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Ospemifene - ≥98.0%, high purity , Estrogen receptor modulator, CAS No.128607-22-7, Estrogen receptor modulator

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Ospemifene - ≥98.0%, high purity , Estrogen receptor modulator, CAS No.128607-22-7, Estrogen receptor modulator

Moligand™
≥98%

CAS#: 128607-22-7
Formula: C₂₄H₂₃ClO₂
Molecular Weight: 378.9
PubChem CID: 3036505

Item Number

O159905

Grouped product items
SKU	Size	Availability	Price
O159905-50mg	50mg	In stock	$90.90
O159905-250mg	250mg	In stock	$409.90
O159905-1g	1g	In stock	$1,474.90
O159905-5g	5g	In stock	$6,633.90

View related series

Estrogen receptor-α Antagonist Estrogen receptor-β Antagonist

Basic Description

Synonyms	Ospemifene\|128607-22-7\|FC-1271a\|Osphena\|senshio\|Deamino-hydroxytoremifene\|Fc-1271\|Tore iii\|2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol\|2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol\|CCRIS 9205\|(deaminohydroxy) toremifene\|UNII-B0P231I
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, MODULATOR
Mechanism of action	Estrogen receptor modulator
Product Description	Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

Product Properties

ALogP	6.5

Associated Targets

ESR1 Tclin Estrogen receptor 0 Activities

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR2 Tclin Estrogen receptor beta 0 Activities

Discover Target: ESR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol
INCHI	InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
InChi Key	LUMKNAVTFCDUIE-VHXPQNKSSA-N
Canonical SMILES	C1=CC=C(C=C1)C(=C(C2=CC=CC=C2)C3=CC=C(C=C3)OCCO)CCCl
Isomeric SMILES	C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C3=CC=C(C=C3)OCCO)/CCCl
WGK Germany	3
PubChem CID	3036505
Molecular Weight	378.9
Reaxy-Rn	10283864

Database links

ChEMBL Ligand	CHEMBL2105395
PubChem CID	3036505
Wikipedia	Ospemifene
CAS Registry No.	128607-22-7
DrugBank Ligand	DB04938
DrugCentral Ligand	4749

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
I2219106	Certificate of Analysis	Aug 11, 2022	O159905
I2219108	Certificate of Analysis	Aug 11, 2022	O159905
I2219332	Certificate of Analysis	Aug 11, 2022	O159905
F2214257	Certificate of Analysis	Oct 12, 2021	O159905

Chemical and Physical Properties

Solubility	Chloroform (Slightly), Methanol (Slightly)
Melt Point(°C)	115-117°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H411:Toxic to aquatic life with long lasting effects H318:Causes serious eye damage H302+H312:Harmful if swallowed or in contact with skin
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312+P330:IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
WGK Germany	3
Reaxy-Rn	10283864

References

1. Rutanen EM, Heikkinen J, Halonen K, Komi J, Lammintausta R, Ylikorkala O. (2003) Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial.. Menopause, 10 (5): (433-9). [PMID:14501605]
2. Unkila M, Kari S, Yatkin E, Lammintausta R. (2013) Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause.. J Steroid Biochem Mol Biol, 138 (3): (107-15). [PMID:23665515]
3. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.. Biochim Biophys Acta, 1812 (8): (982-94). [PMID:21193033]

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