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Ospemifene - ≥98.0%, high purity , Estrogen receptor modulator, CAS No.128607-22-7, Estrogen receptor modulator

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Ospemifene - ≥98.0%, high purity , Estrogen receptor modulator, CAS No.128607-22-7, Estrogen receptor modulator

Moligand™

≥98%

CAS#: 128607-22-7
Formula: C₂₄H₂₃ClO₂
Molecular Weight: 378.9
PubChem CID: 3036505

Item Number

O159905

Grouped product items
SKU	Size	Availability	Price
O159905-50mg	50mg	In stock	$90.90
O159905-250mg	250mg	In stock	$409.90
O159905-1g	1g	In stock	$1,474.90
O159905-5g	5g	In stock	$6,633.90

View related series

Estrogen receptor-α Antagonist Estrogen receptor-β Antagonist Estrogen Receptor/ERR Vitamin D Related/Nuclear Receptor

Basic Description

Synonyms	CS-5961 \| J-005613 \| Ophena \| senshio \| CCRIS 9205 \| Q7107372 \| A14261 \| 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol \| Fc-1271 \| Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]- \| OSPEMIFENE [ORANGE BOOK] \| B0P231ILBK \| MFCD0087
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, MODULATOR
Mechanism of action	Estrogen receptor modulator
Product Description	Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

Product Properties

ALogP	6.5

Associated Targets(Human)

ESR1 Tclin Estrogen receptor (0 Activities)

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR2 Tclin Estrogen receptor beta (0 Activities)

Discover Target: ESR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCF7 (126967 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEF (1005 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Marburgvirus (118 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol
INCHI	InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
InChi Key	LUMKNAVTFCDUIE-VHXPQNKSSA-N
Canonical SMILES	C1=CC=C(C=C1)C(=C(C2=CC=CC=C2)C3=CC=C(C=C3)OCCO)CCCl
Isomeric SMILES	C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C3=CC=C(C=C3)OCCO)/CCCl
WGK Germany	3
PubChem CID	3036505
Molecular Weight	378.9
Reaxy-Rn	10283864

Database links

ChEMBL Ligand	CHEMBL2105395
PubChem CID	3036505
Wikipedia	Ospemifene
CAS Registry No.	128607-22-7
DrugBank Ligand	DB04938
DrugCentral Ligand	4749

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
I2219106	Certificate of Analysis	Aug 11, 2022	O159905
I2219108	Certificate of Analysis	Aug 11, 2022	O159905
I2219332	Certificate of Analysis	Aug 11, 2022	O159905
F2214257	Certificate of Analysis	Oct 12, 2021	O159905

Chemical and Physical Properties

Solubility	Chloroform (Slightly), Methanol (Slightly)
Melt Point(°C)	115-117°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H411:Toxic to aquatic life with long lasting effects H318:Causes serious eye damage H302+H312:Harmful if swallowed or in contact with skin
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312+P330:IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
WGK Germany	3
Reaxy-Rn	10283864

References

1. Rutanen EM, Heikkinen J, Halonen K, Komi J, Lammintausta R, Ylikorkala O. (2003) Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial.. Menopause, 10 (5): (433-9). [PMID:14501605] [10.1021/op500134e]
2. Unkila M, Kari S, Yatkin E, Lammintausta R. (2013) Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause.. J Steroid Biochem Mol Biol, 138 (13): (107-15). [PMID:23665515] [10.1021/op500134e]
3. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.. Biochim Biophys Acta, 1812 (8): (982-94). [PMID:21193033] [10.1021/op500134e]

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Ospemifene - ≥98.0%, high purity , Estrogen receptor modulator, CAS No.128607-22-7, Estrogen receptor modulator

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator