Basic Description

Synonyms	MS-25238 \| Z2734706286 \| CS-0120903 \| AT33706 \| AKOS021652775 \| PA-8 \| HMS3431D05 \| HY-133529 \| SCHEMBL23547113 \| EN300-1721635 \| AKOS000619543 \| DTXSID601113935 \| AKOS040758424 \| CCG-123141 \| 2-amino-5-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]-3H,4H,5H,6H,
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	PAC1receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levelsin vitro(IC50= 2 nM) and PACAP-induced aversive responses and mechanical allodynia f
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product description PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM.

Associated Targets(Human)

ADCYAP1R1 Tchem Pituitary adenylate cyclase-activating polypeptide type I receptor (345 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pubchem Sid	488202956
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202956
IUPAC Name	2-amino-5-(3-methoxy-4-prop-2-enoxyphenyl)-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-dione
INCHI	InChI=1S/C17H18N4O4/c1-3-6-25-11-5-4-9(7-12(11)24-2)10-8-13(22)19-15-14(10)16(23)21-17(18)20-15/h3-5,7,10H,1,6,8H2,2H3,(H4,18,19,20,21,22,23)
InChi Key	DCSWTWUTSKSXOV-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=CC(=C1)C2CC(=O)NC3=C2C(=O)NC(=N3)N)OCC=C
Isomeric SMILES	COC1=C(C=CC(=C1)C2CC(=O)NC3=C2C(=O)NC(=N3)N)OCC=C
PubChem CID	135511602
Molecular Weight	342.35

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
D23181060	Certificate of Analysis	Mar 14, 2023	P286844
D23181071	Certificate of Analysis	Mar 14, 2023	P286844
D23181072	Certificate of Analysis	Mar 14, 2023	P286844
D23181076	Certificate of Analysis	Mar 14, 2023	P286844
D23181098	Certificate of Analysis	Mar 14, 2023	P286844
D23181112	Certificate of Analysis	Mar 14, 2023	P286844
D23181113	Certificate of Analysis	Mar 14, 2023	P286844
D23181257	Certificate of Analysis	Mar 14, 2023	P286844
D23181270	Certificate of Analysis	Mar 14, 2023	P286844
D23181331	Certificate of Analysis	Mar 14, 2023	P286844

Solubility	Solvent:DMSO, Max Conc. mg/mL: 17.12, Max Conc. mM: 50

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

SKU	Size	Availability	Price
P286844-5mg	5mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$103.90
P286844-10mg	10mg	In stock	$158.90
P286844-25mg	25mg	In stock	$356.90
P286844-50mg	50mg	In stock	$666.90
P286844-100mg	100mg	In stock	$1,200.90