Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P106763-5g | 5g | In stock | $9.90 | |
P106763-25g | 25g | In stock | $19.90 | |
P106763-100g | 100g | In stock | $68.90 | |
P106763-250g | 250g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $153.90 | |
P106763-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $277.90 |
Synonyms | 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) | DTXSID9048984 | NCGC00013369-02 | Pamosaeure | cid_25096 | MLS006011716 | NCGC00013369-03 | NCIStruc1_001097 | PAMOIC ACID | Pamoic acid, United States Pharmacopeia (USP) Reference Standard | CCG-37117 | 2-N |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Pamoic acid, also known as embonic acid, is the free acid form of pamoates or embonates. It has shown to have agonist activity for GPR35, an orphan G protein coupled receptor. |
Storage Temp | Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of GPR35 |
Product Description | A naphthoic acid derivative. |
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Pubchem Sid | 488180825 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180825 |
IUPAC Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid |
INCHI | InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29) |
InChi Key | WLJNZVDCPSBLRP-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O |
Isomeric SMILES | C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O |
WGK Germany | 3 |
RTECS | QL2180000 |
PubChem CID | 8546 |
Molecular Weight | 388.37 |
Beilstein | 901319 |
Reaxy-Rn | 901319 |
PubChem CID | 8546 |
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Wikipedia | Pamoic_acid |
BindingDB Ligand | 50143426 |
CAS Registry No. | 130-85-8 |
ChEMBL Ligand | CHEMBL177880 |
RCSB PDB Ligand | JBR |
GPCRdb Ligand | pamoic acid |
PubChem SID | 488180825 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2426554 | Certificate of Analysis | Apr 30, 2024 | P106763 |
G2426553 | Certificate of Analysis | Apr 30, 2024 | P106763 |
C1607100 | Certificate of Analysis | Nov 01, 2023 | P106763 |
G2322644 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2324070 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2324069 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322984 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322971 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322647 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322646 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322645 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322638 | Certificate of Analysis | Jun 30, 2023 | P106763 |
G2322634 | Certificate of Analysis | Jun 30, 2023 | P106763 |
D2324715 | Certificate of Analysis | May 05, 2023 | P106763 |
D2324705 | Certificate of Analysis | Nov 08, 2021 | P106763 |
C2211487 | Certificate of Analysis | Nov 08, 2021 | P106763 |
C2211486 | Certificate of Analysis | Nov 08, 2021 | P106763 |
C2211485 | Certificate of Analysis | Nov 08, 2021 | P106763 |
C2211484 | Certificate of Analysis | Nov 08, 2021 | P106763 |
C2211483 | Certificate of Analysis | Nov 08, 2021 | P106763 |
Solubility | Soluble in nitrobenzene, pyridine.Insoluble in water, soluble in nitrobenzene, very slightly soluble in chloroform, insoluble in ether, alcohol, benzene |
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Melt Point(°C) | ≥300°C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | QL2180000 |
Reaxy-Rn | 901319 |
Merck Index | 7005 |
1. Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME. (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.. Mol Pharmacol, 78 (4): (560-8). [PMID:20826425] |
2. T Saesmaa. (1989-02-03) Identification and purity determination of benzathine and embonate salts of some beta-lactam antibiotics by thin-layer chromatography.. Journal of chromatography, 463 ((2)): (469-473). [PMID:2708491] |
3. T Saesmaa. (1988-11-25) Quantitative high-performance liquid chromatographic determination of ampicillin embonate and amoxycillin embonate.. Journal of chromatography, 455 (415-419). [PMID:3235621] |
4. H M Ruijten,P H van Amsterdam,H de Bree. (1984-11-30) Conical precolumn as loading buffer for the main column.. Journal of chromatography, 314 (183-191). [PMID:6526878] |
5. S Handali,H Liying,C Lusikoy,J Senis,D Sihombing. (1997-01-01) A survey report--July 1993: cysticercosis in the Grand Dani Valley, Jayawijaya District, Irian Jaya Province, Indonesia.. The Southeast Asian journal of tropical medicine and public health, 28 Suppl 1 (22-25). [PMID:9656343] |
6. M Jørgensen. (1998-11-21) Quantitative determination of pamoic acid in dog and rat serum by automated ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography.. Journal of chromatography. B, Biomedical sciences and applications, 716 ((1-2)): (315-323). [PMID:9824246] |
7. Jennifer L Best,Carlos A Amezcua,Bernhard Mayr,Lawrence Flechner,Christopher M Murawsky,Beverly Emerson,Tsaffrir Zor,Kevin H Gardner,Marc Montminy. (2004-12-09) Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.. Proceedings of the National Academy of Sciences of the United States of America, 101 ((51)): (17622-17627). [PMID:15585582] |
8. Humphrey Fonge,Satish K Chitneni,Jin Lixin,Kathleen Vunckx,Kristof Prinsen,Johan Nuyts,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen. (2007-10-13) Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis.. Bioconjugate chemistry, 18 ((6)): (1924-1934). [PMID:17929883] |
9. Corinne Hazan,François Boudsocq,Virginie Gervais,Olivier Saurel,Marion Ciais,Christophe Cazaux,Jerzy Czaplicki,Alain Milon. (2008-04-18) Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors.. BMC structural biology, 8 (22-22). [PMID:18416825] |
10. Chad Deisenroth,Aaron R Thorner,Takeharu Enomoto,Charles M Perou,Yanping Zhang. (2010-06-16) Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.. Molecular and cellular biology, 30 ((16)): (3981-3993). [PMID:20547751] |
11. Kristof Prinsen,Junjie Li,Hubert Vanbilloen,Peter Vermaelen,Ellen Devos,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen. (2010-06-29) Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography.. Bioorganic & medicinal chemistry, 18 ((14)): (5274-5281). [PMID:20580560] |
12. T Saesmaa,A M Tötterman. (1990-01-01) Dissolution studies on ampicillin embonate and amoxycillin embonate.. Journal of pharmaceutical and biomedical analysis, 8 ((1)): (61-65). [PMID:2102266] |
13. R W Roos,C A Lau-Cam. (1986-12-24) General reversed-phase high-performance liquid chromatographic method for the separation of drugs using triethylamine as a competing base.. Journal of chromatography, 370 ((3)): (403-418). [PMID:3818820] |
14. O Gavrilova-Ruch,K Schönherr,G Gessner,R Schönherr,T Klapperstück,W Wohlrab,S H Heinemann. (2002-08-13) Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells.. The Journal of membrane biology, 188 ((2)): (137-149). [PMID:12172639] |
15. Hong-Yu Hu,Julie K Horton,Michael R Gryk,Rajendra Prasad,Jana M Naron,Di-An Sun,Sidney M Hecht,Samuel H Wilson,Gregory P Mullen. (2004-07-20) Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.. The Journal of biological chemistry, 279 ((38)): (39736-39744). [PMID:15258144] |
16. Ju-Yi Hsieh,Shao-Yu Li,Wen-Chen Tsai,Jyung-Hurng Liu,Chih-Li Lin,Guang-Yaw Liu,Hui-Chih Hung. (2015-05-27) A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence.. Oncotarget, 6 ((24)): (20084-20098). [PMID:26008970] |