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Pamoic acid - 97%, high purity , CAS No.130-85-8, Agonist of GPR35

  • Moligand™
  • ≥97%
Item Number
P106763
Grouped product items
SKUSizeAvailabilityPrice Qty
P106763-5g
5g
In stock
$9.90
P106763-25g
25g
In stock
$19.90
P106763-100g
100g
In stock
$68.90
P106763-250g
250g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$153.90
P106763-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$277.90
View related series
GPR35 Agonist

Basic Description

SynonymsPAMOIC ACID|130-85-8|Embonic acid|4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)|Pamosaeure|2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-|NSC30188|4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid|MFCD000040
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPamoic acid, also known as embonic acid, is the free acid form of pamoates or embonates. It has shown to have agonist activity for GPR35, an orphan G protein coupled receptor.
Storage TempArgon charged
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GPR35
Product Description

A naphthoic acid derivative.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR35 Tchem G-protein coupled receptor 35 6 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLB Tchem DNA polymerase beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APLNR Tchem Apelin receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488180825
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180825
IUPAC Name 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid
INCHI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
InChi Key WLJNZVDCPSBLRP-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
Isomeric SMILES C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
WGK Germany 3
RTECS QL2180000
PubChem CID 8546
Molecular Weight 388.37
Beilstein 901319
Reaxy-Rn 901319

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

20 results found

Lot NumberCertificate TypeDateItem
G2426554Certificate of AnalysisApr 30, 2024 P106763
G2426553Certificate of AnalysisApr 30, 2024 P106763
C1607100Certificate of AnalysisNov 01, 2023 P106763
G2322644Certificate of AnalysisJun 30, 2023 P106763
G2324070Certificate of AnalysisJun 30, 2023 P106763
G2324069Certificate of AnalysisJun 30, 2023 P106763
G2322984Certificate of AnalysisJun 30, 2023 P106763
G2322971Certificate of AnalysisJun 30, 2023 P106763
G2322647Certificate of AnalysisJun 30, 2023 P106763
G2322646Certificate of AnalysisJun 30, 2023 P106763
G2322645Certificate of AnalysisJun 30, 2023 P106763
G2322638Certificate of AnalysisJun 30, 2023 P106763
G2322634Certificate of AnalysisJun 30, 2023 P106763
D2324715Certificate of AnalysisMay 05, 2023 P106763
D2324705Certificate of AnalysisNov 08, 2021 P106763
C2211487Certificate of AnalysisNov 08, 2021 P106763
C2211486Certificate of AnalysisNov 08, 2021 P106763
C2211485Certificate of AnalysisNov 08, 2021 P106763
C2211484Certificate of AnalysisNov 08, 2021 P106763
C2211483Certificate of AnalysisNov 08, 2021 P106763

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Chemical and Physical Properties

SolubilitySoluble in nitrobenzene, pyridine.Insoluble in water, soluble in nitrobenzene, very slightly soluble in chloroform, insoluble in ether, alcohol, benzene
Melt Point(°C)≥300°C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS QL2180000
Reaxy-Rn 901319
Merck Index 7005

Related Documents

References

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6. M Jørgensen.  (1998-11-21)  Quantitative determination of pamoic acid in dog and rat serum by automated ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography..  Journal of chromatography. B, Biomedical sciences and applications,  716  ((1-2)): (315-323).  [PMID:9824246]
7. Jennifer L Best,Carlos A Amezcua,Bernhard Mayr,Lawrence Flechner,Christopher M Murawsky,Beverly Emerson,Tsaffrir Zor,Kevin H Gardner,Marc Montminy.  (2004-12-09)  Identification of small-molecule antagonists that inhibit an activator: coactivator interaction..  Proceedings of the National Academy of Sciences of the United States of America,  101  ((51)): (17622-17627).  [PMID:15585582]
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9. Corinne Hazan,François Boudsocq,Virginie Gervais,Olivier Saurel,Marion Ciais,Christophe Cazaux,Jerzy Czaplicki,Alain Milon.  (2008-04-18)  Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors..  BMC structural biology,  (22-22).  [PMID:18416825]
10. Chad Deisenroth,Aaron R Thorner,Takeharu Enomoto,Charles M Perou,Yanping Zhang.  (2010-06-16)  Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53..  Molecular and cellular biology,  30  ((16)): (3981-3993).  [PMID:20547751]
11. Kristof Prinsen,Junjie Li,Hubert Vanbilloen,Peter Vermaelen,Ellen Devos,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen.  (2010-06-29)  Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography..  Bioorganic & medicinal chemistry,  18  ((14)): (5274-5281).  [PMID:20580560]
12. T Saesmaa,A M Tötterman.  (1990-01-01)  Dissolution studies on ampicillin embonate and amoxycillin embonate..  Journal of pharmaceutical and biomedical analysis,  ((1)): (61-65).  [PMID:2102266]
13. R W Roos,C A Lau-Cam.  (1986-12-24)  General reversed-phase high-performance liquid chromatographic method for the separation of drugs using triethylamine as a competing base..  Journal of chromatography,  370  ((3)): (403-418).  [PMID:3818820]
14. O Gavrilova-Ruch,K Schönherr,G Gessner,R Schönherr,T Klapperstück,W Wohlrab,S H Heinemann.  (2002-08-13)  Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells..  The Journal of membrane biology,  188  ((2)): (137-149).  [PMID:12172639]
15. Hong-Yu Hu,Julie K Horton,Michael R Gryk,Rajendra Prasad,Jana M Naron,Di-An Sun,Sidney M Hecht,Samuel H Wilson,Gregory P Mullen.  (2004-07-20)  Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping..  The Journal of biological chemistry,  279  ((38)): (39736-39744).  [PMID:15258144]
16. Ju-Yi Hsieh,Shao-Yu Li,Wen-Chen Tsai,Jyung-Hurng Liu,Chih-Li Lin,Guang-Yaw Liu,Hui-Chih Hung.  (2015-05-27)  A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence..  Oncotarget,  ((24)): (20084-20098).  [PMID:26008970]

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