Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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O101699-1g | 1g | In stock | $118.90 | |
O101699-5g | 5g | In stock | $325.90 | |
O101699-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $586.90 | |
O101699-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,320.90 |
Bioactive coumarin. Anti-inflammatory and antitumor activity.
Synonyms | KBioSS_002022 | NSC 31868 | SDCCGMLS-0066780.P001 | 7-methoxy-8-(3-methylpent-2-enyl)coumarin | A827530 | KBio3_002589 | Spectrum2_000723 | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)- | DivK1c_007042 | AMY40671 | BBL013019 | Osthole (Osthol) |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Bioactive coumarin. Anti-inflammatory and antitumor activity. Phosphoinositide inhibitor and calcium channel blocker (IC 50 = 4 μM). Suppresses NFκB activity to induce cell-cycle arrest and apoptosis in cancer cells. |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one |
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INCHI | InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3 |
InChi Key | MBRLOUHOWLUMFF-UHFFFAOYSA-N |
Canonical SMILES | CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C |
Isomeric SMILES | CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C |
WGK Germany | 1 |
RTECS | GN7700000 |
Alternate CAS | 484-12-8 |
PubChem CID | 10228 |
NSC Number | 31868 |
MeSH Entry Terms | 7-methoxy-8-(3-methylpent-2-enyl)coumarin;osthol;osthole |
Molecular Weight | 244.29 |
Reaxy-Rn | 1288399 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2422168 | Certificate of Analysis | Apr 27, 2024 | O101699 |
H2222039 | Certificate of Analysis | Dec 28, 2023 | O101699 |
H2222040 | Certificate of Analysis | Dec 28, 2023 | O101699 |
H2222041 | Certificate of Analysis | Dec 28, 2023 | O101699 |
Solubility | Insoluble in water; Very soluble in Methanol; Soluble in Ethanol |
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Boil Point(°C) | 145~150°C |
Melt Point(°C) | 83-84°C |
WGK Germany | 1 |
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RTECS | GN7700000 |
Reaxy-Rn | 1288399 |
Merck Index | 6895 |
1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. (2024) Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 198 (105749). [PMID:38225092] [10.1016/j.pestbp.2023.105749] |
2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao. (2023) Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice. STRAHLENTHERAPIE UND ONKOLOGIE, (1-9). [PMID:37963994] [10.1007/s00066-023-02173-8] |
3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. (2023) Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 196 (24): (105623). [PMID:37945232] [10.1016/j.pestbp.2023.105623] |
4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730] [10.1021/acsami.3c06996] |
5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] [10.1002/ps.7431] |
6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo. (2022) Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15737–15746). [PMID:36508570] [10.1021/acs.jafc.2c06558] |
7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin. (2023) Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (4): (683-692). [PMID:36445387] [10.1007/s00210-022-02347-8] |
8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang. (2022) Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin. Frontiers in Chemistry, 10 [PMID:35464201] [10.3389/fchem.2022.862777] |
9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie. (2021) DCLK1 might be a therapeutic target of osthole against cervical cancer. PHARMAZIE, 76 (10): (503-506). [PMID:34620279] [10.1691/ph.2021.1641] |
10. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu. (2021) Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice. Oxidative Medicine and Cellular Longevity, 2021 (3309944). [PMID:34527170] [10.1155/2021/3309944] |
11. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng. (2021) Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy. Oncology Letters, 22 (4): (1-9). [PMID:34429766] [10.3892/ol.2021.12987] |
12. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang. (2021) Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7. Journal of Oncology, 2021 (6610511). [PMID:33727922] [10.1155/2021/6610511] |
13. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu. (2020) Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation. EUROPEAN JOURNAL OF PHARMACOLOGY, 867 (172788). [PMID:31712058] [10.1016/j.ejphar.2019.172788] |
14. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang. (2019) Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 115 (108922). [PMID:31048190] [10.1016/j.biopha.2019.108922] |
15. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang. (2018) Osthole inhibits triple negative breast cancer cells by suppressing STAT3. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-11). [PMID:30577812] [10.1186/s13046-018-0992-z] |
16. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang. (2018) Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages. JOURNAL OF PHARMACOLOGICAL SCIENCES, 137 (290). [PMID:30098910] [10.1016/j.jphs.2018.07.007] |
17. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang. (2018) Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. MEDIATORS OF INFLAMMATION, 2018 (4934592). [PMID:30057486] [10.1155/2018/4934592] |
18. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming. (2018) Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. CELLULAR & MOLECULAR BIOLOGY LETTERS, 23 (1): (1-11). [PMID:29743895] [10.1186/s11658-018-0086-0] |
1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. (2024) Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 198 (105749). [PMID:38225092] [10.1016/j.pestbp.2023.105749] |
2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao. (2023) Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice. STRAHLENTHERAPIE UND ONKOLOGIE, (1-9). [PMID:37963994] [10.1007/s00066-023-02173-8] |
3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. (2023) Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 196 (24): (105623). [PMID:37945232] [10.1016/j.pestbp.2023.105623] |
4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730] [10.1021/acsami.3c06996] |
5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] [10.1002/ps.7431] |
6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo. (2022) Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15737–15746). [PMID:36508570] [10.1021/acs.jafc.2c06558] |
7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin. (2023) Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (4): (683-692). [PMID:36445387] [10.1007/s00210-022-02347-8] |
8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang. (2022) Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin. Frontiers in Chemistry, 10 [PMID:35464201] [10.3389/fchem.2022.862777] |
9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie. (2021) DCLK1 might be a therapeutic target of osthole against cervical cancer. PHARMAZIE, 76 (10): (503-506). [PMID:34620279] [10.1691/ph.2021.1641] |
10. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu. (2021) Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice. Oxidative Medicine and Cellular Longevity, 2021 (3309944). [PMID:34527170] [10.1155/2021/3309944] |
11. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng. (2021) Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy. Oncology Letters, 22 (4): (1-9). [PMID:34429766] [10.3892/ol.2021.12987] |
12. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang. (2021) Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7. Journal of Oncology, 2021 (6610511). [PMID:33727922] [10.1155/2021/6610511] |
13. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu. (2020) Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation. EUROPEAN JOURNAL OF PHARMACOLOGY, 867 (172788). [PMID:31712058] [10.1016/j.ejphar.2019.172788] |
14. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang. (2019) Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 115 (108922). [PMID:31048190] [10.1016/j.biopha.2019.108922] |
15. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang. (2018) Osthole inhibits triple negative breast cancer cells by suppressing STAT3. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-11). [PMID:30577812] [10.1186/s13046-018-0992-z] |
16. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang. (2018) Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages. JOURNAL OF PHARMACOLOGICAL SCIENCES, 137 (290). [PMID:30098910] [10.1016/j.jphs.2018.07.007] |
17. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang. (2018) Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. MEDIATORS OF INFLAMMATION, 2018 (4934592). [PMID:30057486] [10.1155/2018/4934592] |
18. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming. (2018) Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. CELLULAR & MOLECULAR BIOLOGY LETTERS, 23 (1): (1-11). [PMID:29743895] [10.1186/s11658-018-0086-0] |