Basic Description

Synonyms	Oridonin\|28957-04-2\|Oridonine\|ISODONOL\|Rubescensin A\|0APJ98UCLQ\|CHEMBL1164920\|Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1alpha,6beta,7alpha,14R)-\|Rubescensin\|NSC-250682\|PURE ORIDONIN\|NSC-250682; Isodonol\|UNII-0APJ98UCLQ\|Rubescenin\|NSC 250682\|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Antitumor agent (IC 50 = 7.4 μM). Shows apoptotic, antiangiogenic and antiproliferative activity in vitro . Inhibits NF-κB activity and downregualtes BCL-xL. Active in vivo . Cell-permeable.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one
INCHI	InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
InChi Key	SDHTXBWLVGWJFT-XKCURVIJSA-N
Canonical SMILES	CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
Isomeric SMILES	CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C
WGK Germany	2
RTECS	NZ8177000
Alternate CAS	28957-10-0
PubChem CID	5321010
Molecular Weight	364.43

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1 results found

Lot Number	Certificate Type	Date	Item
I2208867	Certificate of Analysis	Sep 15, 2022	O111382

Melt Point(°C)	248-250°C

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H351:Suspected of causing cancer
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice.
WGK Germany	2
RTECS	NZ8177000

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