Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P106869-10mg | 10mg | In stock | $29.90 | |
P106869-50mg | 50mg | In stock | $122.90 | |
P106869-250mg | 250mg | In stock | $553.90 | |
P106869-1g | 1g | In stock | $1,992.90 | |
P106869-5g | 5g | In stock | $8,966.90 |
Promotes assembly and inhibits disassembly of microtubules
Synonyms | NSC125973 | NSC-125973 | Onxal | ORAXOL COMPONENT PACLITAXEL | Pacliex | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Tubulin inhibitor |
Product Description | Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
ALogP | 2.5 |
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Pubchem Sid | 488183273 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183273 |
IUPAC Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
INCHI | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1 |
InChi Key | RCINICONZNJXQF-MZXODVADSA-N |
Canonical SMILES | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C |
Isomeric SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C |
WGK Germany | 3 |
RTECS | DA8340700 |
PubChem CID | 36314 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 853.91 |
Beilstein | 1420457 |
PubChem SID | 488183273 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2308301 | Certificate of Analysis | Nov 22, 2023 | P106869 |
L2308299 | Certificate of Analysis | Nov 22, 2023 | P106869 |
L2308298 | Certificate of Analysis | Nov 22, 2023 | P106869 |
L2308297 | Certificate of Analysis | Nov 22, 2023 | P106869 |
L1910090 | Certificate of Analysis | Sep 08, 2023 | P106869 |
B2327821 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327997 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327852 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327850 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327838 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327837 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327836 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327835 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327834 | Certificate of Analysis | Nov 01, 2022 | P106869 |
B2327820 | Certificate of Analysis | Nov 01, 2022 | P106869 |
G2424023 | Certificate of Analysis | Jun 01, 2022 | P106869 |
H2202442 | Certificate of Analysis | Jun 01, 2022 | P106869 |
H2202462 | Certificate of Analysis | Jun 01, 2022 | P106869 |
H2202463 | Certificate of Analysis | Jun 01, 2022 | P106869 |
H2202498 | Certificate of Analysis | Jun 01, 2022 | P106869 |
H2202499 | Certificate of Analysis | Jun 01, 2022 | P106869 |
C1809037 | Certificate of Analysis | Jan 25, 2022 | P106869 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 21.35, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 85.39, Max Conc. mM: 100 with gentle warming |
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Specific Rotation[α] | -49 ° (C=1, MeOH) |
Melt Point(°C) | 213-216°C |
Pictogram(s) | GHS08, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H413:May cause long lasting harmful effects to aquatic life H318:Causes serious eye damage H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |
RTECS | DA8340700 |
Class | 6.1 |
Merck Index | 6982 |
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46. Beibei Zhang, Rui Xue, Chunyang Sun. (2022) Rational design of ROS-responsive nanocarriers for targeted X-ray-induced photodynamic therapy and cascaded chemotherapy of intracranial glioblastoma. Nanoscale, 14 (13): (5054-5067). [PMID:35293920] |
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