Orlistat - >97.0%(HPLC), high purity , Pancreatic lipase inhibitor, CAS No.96829-58-2, Pancreatic lipase inhibitor

Item Number

O159936

• Synonyms: CCG-100851 | DTXCID40820067 | ORLISTAT [MART.] | Orlistat, United States Pharmacopeia (USP) Reference Standard | Q424163 | [(2S)-1-[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2R)-2-formamido-4-methylpentanoate | BDBM24567 | HSDB 7556 | L-Leucine, N-
• Specifications & Purity: Moligand™, ≥97%(HPLC)
• Biochemical and Physiological Mechanisms: Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.Selective, competitive lipase inhibitor (IC 50 = 0.15 µM). Displays antiproliferative and antitumor activity. Active in
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Pancreatic lipase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.
Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice