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PACMA 31 - 98%, high purity , CAS No.1401089-31-3

≥98%

CAS#: 1401089-31-3
Formula: C₂₁H₂₂N₂O₆S
Molecular Weight: 430.47
PubChem CID: 66555902

Item Number

P287528

Grouped product items
SKU	Size	Availability	Price
P287528-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$21.90
P287528-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$74.90
P287528-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$124.90
P287528-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$259.90
P287528-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$437.90
P287528-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$699.90

Irreversible protein disulfide isomerase (PDI) inhibitor

View related series

Cell Cycle/DNA Damage Metabolic Enzyme/Protease PDI

Basic Description

Synonyms	PACMA 31\|1401089-31-3\|CHEMBL4542919\|N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycineethylester\|Ethyl 2-(2-(N-(2,4-dimethoxyphenyl)propiolamido)-2-(thiophen-2-yl)acetamido)acetate\|N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
Storage Temp	Room temperature
Shipped In	Normal
Product Description	PACMA 31 is an irreversible, protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Associated Targets

EIF2S1 Tchem Eukaryotic translation initiation factor 2 subunit 1 0 Activities

Discover Target: EIF2S1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P4HB Tchem Protein disulfide-isomerase 0 Activities

Discover Target: P4HB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase 0 Activities

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	ethyl 2-[[2-(2,4-dimethoxy-N-prop-2-ynoylanilino)-2-thiophen-2-ylacetyl]amino]acetate
INCHI	InChI=1S/C21H22N2O6S/c1-5-18(24)23(15-10-9-14(27-3)12-16(15)28-4)20(17-8-7-11-30-17)21(26)22-13-19(25)29-6-2/h1,7-12,20H,6,13H2,2-4H3,(H,22,26)
InChi Key	AHOOZADJPNUFOQ-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)CNC(=O)C(C1=CC=CS1)N(C2=C(C=C(C=C2)OC)OC)C(=O)C#C
Isomeric SMILES	CCOC(=O)CNC(=O)C(C1=CC=CS1)N(C2=C(C=C(C=C2)OC)OC)C(=O)C#C
WGK Germany	3
PubChem CID	66555902
Molecular Weight	430.47

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
G2410490	Certificate of Analysis	Mar 22, 2024	P287528
G2410494	Certificate of Analysis	Mar 22, 2024	P287528
G2410495	Certificate of Analysis	Mar 22, 2024	P287528
G2410497	Certificate of Analysis	Mar 22, 2024	P287528
G2410500	Certificate of Analysis	Mar 22, 2024	P287528
G2410501	Certificate of Analysis	Mar 22, 2024	P287528
G2410504	Certificate of Analysis	Mar 22, 2024	P287528
G2410505	Certificate of Analysis	Mar 22, 2024	P287528
G2410506	Certificate of Analysis	Mar 22, 2024	P287528
G2410508	Certificate of Analysis	Mar 22, 2024	P287528
G2410511	Certificate of Analysis	Mar 22, 2024	P287528
G2410514	Certificate of Analysis	Mar 22, 2024	P287528

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RIDADR	UN28116.1/PGIII

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