PMSF Solution - 100mM in ethanol, high purity , CAS No.329-98-6

9 Citations
  • 100mM in ethanol
Item Number
P301906
Grouped product items
SKUSizeAvailabilityPrice Qty
P301906-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$35.90
P301906-5×1ml
5×1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$161.90

Non-specific protease inhibitor

Basic Description

SynonymsPMSF | C06747 | P-4170 | PHENYLMETHYLSULFONYL-FLUORIDE | PMSF | HMS3656J16 | NCI60_041962 | EINECS 206-350-2 | alpha-TOLUENESULFONYL FLUORIDE | BDBM50171289 | BRN 2088311 | DTXSID6059819 | Phenylmethanesulfonyl fluoride, >=99.0% (T) | 3-11-00-00331 (Beils
Specifications & Purity100mM in ethanol
Biochemical and Physiological MechanismsAdministration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.Non-specific protease inhibitor; binds key active site serine residue in serine proteases, acety
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

ELANE Tclin Neutrophil elastase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CES1 Tchem Liver carboxylesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRTN3 Tchem Myeloblastin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FAAH Tchem Fatty-acid amide hydrolase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRSS1 Tclin Trypsin-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PARL Tchem Presenilins-associated rhomboid-like protein, mitochondrial (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MGLL Tchem Monoglyceride lipase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ELANE Tclin Leukocyte elastase (8173 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRTN3 Tchem Leukocyte proteinase 3 (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-4 (44535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-19 (46794 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-257 (46019 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC 2998 (41480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-92 (41141 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-268 (49410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGROV-1 (47897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LOX IMVI (44321 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-62 (47048 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-N (28205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Malme-3M (44254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Trypsin (394 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Faah Anandamide amidohydrolase (3907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Parl Presenilins-associated rhomboid-like protein, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
glpG Rhomboid protease GlpG (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name phenylmethanesulfonyl fluoride
INCHI InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChi Key YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)CS(=O)(=O)F
Isomeric SMILES C1=CC=C(C=C1)CS(=O)(=O)F
WGK Germany 3
RTECS XT8040000
PubChem CID 4784
UN Number 2928
Molecular Weight 174.19
Beilstein 2088311
Reaxy-Rn 2088311

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
D2208009Certificate of AnalysisJul 13, 2022 P301906

Chemical and Physical Properties

SolubilitySolubility in water: Hydrolysis Solubility in other solvents: Soluble in xylene and petroleum ether
SensitivityMoisture Sensitive
Boil Point(°C)85°C/0.3mmHg
Melt Point(°C)92-95°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS05
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H314:Causes severe skin burns and eye damage

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P310:Immediately call a POISON CENTER or doctor/physician.

WGK Germany 3
RTECS XT8040000
Reaxy-Rn 2088311
Merck Index 7542

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2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian.  (2023)  Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage.  ACS Applied Materials & Interfaces,  15  (28): (33903–33915).  [PMID:37410709]
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun.  (2023)  The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats.  Experimental and Therapeutic Medicine,  25  (5): (1-7).  [PMID:37114173]
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen.  (2023)  Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications.  CURRENT PHARMACEUTICAL DESIGN,  29  (4): ( 283–294).  [PMID:36722481]
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu.  (2023)  Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase.  BIOMACROMOLECULES,  24  (2): (921–928).  [PMID:36644840]
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao.  (2023)  An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals.  BIOSENSORS & BIOELECTRONICS,  222  (115013).  [PMID:36529054]
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge.  (2023)  Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress.  Journal of Environmental Sciences,  131  (141).  [PMID:37225375]
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin.  (2022)  Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries).  JOURNAL OF THERMAL BIOLOGY,  109  (103333).  [PMID:36195394]
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing.  (2022)  Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells.  Evidence-based Complementary and Alternative Medicine,  2022  (7008907).  [PMID:35873638]

References

1. Ni Z et al..  (2015)  AU4S: a novel synthetic peptide to measure the activity of ATG4 in living cells..  Autophagy,  11  (2): (403-15).  [PMID:25831015]
2. Abd-Ella EM et al..  (2020)  Dehydroepiandrosterone protects against acetaminophen-induced liver damage in rats by upregulation of Bcl-2 and activation of sirt signalling..  J Physiol Pharmacol,  71  (6):   [PMID:33727425]
3. Song Y et al..  (2016)  Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model..  PLoS One,  11  (10): (e0163165).  [PMID:27711221]
4. Alshehri AS.  (2021)  Kaempferol attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by a hypoglycaemic effect and concomitant activation of the Nrf-2/Ho-1/antioxidants axis..  Arch Physiol Biochem,    (1-14).  [PMID:33625930]
5. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao.  (2023)  Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.  BMC IMMUNOLOGY,  24  (1): (1-12).  [PMID:38066482]
6. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian.  (2023)  Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage.  ACS Applied Materials & Interfaces,  15  (28): (33903–33915).  [PMID:37410709]
7. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun.  (2023)  The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats.  Experimental and Therapeutic Medicine,  25  (5): (1-7).  [PMID:37114173]
8. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen.  (2023)  Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications.  CURRENT PHARMACEUTICAL DESIGN,  29  (4): ( 283–294).  [PMID:36722481]
9. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu.  (2023)  Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase.  BIOMACROMOLECULES,  24  (2): (921–928).  [PMID:36644840]
10. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao.  (2023)  An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals.  BIOSENSORS & BIOELECTRONICS,  222  (115013).  [PMID:36529054]
11. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge.  (2023)  Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress.  Journal of Environmental Sciences,  131  (141).  [PMID:37225375]
12. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin.  (2022)  Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries).  JOURNAL OF THERMAL BIOLOGY,  109  (103333).  [PMID:36195394]
13. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing.  (2022)  Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells.  Evidence-based Complementary and Alternative Medicine,  2022  (7008907).  [PMID:35873638]

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