped product items
SKUSizeAvailabilityPrice Qty
O111381-20mg
20mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$102.90

Basic Description

SynonymsORIDONIN [INCI] | NSC-250682; Isodonol | Rubescenin | DTXSID201021760 | KAUR-16-EN-15-ONE, 7,20-EPOXY-1,6,7,14-TETRAHYDROXY-, (1.ALPHA.,6.BETA.,7.ALPHA.,14R)- | CHEBI:138236 | 0APJ98UCLQ | Oridonin | UNII-0APJ98UCLQ | CS-0007086 | H10339 | NSC 250682 | Cu
Specifications & Purityanalytical standard, ≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
Gradeanalytical standard

Associated Targets(Human)

HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB 3-1 (1143 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-453 (1139 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SGC-7901 (2773 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-BR-3 (5175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bel-7402 (4577 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BEL-7404 tumor cell line (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBMC (10003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMMC-7721 (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC1806 (544 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC1937 (423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLC-PRF-5 (244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NLRP3 Tchem NACHT, LRR and PYD domains-containing protein 3 (908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TE-1 (337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-4475 (193 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGC-803 (6426 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L02 (4864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H22 (575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one
INCHI InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
InChi Key SDHTXBWLVGWJFT-XKCURVIJSA-N
Canonical SMILES CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
Isomeric SMILES CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C
WGK Germany 2
RTECS NZ8177000
Alternate CAS 28957-10-0
PubChem CID 5321010
Molecular Weight 364.43

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
I2208866Certificate of AnalysisJun 19, 2024 O111381
L2103141Certificate of AnalysisSep 18, 2023 O111381
H2124452Certificate of AnalysisMay 12, 2023 O111381
G1918089Certificate of AnalysisFeb 06, 2023 O111381

Chemical and Physical Properties

Melt Point(°C)248-250°C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements

H351:Suspected of causing cancer

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

WGK Germany 2
RTECS NZ8177000

Related Documents

Citations of This Product

1. Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen.  (2023)  In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model.  MOLECULES,  28  (23): (7701).  [PMID:38067432] [10.3390/molecules28237701]
2. Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan.  (2023)  Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis.  Cell Death & Disease,  14  (2): (1-17).  [PMID:36746922] [10.1038/s41419-023-05613-6]
3. Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying.  (2022)  Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis.  Genes,  13  (11): (2133).  [PMID:36421808] [10.3390/genes13112133]
4. Linglan Yang, Leitao Zhang, Jing Hu, Wenjin Wang, Xiqiang Liu.  (2021)  Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  166  (166).  [PMID:33172616] [10.1016/j.ijbiomac.2020.10.129]
5. Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen.  (2020)  Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  24  (8): (4480-4493).  [PMID:32168416] [10.1111/jcmm.15106]
6. Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li.  (2020)  Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.  PHARMACEUTICAL BIOLOGY,  58  (1): (146-151).  [PMID:31971852] [10.1080/13880209.2020.1711783]
7. Heqi Bu, Dianlei Liu, Junhui Cui, Ke Cai, Feng Shen.  (2019)  Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells.  Translational Cancer Research,  (5): ( 1782–1794).  [PMID:35116929] [10.21037/tcr.2019.08.25]
8. Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang.  (2018)  Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation.  Oncology Letters,  15  (3): (2881-2888).  [PMID:29435014] [10.3892/ol.2017.7665]
9. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng.  (2014)  Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs.  FOOD CHEMISTRY,  164  (74).  [PMID:24996308] [10.1016/j.foodchem.2014.05.004]

References

1. Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen.  (2023)  In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model.  MOLECULES,  28  (23): (7701).  [PMID:38067432] [10.3390/molecules28237701]
2. Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan.  (2023)  Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis.  Cell Death & Disease,  14  (2): (1-17).  [PMID:36746922] [10.1038/s41419-023-05613-6]
3. Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying.  (2022)  Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis.  Genes,  13  (11): (2133).  [PMID:36421808] [10.3390/genes13112133]
4. Linglan Yang, Leitao Zhang, Jing Hu, Wenjin Wang, Xiqiang Liu.  (2021)  Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  166  (166).  [PMID:33172616] [10.1016/j.ijbiomac.2020.10.129]
5. Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen.  (2020)  Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  24  (8): (4480-4493).  [PMID:32168416] [10.1111/jcmm.15106]
6. Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li.  (2020)  Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.  PHARMACEUTICAL BIOLOGY,  58  (1): (146-151).  [PMID:31971852] [10.1080/13880209.2020.1711783]
7. Heqi Bu, Dianlei Liu, Junhui Cui, Ke Cai, Feng Shen.  (2019)  Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells.  Translational Cancer Research,  (5): ( 1782–1794).  [PMID:35116929] [10.21037/tcr.2019.08.25]
8. Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang.  (2018)  Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation.  Oncology Letters,  15  (3): (2881-2888).  [PMID:29435014] [10.3892/ol.2017.7665]
9. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng.  (2014)  Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs.  FOOD CHEMISTRY,  164  (74).  [PMID:24996308] [10.1016/j.foodchem.2014.05.004]

Solution Calculators