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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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O412290-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
O412290-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $156.90 | |
O412290-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $205.90 | |
O412290-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,241.90 |
Specifications & Purity | Moligand™, ≥98% |
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Biochemical and Physiological Mechanisms | OSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through a |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of integrin linked kinase |
Product Description | Information OSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through apoptosis and autophagy. |
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IUPAC Name | N-methyl-3-[1-(4-piperazin-1-ylphenyl)-5-[4-[4-(trifluoromethyl)phenyl]phenyl]pyrazol-3-yl]propanamide |
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INCHI | InChI=1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39) |
InChi Key | GHBUPSVATJKTRR-UHFFFAOYSA-N |
Canonical SMILES | CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5 |
Isomeric SMILES | CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5 |
PubChem CID | 51051074 |
MeSH Entry Terms | N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide;N-methyl-PPTBPP;OSU-T315 |
Molecular Weight | 533.59 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B2402420 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402421 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402452 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402453 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402454 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402455 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402456 | Certificate of Analysis | Dec 27, 2023 | O412290 |
B2402573 | Certificate of Analysis | Dec 27, 2023 | O412290 |
1. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. (2000) Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.. Proc Natl Acad Sci USA, 97 (7): (3207-12). [PMID:10716737] [10.1021/op500134e] |
2. Deng JT, Van Lierop JE, Sutherland C, Walsh MP. (2001) Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase.. J Biol Chem, 276 (19): (16365-73). [PMID:11278951] [10.1021/op500134e] |
3. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. (2001) Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.. J Biol Chem, 276 (29): (27462-9). [PMID:11313365] [10.1021/op500134e] |
4. Graff JR, Deddens JA, Konicek BW, Colligan BM, Hurst BM, Carter HW, Carter JH. (2001) Integrin-linked kinase expression increases with prostate tumor grade.. Clin Cancer Res, 7 (7): (1987-91). [PMID:11448915] [10.1021/op500134e] |
5. Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP. (2002) Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase.. Biochem J, 367 (Pt 2): (517-24). [PMID:12144526] [10.1021/op500134e] |
6. Ito R, Oue N, Zhu X, Yoshida K, Nakayama H, Yokozaki H, Yasui W. (2003) Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma.. Virchows Arch, 442 (2): (118-23). [PMID:12596061] [10.1021/op500134e] |
7. Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S. (2003) Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.. J Biol Chem, 278 (25): (22374-8). [PMID:12686550] [10.1021/op500134e] |
8. Ahmed N, Riley C, Oliva K, Stutt E, Rice GE, Quinn MA. (2003) Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid.. J Pathol, 201 (2): (229-37). [PMID:14517840] [10.1021/op500134e] |
9. Bravou V, Klironomos G, Papadaki E, Taraviras S, Varakis J. (2006) ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway.. J Pathol, 208 (1): (91-9). [PMID:16278819] [10.1021/op500134e] |
10. Schaeffer DF, Assi K, Chan K, Buczkowski AK, Chung SW, Scudamore CH, Weiss A, Salh B, Owen DA. (2010) Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma.. Virchows Arch, 456 (3): (261-8). [PMID:20091050] [10.1021/op500134e] |
11. Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S et al.. (2010) Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.. Oncogene, 29 (23): (3374-85). [PMID:20305688] [10.1021/op500134e] |
12. Chan J, Ko FC, Yeung YS, Ng IO, Yam JW. (2011) Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma.. PLoS ONE, 6 (2): (e16984). [PMID:21347395] [10.1021/op500134e] |
13. Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. (2011) Identification and characterization of a novel integrin-linked kinase inhibitor.. J Med Chem, 54 (18): (6364-74). [PMID:21823616] [10.1021/op500134e] |
14. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. (1998) Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.. Proc Natl Acad Sci USA, 95 (19): (11211-6). [PMID:9736715] [10.1021/op500134e] |