Osthole - 99%, high purity , CAS No.484-12-8

Item Number
O101699
Grouped product items
SKUSizeAvailabilityPrice Qty
O101699-1g
1g
In stock
$118.90
O101699-5g
5g
In stock
$325.90
O101699-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$586.90
O101699-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,320.90

Bioactive coumarin. Anti-inflammatory and antitumor activity.

Basic Description

SynonymsKBioSS_002022 | NSC 31868 | SDCCGMLS-0066780.P001 | 7-methoxy-8-(3-methylpent-2-enyl)coumarin | A827530 | KBio3_002589 | Spectrum2_000723 | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)- | DivK1c_007042 | AMY40671 | BBL013019 | Osthole (Osthol)
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsBioactive coumarin. Anti-inflammatory and antitumor activity. Phosphoinositide inhibitor and calcium channel blocker (IC 50 = 4 μM). Suppresses NFκB activity to induce cell-cycle arrest and apoptosis in cancer cells.
Storage TempRoom temperature
Shipped InNormal
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-431 (6446 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
XPO1 Tclin Exportin-1 (375 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 (11476 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania major (2877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Botrytis cinerea (4183 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A10 (235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MM46 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
V79 (1637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
norA Quinolone resistance protein norA (2171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rhizoctonia solani (2251 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PA Polymerase acidic protein (806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Colletotrichum camelliae (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bactrocera oleae (43 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
mdeA Fluoroquinolone resistance protein (28 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
INCHI InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
InChi Key MBRLOUHOWLUMFF-UHFFFAOYSA-N
Canonical SMILES CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
Isomeric SMILES CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
WGK Germany 1
RTECS GN7700000
Alternate CAS 484-12-8
PubChem CID 10228
NSC Number 31868
MeSH Entry Terms 7-methoxy-8-(3-methylpent-2-enyl)coumarin;osthol;osthole
Molecular Weight 244.29
Reaxy-Rn 1288399

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
D2422168Certificate of AnalysisApr 27, 2024 O101699
H2222039Certificate of AnalysisDec 28, 2023 O101699
H2222040Certificate of AnalysisDec 28, 2023 O101699
H2222041Certificate of AnalysisDec 28, 2023 O101699

Chemical and Physical Properties

SolubilityInsoluble in water; Very soluble in Methanol; Soluble in Ethanol
Boil Point(°C)145~150°C
Melt Point(°C)83-84°C

Safety and Hazards(GHS)

WGK Germany 1
RTECS GN7700000
Reaxy-Rn 1288399
Merck Index 6895

Related Documents

Citations of This Product

1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao.  (2024)  Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  198  (105749).  [PMID:38225092] [10.1016/j.pestbp.2023.105749]
2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao.  (2023)  Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice.  STRAHLENTHERAPIE UND ONKOLOGIE,    (1-9).  [PMID:37963994] [10.1007/s00066-023-02173-8]
3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li.  (2023)  Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  196  (24): (105623).  [PMID:37945232] [10.1016/j.pestbp.2023.105623]
4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu.  (2023)  Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds.  ACS Applied Materials & Interfaces,  15  (35): (41287–41298).  [PMID:37632730] [10.1021/acsami.3c06996]
5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long.  (2023)  Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms.  PEST MANAGEMENT SCIENCE,      [PMID:36864770] [10.1002/ps.7431]
6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo.  (2022)  Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (50): (15737–15746).  [PMID:36508570] [10.1021/acs.jafc.2c06558]
7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin.  (2023)  Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,  396  (4): (683-692).  [PMID:36445387] [10.1007/s00210-022-02347-8]
8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang.  (2022)  Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin.  Frontiers in Chemistry,  10    [PMID:35464201] [10.3389/fchem.2022.862777]
9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie.  (2021)  DCLK1 might be a therapeutic target of osthole against cervical cancer.  PHARMAZIE,  76  (10): (503-506).  [PMID:34620279] [10.1691/ph.2021.1641]
10. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu.  (2021)  Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.  Oxidative Medicine and Cellular Longevity,  2021  (3309944).  [PMID:34527170] [10.1155/2021/3309944]
11. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng.  (2021)  Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy.  Oncology Letters,  22  (4): (1-9).  [PMID:34429766] [10.3892/ol.2021.12987]
12. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang.  (2021)  Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7.  Journal of Oncology,  2021  (6610511).  [PMID:33727922] [10.1155/2021/6610511]
13. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu.  (2020)  Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation.  EUROPEAN JOURNAL OF PHARMACOLOGY,  867  (172788).  [PMID:31712058] [10.1016/j.ejphar.2019.172788]
14. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang.  (2019)  Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway.  BIOMEDICINE & PHARMACOTHERAPY,  115  (108922).  [PMID:31048190] [10.1016/j.biopha.2019.108922]
15. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang.  (2018)  Osthole inhibits triple negative breast cancer cells by suppressing STAT3.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-11).  [PMID:30577812] [10.1186/s13046-018-0992-z]
16. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang.  (2018)  Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages.  JOURNAL OF PHARMACOLOGICAL SCIENCES,  137  (290).  [PMID:30098910] [10.1016/j.jphs.2018.07.007]
17. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang.  (2018)  Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation.  MEDIATORS OF INFLAMMATION,  2018  (4934592).  [PMID:30057486] [10.1155/2018/4934592]
18. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming.  (2018)  Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  23  (1): (1-11).  [PMID:29743895] [10.1186/s11658-018-0086-0]

References

1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao.  (2024)  Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  198  (105749).  [PMID:38225092] [10.1016/j.pestbp.2023.105749]
2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao.  (2023)  Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice.  STRAHLENTHERAPIE UND ONKOLOGIE,    (1-9).  [PMID:37963994] [10.1007/s00066-023-02173-8]
3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li.  (2023)  Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  196  (24): (105623).  [PMID:37945232] [10.1016/j.pestbp.2023.105623]
4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu.  (2023)  Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds.  ACS Applied Materials & Interfaces,  15  (35): (41287–41298).  [PMID:37632730] [10.1021/acsami.3c06996]
5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long.  (2023)  Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms.  PEST MANAGEMENT SCIENCE,      [PMID:36864770] [10.1002/ps.7431]
6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo.  (2022)  Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (50): (15737–15746).  [PMID:36508570] [10.1021/acs.jafc.2c06558]
7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin.  (2023)  Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,  396  (4): (683-692).  [PMID:36445387] [10.1007/s00210-022-02347-8]
8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang.  (2022)  Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin.  Frontiers in Chemistry,  10    [PMID:35464201] [10.3389/fchem.2022.862777]
9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie.  (2021)  DCLK1 might be a therapeutic target of osthole against cervical cancer.  PHARMAZIE,  76  (10): (503-506).  [PMID:34620279] [10.1691/ph.2021.1641]
10. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu.  (2021)  Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.  Oxidative Medicine and Cellular Longevity,  2021  (3309944).  [PMID:34527170] [10.1155/2021/3309944]
11. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng.  (2021)  Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy.  Oncology Letters,  22  (4): (1-9).  [PMID:34429766] [10.3892/ol.2021.12987]
12. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang.  (2021)  Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7.  Journal of Oncology,  2021  (6610511).  [PMID:33727922] [10.1155/2021/6610511]
13. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu.  (2020)  Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation.  EUROPEAN JOURNAL OF PHARMACOLOGY,  867  (172788).  [PMID:31712058] [10.1016/j.ejphar.2019.172788]
14. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang.  (2019)  Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway.  BIOMEDICINE & PHARMACOTHERAPY,  115  (108922).  [PMID:31048190] [10.1016/j.biopha.2019.108922]
15. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang.  (2018)  Osthole inhibits triple negative breast cancer cells by suppressing STAT3.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-11).  [PMID:30577812] [10.1186/s13046-018-0992-z]
16. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang.  (2018)  Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages.  JOURNAL OF PHARMACOLOGICAL SCIENCES,  137  (290).  [PMID:30098910] [10.1016/j.jphs.2018.07.007]
17. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang.  (2018)  Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation.  MEDIATORS OF INFLAMMATION,  2018  (4934592).  [PMID:30057486] [10.1155/2018/4934592]
18. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming.  (2018)  Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  23  (1): (1-11).  [PMID:29743895] [10.1186/s11658-018-0086-0]

Solution Calculators