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Orteronel - ≥99%, high purity , Cytochrome P450 17A1 inhibitor, CAS No.566939-85-3, Cytochrome P450 17A1 inhibitor
Basic Description Synonyms Orteronel | 566939-85-3 | TAK 700 | TAK-700 | (S)-Orteronel | (S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide | UE5K2FNS92 | TAK700 | CHEMBL1921976 | 566939-85-3 (s-isomer) | 6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-meth Specifications & Purity ≥99% Biochemical and Physiological Mechanisms TAK-700 shows potent inhibitory activity against rat, monkey, and human steroid 17,20-lyase inhibitor with IC50 of 54 nM, 27 nM, and 38 nM, respectively. In monkey adrenal cells, TAK-700 inhibits the ACTH stimulated production of DHEA and androstenedione Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Cytochrome P450 17A1 inhibitor Product Description Orteronel(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide INCHI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1 InChi Key OZPFIJIOIVJZMN-SFHVURJKSA-N Canonical SMILES CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O Isomeric SMILES CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)[C@]3(CCN4C3=CN=C4)O PubChem CID 9796590 Molecular Weight 307.35
Chemical and Physical Properties Solubility DMSO ≥60mg/mL;Water <1.2mg/mL;Ethanol ≥60mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H372: Causes damage to organs through prolonged or repeated exposure
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
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