p38α inhibitor 2 - 10mM in DMSO, high purity , CAS No.1095003-80-7(DMSO)

Item Number

P654871

Grouped product items
SKU	Size	Availability	Price	Qty
P654871-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$366.90

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Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC 50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC 50 =27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets IC50& Target:p38α MAPK 9.6 (pIC 50 )

Associated Targets(Human)

RPS6KA5 Tchem Ribosomal protein S6 kinase alpha-5 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPKAPK2 Tchem MAP kinase-activated protein kinase 2 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Canonical SMILES

CC1=C(C=C(C=C1)C(=O)NC2CC2)N3C=CN=C(C3=O)NC(C)(C)C4=CC=CC=C4OCCNC

Molecular Weight

475.58

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Basic Description