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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P275159-10mg | 10mg | In stock | $103.90 | |
P275159-50mg | 50mg | In stock | $416.90 |
Pro-neurogenic and neuroprotective compound
Synonyms | P7C3 | 301353-96-8 | 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol | 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol | MFCD00572918 | 3,6-Dibromo-alpha-[(phenylamino)methyl]-9H-carbazole-9-etha |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Pro-neurogenic and neuroprotective compound. Blocks apoptosis of newborn neurons of the dentate gyrus. Also protects mature neurons. Enhances neurogenesis and additionally improves cognitive behaviour. Blood-brain barrier permeable. Active in vivo . |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Application: P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury. |
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IUPAC Name | 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol |
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INCHI | InChI=1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2 |
InChi Key | FZHHRERIIVOATI-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O |
Isomeric SMILES | C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O |
PubChem CID | 2836187 |
Molecular Weight | 474.19 |
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Solubility | Soluble in DMSO to 100 mM |
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Sensitivity | Light sensitive |
Pictogram(s) | GHS06, GHS05 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H318:Causes serious eye damage |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. |