OSI-930 - 98%, high purity , CAS No.728033-96-3, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;Inhibitor of Raf-1 proto-oncogene; serine/threonine

Item Number

O126155

Grouped product items
SKU	Size	Availability	Price
O126155-1mg	1mg	In stock	$60.90
O126155-5mg	5mg	In stock	$129.90
O126155-10mg	10mg	In stock	$214.90
O126155-25mg	25mg	In stock	$483.90
O126155-50mg	50mg	In stock	$703.90
O126155-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,267.90

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Basic Description

Synonyms	OSI-930\|728033-96-3\|OSI 930\|OSI930\|3-((quinolin-4-ylmethyl)amino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide\|3-(quinolin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide\|3-(quinolin-4-ylmethylamino)-N-[4-(trifluoromethoxy)
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	OSI-930 is an inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of colony stimulating factor 1 receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;Inhibitor of Raf-1 proto-oncogene; serine/threonine

Names and Identifiers

IUPAC Name	3-(quinolin-4-ylmethylamino)-N-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxamide
INCHI	InChI=1S/C22H16F3N3O2S/c23-22(24,25)30-16-7-5-15(6-8-16)28-21(29)20-19(10-12-31-20)27-13-14-9-11-26-18-4-2-1-3-17(14)18/h1-12,27H,13H2,(H,28,29)
InChi Key	FGTCROZDHDSNIO-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F
Isomeric SMILES	C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F
Alternate CAS	728033-96-3
PubChem CID	9868037
MeSH Entry Terms	N-(4-trifluoromethoxyphenyl)3-((quinolin-4-ylmethyl)amino)thiophene-2-carboxamide;OSI 930;OSI-930;OSI930
Molecular Weight	443.45

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
A2211389	Certificate of Analysis	Oct 11, 2023	O126155
A2211391	Certificate of Analysis	Oct 11, 2023	O126155
A2211428	Certificate of Analysis	Oct 11, 2023	O126155
A2211434	Certificate of Analysis	Oct 11, 2023	O126155
A2211598	Certificate of Analysis	Oct 11, 2023	O126155
A2211675	Certificate of Analysis	Oct 11, 2023	O126155

References

1. Garton AJ, Crew AP, Franklin M, Cooke AR, Wynne GM, Castaldo L, Kahler J, Winski SL, Franks A, Brown EN et al.. (2006) OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models.. Cancer Res, 66 (2): (1015-24). [PMID:16424037]

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Basic Description