Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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O111381-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $102.90 |
Synonyms | ORIDONIN [INCI] | NSC-250682; Isodonol | Rubescenin | DTXSID201021760 | KAUR-16-EN-15-ONE, 7,20-EPOXY-1,6,7,14-TETRAHYDROXY-, (1.ALPHA.,6.BETA.,7.ALPHA.,14R)- | CHEBI:138236 | 0APJ98UCLQ | Oridonin | UNII-0APJ98UCLQ | CS-0007086 | H10339 | NSC 250682 | Cu |
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Specifications & Purity | analytical standard, ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one |
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INCHI | InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1 |
InChi Key | SDHTXBWLVGWJFT-XKCURVIJSA-N |
Canonical SMILES | CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C |
Isomeric SMILES | CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C |
WGK Germany | 2 |
RTECS | NZ8177000 |
Alternate CAS | 28957-10-0 |
PubChem CID | 5321010 |
Molecular Weight | 364.43 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2208866 | Certificate of Analysis | Jun 19, 2024 | O111381 |
L2103141 | Certificate of Analysis | Sep 18, 2023 | O111381 |
H2124452 | Certificate of Analysis | May 12, 2023 | O111381 |
G1918089 | Certificate of Analysis | Feb 06, 2023 | O111381 |
Melt Point(°C) | 248-250°C |
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Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H351:Suspected of causing cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 2 |
RTECS | NZ8177000 |
1. Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen. (2023) In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model. MOLECULES, 28 (23): (7701). [PMID:38067432] [10.3390/molecules28237701] |
2. Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan. (2023) Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis. Cell Death & Disease, 14 (2): (1-17). [PMID:36746922] [10.1038/s41419-023-05613-6] |
3. Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying. (2022) Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis. Genes, 13 (11): (2133). [PMID:36421808] [10.3390/genes13112133] |
4. Linglan Yang, Leitao Zhang, Jing Hu, Wenjin Wang, Xiqiang Liu. (2021) Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 166 (166). [PMID:33172616] [10.1016/j.ijbiomac.2020.10.129] |
5. Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen. (2020) Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (8): (4480-4493). [PMID:32168416] [10.1111/jcmm.15106] |
6. Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li. (2020) Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes. PHARMACEUTICAL BIOLOGY, 58 (1): (146-151). [PMID:31971852] [10.1080/13880209.2020.1711783] |
7. Heqi Bu, Dianlei Liu, Junhui Cui, Ke Cai, Feng Shen. (2019) Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells. Translational Cancer Research, 8 (5): ( 1782–1794). [PMID:35116929] [10.21037/tcr.2019.08.25] |
8. Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang. (2018) Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation. Oncology Letters, 15 (3): (2881-2888). [PMID:29435014] [10.3892/ol.2017.7665] |
9. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |
1. Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen. (2023) In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model. MOLECULES, 28 (23): (7701). [PMID:38067432] [10.3390/molecules28237701] |
2. Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan. (2023) Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis. Cell Death & Disease, 14 (2): (1-17). [PMID:36746922] [10.1038/s41419-023-05613-6] |
3. Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying. (2022) Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis. Genes, 13 (11): (2133). [PMID:36421808] [10.3390/genes13112133] |
4. Linglan Yang, Leitao Zhang, Jing Hu, Wenjin Wang, Xiqiang Liu. (2021) Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 166 (166). [PMID:33172616] [10.1016/j.ijbiomac.2020.10.129] |
5. Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen. (2020) Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (8): (4480-4493). [PMID:32168416] [10.1111/jcmm.15106] |
6. Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li. (2020) Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes. PHARMACEUTICAL BIOLOGY, 58 (1): (146-151). [PMID:31971852] [10.1080/13880209.2020.1711783] |
7. Heqi Bu, Dianlei Liu, Junhui Cui, Ke Cai, Feng Shen. (2019) Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells. Translational Cancer Research, 8 (5): ( 1782–1794). [PMID:35116929] [10.21037/tcr.2019.08.25] |
8. Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang. (2018) Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation. Oncology Letters, 15 (3): (2881-2888). [PMID:29435014] [10.3892/ol.2017.7665] |
9. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |