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O101699-1g

In stock

$118.90

O101699-5g

In stock

$325.90

O101699-10g

10g

Available within 8-12 weeks(?)

$586.90

O101699-25g

25g

Available within 8-12 weeks(?)

$1,320.90

Basic Description

Synonyms	Osthole \| Osthol \| 484-12-8 \| Ostol \| Ostole \| 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one \| 7-Methoxy-8-isopentenylcoumarin \| 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one \| 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)- \| 8-(3-Methyl-2-butenyl)herniari
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Bioactive coumarin. Anti-inflammatory and antitumor activity. Phosphoinositide inhibitor and calcium channel blocker (IC 50 = 4 μM). Suppresses NFκB activity to induce cell-cycle arrest and apoptosis in cancer cells.
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (1 Activities)

Discover Target: TRPV3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

Discover Target: ALOX5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

Discover Target: GBA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

Discover Target: CYP1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)

Discover Target: GAPDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BACE1 Tchem Beta-secretase 1 (15641 Activities)

Discover Target: BACE1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

COLO 205 (50209 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

T47D (39041 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A-431 (6446 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KB (17409 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL (112 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

XPO1 Tclin Exportin-1 (375 Activities)

Discover Target: XPO1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 (11476 Activities)

Discover Target: RAPGEF4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Salmonella typhimurium (15756 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania major (2877 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Botrytis cinerea (4183 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A10 (235 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MM46 (1 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388 (20296 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

V79 (1637 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

norA Quinolone resistance protein norA (2171 Activities)

Discover Target: norA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rhizoctonia solani (2251 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PA Polymerase acidic protein (806 Activities)

Discover Target: PA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)

Discover Target: Gabrg2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Colletotrichum camelliae (51 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bactrocera oleae (43 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

mdeA Fluoroquinolone resistance protein (28 Activities)

Discover Target: mdeA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
INCHI	InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
InChi Key	MBRLOUHOWLUMFF-UHFFFAOYSA-N
Canonical SMILES	CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
Isomeric SMILES	CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
WGK Germany	1
RTECS	GN7700000
Alternate CAS	484-12-8
PubChem CID	10228
NSC Number	31868
MeSH Entry Terms	7-methoxy-8-(3-methylpent-2-enyl)coumarin;osthol;osthole
Molecular Weight	244.29
Reaxy-Rn	1288399

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
D2422168	Certificate of Analysis	Apr 27, 2024	O101699
H2222039	Certificate of Analysis	Dec 28, 2023	O101699
H2222040	Certificate of Analysis	Dec 28, 2023	O101699
H2222041	Certificate of Analysis	Dec 28, 2023	O101699

Chemical and Physical Properties

Solubility	Insoluble in water; Very soluble in Methanol; Soluble in Ethanol
Boil Point(°C)	145～150°C
Melt Point(°C)	83-84°C

Safety and Hazards(GHS)

WGK Germany	1
RTECS	GN7700000
Reaxy-Rn	1288399
Merck Index	6895

Citations of This Product

1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. (2024) Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 198 (105749). [PMID:38225092]
2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao. (2023) Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice. STRAHLENTHERAPIE UND ONKOLOGIE, (1-9). [PMID:37963994]
3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. (2023) Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 196 (24): (105623). [PMID:37945232]
4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730]
5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770]
6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo. (2022) Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15737–15746). [PMID:36508570]
7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin. (2023) Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (4): (683-692). [PMID:36445387]
8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang. (2022) Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin. Frontiers in Chemistry, 10 [PMID:35464201]
9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie. (2021) DCLK1 might be a therapeutic target of osthole against cervical cancer. PHARMAZIE, 76 (10): (503-506). [PMID:34620279]

References

1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. (2024) Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 198 (105749). [PMID:38225092]
2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao. (2023) Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice. STRAHLENTHERAPIE UND ONKOLOGIE, (1-9). [PMID:37963994]
3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. (2023) Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 196 (24): (105623). [PMID:37945232]
4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730]
5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770]
6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo. (2022) Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15737–15746). [PMID:36508570]
7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin. (2023) Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (4): (683-692). [PMID:36445387]
8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang. (2022) Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin. Frontiers in Chemistry, 10 [PMID:35464201]
9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie. (2021) DCLK1 might be a therapeutic target of osthole against cervical cancer. PHARMAZIE, 76 (10): (503-506). [PMID:34620279]

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Osthole - 99%, high purity , CAS No.484-12-8