PACMA 31 - 98%, high purity , CAS No.1401089-31-3

Item Number

P287528

• Synonyms: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycineethylester | MS-27651 | PACMA 31, >=98% (HPLC) | 1401089-31-3 | Ethyl 2-(2-(N-(2,4-dimethoxyphenyl)propiolamido)-2-(thiophen-2-yl)acetamido)acetate | SCHEMBL14788388 | CS-0018903 |
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
• Storage Temp: Room temperature
• Shipped In: Normal

Product Description

PACMA 31 is an irreversible, protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.