Palmatine chloride - 98%, high purity , CAS No.10605-02-4

Item Number

P274975

• Synonyms: Palmatine chloride | 10605-02-4 | Palmatine hydrochloride | Palmatine (chloride) | Fibrauretin | 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride | ZJ6W8881Z8 | 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Protoberberine alkaloid. AChE inhibitor (IC 50 = 7 μM). Central monoamine modulator. Shows antioxidant effects. Decreases central catecholamine activity. Decreases dopamine and increases 5-HT concentration in the brain. Shows antiarrhythmic, analgesic and
• Source: Synthetic
• Storage Temp: Store at -20°C,Argon charged,Desiccated
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product description：

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.