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P106868-10mg

10mg

Available within 4-8 weeks(?)

$118.90

Basic Description

Synonyms	33069-62-4\|P88XT4IS4D\|Paclitaxel\|Taxol\|Taxol A\|Yewtaxan\|Genaxol\|Plaxicel\|Abraxane\|Ebetaxel\|Genetaxyl\|Capxol\|Cyclopax\|Genexol\|Intaxel\|Mitotax\|Paxene\|Onxol\|TaxAlbin\|OncoGel\|Pacliex\|Paxceed\|EmPAC\|Onxal\|Zisu\|Taxus stent\|Taxus Liberte\|ABI-007\|Padexol\|EndoTAG 1
Specifications & Purity	Moligand™, analytical standard, ≥99%
Biochemical and Physiological Mechanisms	Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroy
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	analytical standard, Moligand™
Action Type	AGONIST, INHIBITOR
Mechanism of action	Agonist of Pregnane X receptor;Agonist of TLR4;Inhibitor of tubulin beta class I
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Note: Some researchers have found solubility issues in PBS. The recommended procedure (from researcher feedback) for successful solubilisation is as follows: Solubilise 10 mg of ab120143 in 1.25 mL ethanol absolute, mix well, add 1.25mL Cremophor, homogenise. Store at -20°C and after 24 h, defreeze quickly and solubilise in PBS, no crystallisation observed. Please note, Abcam has not yet tested this method. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. An antineoplastic and apoptosis inducing agent

Product Properties

ALogP	2.5

Names and Identifiers

IUPAC Name	[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
INCHI	InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChi Key	RCINICONZNJXQF-MZXODVADSA-N
Canonical SMILES	CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Isomeric SMILES	CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
WGK Germany	3
RTECS	DA8340700
PubChem CID	36314
UN Number	2811
Packing Group	I
Molecular Weight	853.91
Beilstein	1420457

Database links

PubChem CID	36314
CAS Registry No.	33069-62-4
DrugBank Ligand	DB01229
BindingDB Ligand	50001839
ChEBI	CHEBI:45863
Wikipedia	Paclitaxel
ChEMBL Ligand	CHEMBL428647
NURSA Ligand	10.1621/ZJSTGVJ65V
RCSB PDB Ligand	TA1
PEP	paclitaxel
DrugCentral Ligand	2044

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
J2126748	Certificate of Analysis	Aug 16, 2023	P106868
B2327845	Certificate of Analysis	Mar 11, 2023	P106868
H2202414	Certificate of Analysis	Feb 09, 2023	P106868
D2123071	Certificate of Analysis	Jan 17, 2023	P106868

Chemical and Physical Properties

Specific Rotation[α]	-49 ° (C=1, MeOH)
Melt Point(°C)	213-216°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H413:May cause long lasting harmful effects to aquatic life H318:Causes serious eye damage H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
RTECS	DA8340700
Class	6.1
Merck Index	6982

References

1. Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M. (2000) Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol.. J Biol Chem, 275 (4): (2251-4). [PMID:10644670]
2. Lee ST et al.. (2011) Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells.. PLoS One, 6 (4): (e18915). [PMID:21541327]
3. Wala K et al.. (2022) Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma.. Molecules, 27 (9): [PMID:35566044]
4. Rose JC et al.. (2018) Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices.. Biomaterials, 163 (128-141). [PMID:29459322]
5. Dong P et al.. (2013) Induction of paclitaxel resistance by ERa mediated prohibitin mitochondrial-nuclear shuttling.. PLoS One, 8 (12): (e83519). [PMID:24376711]
6. Liu M et al.. (2021) Identification of a prognostic chemoresistance-related gene signature associated with immune microenvironment in breast cancer.. Bioengineered, 12 (8419-8434). [PMID:34661511]
7. Lai SL et al.. (2012) In vitro and in vivo anti-angiogenic activities of Panduratin A.. PLoS One, 7 (5): (e38103). [PMID:22666456]
8. Ferreira SA et al.. (2018) Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence.. Biomaterials, 176 (13-23). [PMID:29852376]
9. Samanta J et al.. (2020) Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway.. Cardiovasc Toxicol, 20 (3): (261-280). [PMID:31571030]
10. Yang Y et al.. (2016) Skp2 is associated with paclitaxel resistance in prostate cancer cells.. Oncol Rep, 36 (559-66). [PMID:27175797]
11. Tran LNK et al.. (2017) The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer.. Mol Cancer Ther, 16 (12): (2689-2700). [PMID:28802253]
12. Materazzi S et al.. (2012) TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism.. Pflugers Arch, 463 (4): (561-9). [PMID:22258694]

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Paclitaxel - analytical standard，≥99%, high purity , CAS No.33069-62-4, Agonist of Pregnane X receptor;Agonist of TLR4;Inhibitor of tubulin beta class I