Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P288123-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $79.90 | |
P288123-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $249.90 | |
P288123-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $399.90 | |
P288123-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $657.90 | |
P288123-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $936.90 |
RXR antagonist
Specifications & Purity | Moligand™, ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | RXR antagonist (pA2= 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of Retinoid X receptor-α |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[(3-hexoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-methylamino]pyrimidine-5-carboxylic acid |
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INCHI | InChI=1S/C26H37N3O3/c1-7-8-9-10-13-32-22-15-20-19(25(2,3)11-12-26(20,4)5)14-21(22)29(6)24-27-16-18(17-28-24)23(30)31/h14-17H,7-13H2,1-6H3,(H,30,31) |
InChi Key | JJUUTJCZMGZJDZ-UHFFFAOYSA-N |
Canonical SMILES | CCCCCCOC1=C(C=C2C(=C1)C(CCC2(C)C)(C)C)N(C)C3=NC=C(C=N3)C(=O)O |
Isomeric SMILES | CCCCCCOC1=C(C=C2C(=C1)C(CCC2(C)C)(C)C)N(C)C3=NC=C(C=N3)C(=O)O |
PubChem CID | 9803242 |
Molecular Weight | 439.59 |
PubChem CID | 9803242 |
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ChEMBL Ligand | CHEMBL115097 |
BindingDB Ligand | 50382930 |
CAS Registry No. | 457657-34-0 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2422195 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422196 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422197 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422198 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422199 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422200 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422201 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422202 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422203 | Certificate of Analysis | Apr 15, 2024 | P288123 |
G2422204 | Certificate of Analysis | Apr 15, 2024 | P288123 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 43.96, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 4.4, Max Conc. mM: 10 |
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1. Takahashi B, Ohta K, Kawachi E, Fukasawa H, Hashimoto Y, Kagechika H. (2002) Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.. J Med Chem, 45 (16): (3327-30). [PMID:12139443] [10.1021/op500134e] |
2. Nakayama M, Yamada S, Ohsawa F, Ohta Y, Kawata K, Makishima M, Kakuta H. (2011) Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB.. ACS Med Chem Lett, 2 (12): (896-900). [PMID:24900278] [10.1021/op500134e] |