OSU-T315 analog - 98%, high purity , CAS No.1333146-24-9, Inhibitor of integrin linked kinase

Item Number
O412290
Grouped product items
SKUSizeAvailabilityPrice Qty
O412290-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
O412290-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$156.90
O412290-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$205.90
O412290-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,241.90

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsOSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through a
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of integrin linked kinase
Product Description

Information

OSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through apoptosis and autophagy.

Associated Targets(Human)

ILK Tchem Integrin-linked protein kinase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin Stem cell growth factor receptor (10667 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MET Tclin Hepatocyte growth factor receptor (10718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCA Tchem Protein kinase C alpha (5923 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ZAP70 Tchem Tyrosine-protein kinase ZAP-70 (2189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FLT3 Tclin Tyrosine-protein kinase receptor FLT3 (13481 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDK1 Tchem Pyruvate dehydrogenase kinase isoform 1 (2021 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KB1 Tchem Ribosomal protein S6 kinase 1 (4456 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PrEC (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-BR-3 (5175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMEC (560 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ILK Tchem Serine/threonine-protein kinase ILK-1 (603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ROS1 Tclin Proto-oncogene tyrosine-protein kinase ROS (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RICTOR Tbio Rapamycin-insensitive companion of mTOR (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK5 Tchem Cyclin-dependent kinase 5/CDK5 activator 1 (3697 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK1 Tchem Cyclin-dependent kinase 1/cyclin B1 (1887 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-methyl-3-[1-(4-piperazin-1-ylphenyl)-5-[4-[4-(trifluoromethyl)phenyl]phenyl]pyrazol-3-yl]propanamide
INCHI InChI=1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39)
InChi Key GHBUPSVATJKTRR-UHFFFAOYSA-N
Canonical SMILES CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5
Isomeric SMILES CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5
PubChem CID 51051074
MeSH Entry Terms N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide;N-methyl-PPTBPP;OSU-T315
Molecular Weight 533.59

Certificates

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8 results found

Lot NumberCertificate TypeDateItem
B2402420Certificate of AnalysisDec 27, 2023 O412290
B2402421Certificate of AnalysisDec 27, 2023 O412290
B2402452Certificate of AnalysisDec 27, 2023 O412290
B2402453Certificate of AnalysisDec 27, 2023 O412290
B2402454Certificate of AnalysisDec 27, 2023 O412290
B2402455Certificate of AnalysisDec 27, 2023 O412290
B2402456Certificate of AnalysisDec 27, 2023 O412290
B2402573Certificate of AnalysisDec 27, 2023 O412290

Related Documents

References

1. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S.  (2000)  Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells..  Proc Natl Acad Sci USA,  97  (7): (3207-12).  [PMID:10716737] [10.1021/op500134e]
2. Deng JT, Van Lierop JE, Sutherland C, Walsh MP.  (2001)  Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase..  J Biol Chem,  276  (19): (16365-73).  [PMID:11278951] [10.1021/op500134e]
3. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S.  (2001)  Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343..  J Biol Chem,  276  (29): (27462-9).  [PMID:11313365] [10.1021/op500134e]
4. Graff JR, Deddens JA, Konicek BW, Colligan BM, Hurst BM, Carter HW, Carter JH.  (2001)  Integrin-linked kinase expression increases with prostate tumor grade..  Clin Cancer Res,  (7): (1987-91).  [PMID:11448915] [10.1021/op500134e]
5. Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP.  (2002)  Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase..  Biochem J,  367  (Pt 2): (517-24).  [PMID:12144526] [10.1021/op500134e]
6. Ito R, Oue N, Zhu X, Yoshida K, Nakayama H, Yokozaki H, Yasui W.  (2003)  Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma..  Virchows Arch,  442  (2): (118-23).  [PMID:12596061] [10.1021/op500134e]
7. Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S.  (2003)  Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation..  J Biol Chem,  278  (25): (22374-8).  [PMID:12686550] [10.1021/op500134e]
8. Ahmed N, Riley C, Oliva K, Stutt E, Rice GE, Quinn MA.  (2003)  Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid..  J Pathol,  201  (2): (229-37).  [PMID:14517840] [10.1021/op500134e]
9. Bravou V, Klironomos G, Papadaki E, Taraviras S, Varakis J.  (2006)  ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway..  J Pathol,  208  (1): (91-9).  [PMID:16278819] [10.1021/op500134e]
10. Schaeffer DF, Assi K, Chan K, Buczkowski AK, Chung SW, Scudamore CH, Weiss A, Salh B, Owen DA.  (2010)  Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma..  Virchows Arch,  456  (3): (261-8).  [PMID:20091050] [10.1021/op500134e]
11. Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S et al..  (2010)  Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer..  Oncogene,  29  (23): (3374-85).  [PMID:20305688] [10.1021/op500134e]
12. Chan J, Ko FC, Yeung YS, Ng IO, Yam JW.  (2011)  Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma..  PLoS ONE,  (2): (e16984).  [PMID:21347395] [10.1021/op500134e]
13. Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS.  (2011)  Identification and characterization of a novel integrin-linked kinase inhibitor..  J Med Chem,  54  (18): (6364-74).  [PMID:21823616] [10.1021/op500134e]
14. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S.  (1998)  Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase..  Proc Natl Acad Sci USA,  95  (19): (11211-6).  [PMID:9736715] [10.1021/op500134e]

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