Antitumor agent (IC 50 = 7.4 μM). Shows apoptotic, antiangiogenic and antiproliferative activity in vitro . Inhibits NF-κB activity and downregualtes BCL-xL. Active in vivo . Cell-permeable.
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen. (2023) In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model. MOLECULES, 28 (23):(7701). [PMID:38067432]
2.Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan. (2023) Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis. Cell Death & Disease, 14 (2):(1-17). [PMID:36746922]
3.Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying. (2022) Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis. Genes, 13 (11):(2133). [PMID:36421808]
References
1.Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen. (2023) In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model. MOLECULES, 28 (23):(7701). [PMID:38067432]
2.Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan. (2023) Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis. Cell Death & Disease, 14 (2):(1-17). [PMID:36746922]
3.Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying. (2022) Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis. Genes, 13 (11):(2133). [PMID:36421808]
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I2208867