Pamoic acid - 97%, high purity , CAS No.130-85-8, Agonist of GPR35

Item Number
P106763
Grouped product items
SKUSizeAvailabilityPrice Qty
P106763-5g
5g
In stock
$9.90
P106763-25g
25g
In stock
$19.90
P106763-100g
100g
In stock
$68.90
P106763-250g
250g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$153.90
P106763-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$277.90
View related series
GPR35 Agonist

Basic Description

Synonyms4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) | DTXSID9048984 | NCGC00013369-02 | Pamosaeure | cid_25096 | MLS006011716 | NCGC00013369-03 | NCIStruc1_001097 | PAMOIC ACID | Pamoic acid, United States Pharmacopeia (USP) Reference Standard | CCG-37117 | 2-N
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPamoic acid, also known as embonic acid, is the free acid form of pamoates or embonates. It has shown to have agonist activity for GPR35, an orphan G protein coupled receptor.
Storage TempArgon charged
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GPR35
Product Description

A naphthoic acid derivative.

Associated Targets(Human)

GPR35 Tchem G-protein coupled receptor 35 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-4 (44535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-19 (46794 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-257 (46019 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC 2998 (41480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Aplnr Apelin receptor (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTP1 Protein-tyrosine phosphatase 1 (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488180825
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180825
IUPAC Name 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid
INCHI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
InChi Key WLJNZVDCPSBLRP-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
Isomeric SMILES C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
WGK Germany 3
RTECS QL2180000
PubChem CID 8546
Molecular Weight 388.37
Beilstein 901319
Reaxy-Rn 901319

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot NumberCertificate TypeDateItem
G2426554Certificate of AnalysisApr 30, 2024 P106763
G2426553Certificate of AnalysisApr 30, 2024 P106763
C1607100Certificate of AnalysisNov 01, 2023 P106763
G2322644Certificate of AnalysisJun 30, 2023 P106763
G2324070Certificate of AnalysisJun 30, 2023 P106763
G2324069Certificate of AnalysisJun 30, 2023 P106763
G2322984Certificate of AnalysisJun 30, 2023 P106763
G2322971Certificate of AnalysisJun 30, 2023 P106763
G2322647Certificate of AnalysisJun 30, 2023 P106763
G2322646Certificate of AnalysisJun 30, 2023 P106763
G2322645Certificate of AnalysisJun 30, 2023 P106763
G2322638Certificate of AnalysisJun 30, 2023 P106763
G2322634Certificate of AnalysisJun 30, 2023 P106763
D2324715Certificate of AnalysisMay 05, 2023 P106763
D2324705Certificate of AnalysisNov 08, 2021 P106763
C2211487Certificate of AnalysisNov 08, 2021 P106763
C2211486Certificate of AnalysisNov 08, 2021 P106763
C2211485Certificate of AnalysisNov 08, 2021 P106763
C2211484Certificate of AnalysisNov 08, 2021 P106763
C2211483Certificate of AnalysisNov 08, 2021 P106763

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Chemical and Physical Properties

SolubilitySoluble in nitrobenzene, pyridine.Insoluble in water, soluble in nitrobenzene, very slightly soluble in chloroform, insoluble in ether, alcohol, benzene
Melt Point(°C)≥300°C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS QL2180000
Reaxy-Rn 901319
Merck Index 7005

Related Documents

References

1. Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME.  (2010)  Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity..  Mol Pharmacol,  78  (4): (560-8).  [PMID:20826425]
2. T Saesmaa.  (1989-02-03)  Identification and purity determination of benzathine and embonate salts of some beta-lactam antibiotics by thin-layer chromatography..  Journal of chromatography,  463  ((2)): (469-473).  [PMID:2708491]
3. T Saesmaa.  (1988-11-25)  Quantitative high-performance liquid chromatographic determination of ampicillin embonate and amoxycillin embonate..  Journal of chromatography,  455  (415-419).  [PMID:3235621]
4. H M Ruijten,P H van Amsterdam,H de Bree.  (1984-11-30)  Conical precolumn as loading buffer for the main column..  Journal of chromatography,  314  (183-191).  [PMID:6526878]
5. S Handali,H Liying,C Lusikoy,J Senis,D Sihombing.  (1997-01-01)  A survey report--July 1993: cysticercosis in the Grand Dani Valley, Jayawijaya District, Irian Jaya Province, Indonesia..  The Southeast Asian journal of tropical medicine and public health,  28 Suppl 1  (22-25).  [PMID:9656343]
6. M Jørgensen.  (1998-11-21)  Quantitative determination of pamoic acid in dog and rat serum by automated ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography..  Journal of chromatography. B, Biomedical sciences and applications,  716  ((1-2)): (315-323).  [PMID:9824246]
7. Jennifer L Best,Carlos A Amezcua,Bernhard Mayr,Lawrence Flechner,Christopher M Murawsky,Beverly Emerson,Tsaffrir Zor,Kevin H Gardner,Marc Montminy.  (2004-12-09)  Identification of small-molecule antagonists that inhibit an activator: coactivator interaction..  Proceedings of the National Academy of Sciences of the United States of America,  101  ((51)): (17622-17627).  [PMID:15585582]
8. Humphrey Fonge,Satish K Chitneni,Jin Lixin,Kathleen Vunckx,Kristof Prinsen,Johan Nuyts,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen.  (2007-10-13)  Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis..  Bioconjugate chemistry,  18  ((6)): (1924-1934).  [PMID:17929883]
9. Corinne Hazan,François Boudsocq,Virginie Gervais,Olivier Saurel,Marion Ciais,Christophe Cazaux,Jerzy Czaplicki,Alain Milon.  (2008-04-18)  Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors..  BMC structural biology,  (22-22).  [PMID:18416825]
10. Chad Deisenroth,Aaron R Thorner,Takeharu Enomoto,Charles M Perou,Yanping Zhang.  (2010-06-16)  Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53..  Molecular and cellular biology,  30  ((16)): (3981-3993).  [PMID:20547751]
11. Kristof Prinsen,Junjie Li,Hubert Vanbilloen,Peter Vermaelen,Ellen Devos,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen.  (2010-06-29)  Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography..  Bioorganic & medicinal chemistry,  18  ((14)): (5274-5281).  [PMID:20580560]
12. T Saesmaa,A M Tötterman.  (1990-01-01)  Dissolution studies on ampicillin embonate and amoxycillin embonate..  Journal of pharmaceutical and biomedical analysis,  ((1)): (61-65).  [PMID:2102266]
13. R W Roos,C A Lau-Cam.  (1986-12-24)  General reversed-phase high-performance liquid chromatographic method for the separation of drugs using triethylamine as a competing base..  Journal of chromatography,  370  ((3)): (403-418).  [PMID:3818820]
14. O Gavrilova-Ruch,K Schönherr,G Gessner,R Schönherr,T Klapperstück,W Wohlrab,S H Heinemann.  (2002-08-13)  Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells..  The Journal of membrane biology,  188  ((2)): (137-149).  [PMID:12172639]
15. Hong-Yu Hu,Julie K Horton,Michael R Gryk,Rajendra Prasad,Jana M Naron,Di-An Sun,Sidney M Hecht,Samuel H Wilson,Gregory P Mullen.  (2004-07-20)  Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping..  The Journal of biological chemistry,  279  ((38)): (39736-39744).  [PMID:15258144]
16. Ju-Yi Hsieh,Shao-Yu Li,Wen-Chen Tsai,Jyung-Hurng Liu,Chih-Li Lin,Guang-Yaw Liu,Hui-Chih Hung.  (2015-05-27)  A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence..  Oncotarget,  ((24)): (20084-20098).  [PMID:26008970]

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