Basic Description

Synonyms	P22077 \| HY-13865 \| Z1614727651 \| 1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone \| 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanon \| FT-0707469 \| LGTLXDJOAJDFLR-UHFFFAOYSA- \| AC-32695 \| SW219709-1 \| A899043 \| C71981 \| EX-A144
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective\xa0USP7 (IC 50 = 8\xa0μM)\xa0inhibitor. Active against closely related USP47. Selective versus SENP2c0re (IC 50 >50\xa0μM) and DENI (IC 50 >50\xa0μM). Destabilizes Claspin. Inhibits neuroblastoma growth by inducing p53-mediated apoptosis.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.

Associated Targets(Human)

CASP3 Tchem Caspase-3 (3632 Activities)

Discover Target: CASP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)

Discover Target: USP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP47 Tchem Ubiquitin carboxyl-terminal hydrolase 47 (99 Activities)

Discover Target: USP47

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-[5-(2,4-difluorophenyl)sulfanyl-4-nitrothiophen-2-yl]ethanone
INCHI	InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3
InChi Key	RMAMGGNACJHXHO-UHFFFAOYSA-N
Canonical SMILES	CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-]
Isomeric SMILES	CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-]
PubChem CID	46931953
UN Number	3077
Packing Group	III
Molecular Weight	315.32

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
L2405191	Certificate of Analysis	Dec 11, 2024	P275353
I2202899	Certificate of Analysis	Jun 13, 2023	P275353
I2202802	Certificate of Analysis	Jun 13, 2023	P275353
I2202809	Certificate of Analysis	Jun 13, 2023	P275353

Chemical and Physical Properties

Solubility	Soluble in DMSO to 75 mM

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray.
Class	9

References

1. Li N et al.. (2021) Upregulation of deubiquitinase USP7 by transcription factor FOXO6 promotes EC progression via targeting the JMJD3/CLU axis.. Mol Ther Oncolytics, 20 (583-595). [PMID:33768140]

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SKU	Size	Availability	Price
P275353-10mg	10mg	In stock	$100.90
P275353-50mg	50mg	In stock	$384.90
P275353-250mg	250mg	In stock	$1,732.90

P 22077 - ≥98%, high purity , CAS No.1247819-59-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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