Potent, selective and cell-permeable USP-7 inhibitor (EC 50 = 4.2 μM). Induces apoptosis in cancer cells in vitro . Antiangiogenic and antitumor agent. Active in vitro and in vivo .
P5091 plays an important role in ovarian cancer, as it can prevent the gr
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store under desiccating conditions. The product can be stored for up to 12 months.
Application
P5091 has been used:
as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow−resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)
A2310114