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Paclitaxel - 99%, high purity , Tubulin inhibitor, CAS No.33069-62-4, Tubulin inhibitor

  • Moligand™
  • ≥99%
Item Number
P106869
Grouped product items
SKUSizeAvailabilityPrice Qty
P106869-10mg
10mg
In stock
$29.90
P106869-50mg
50mg
In stock
$122.90
P106869-250mg
250mg
In stock
$553.90
P106869-1g
1g
In stock
$1,992.90
P106869-5g
5g
In stock
$8,966.90

Promotes assembly and inhibits disassembly of microtubules

Basic Description

Synonyms33069-62-4|P88XT4IS4D|Paclitaxel|Taxol|Taxol A|Yewtaxan|Genaxol|Plaxicel|Abraxane|Ebetaxel|Genetaxyl|Capxol|Cyclopax|Genexol|Intaxel|Mitotax|Paxene|Onxol|TaxAlbin|OncoGel|Pacliex|Paxceed|EmPAC|Onxal|Zisu|Taxus stent|Taxus Liberte|ABI-007|Padexol|EndoTAG 1
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsAntitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionTubulin inhibitor
Product Description

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
An antineoplastic and apoptosis inducing agent

Product Properties

ALogP2.5

Names and Identifiers

Pubchem Sid488183273
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488183273
IUPAC Name [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
INCHI InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChi Key RCINICONZNJXQF-MZXODVADSA-N
Canonical SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Isomeric SMILES CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
WGK Germany 3
RTECS DA8340700
PubChem CID 36314
UN Number 2811
Packing Group I
Molecular Weight 853.91
Beilstein 1420457

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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22 results found

Lot NumberCertificate TypeDateItem
L2308301Certificate of AnalysisNov 22, 2023 P106869
L2308299Certificate of AnalysisNov 22, 2023 P106869
L2308298Certificate of AnalysisNov 22, 2023 P106869
L2308297Certificate of AnalysisNov 22, 2023 P106869
L1910090Certificate of AnalysisSep 08, 2023 P106869
B2327821Certificate of AnalysisNov 01, 2022 P106869
B2327997Certificate of AnalysisNov 01, 2022 P106869
B2327852Certificate of AnalysisNov 01, 2022 P106869
B2327850Certificate of AnalysisNov 01, 2022 P106869
B2327838Certificate of AnalysisNov 01, 2022 P106869
B2327837Certificate of AnalysisNov 01, 2022 P106869
B2327836Certificate of AnalysisNov 01, 2022 P106869
B2327835Certificate of AnalysisNov 01, 2022 P106869
B2327834Certificate of AnalysisNov 01, 2022 P106869
B2327820Certificate of AnalysisNov 01, 2022 P106869
G2424023Certificate of AnalysisJun 01, 2022 P106869
H2202442Certificate of AnalysisJun 01, 2022 P106869
H2202462Certificate of AnalysisJun 01, 2022 P106869
H2202463Certificate of AnalysisJun 01, 2022 P106869
H2202498Certificate of AnalysisJun 01, 2022 P106869
H2202499Certificate of AnalysisJun 01, 2022 P106869
C1809037Certificate of AnalysisJan 25, 2022 P106869

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Chemical and Physical Properties

SolubilitySolvent:ethanol, Max Conc. mg/mL: 21.35, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 85.39, Max Conc. mM: 100 with gentle warming
Specific Rotation[α]-49 ° (C=1, MeOH)
Melt Point(°C)213-216°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H335:May cause respiratory irritation

H341:Suspected of causing genetic defects

H413:May cause long lasting harmful effects to aquatic life

H318:Causes serious eye damage

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H340:May cause genetic defects

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P281:Use personal protective equipment as required.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3
RTECS DA8340700
Class 6.1
Merck Index 6982

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