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Pancuronium dibromide - ≥99%, high purity , CAS No.15500-66-0, Antagonist of nicotinic acetylcholine receptor α1 subunit

Moligand™
≥99%

CAS#: 15500-66-0
Formula: C₃₅H₆₀Br₂N₂O₄
Molecular Weight: 732.67
Beilstein Registry Number: 4226892
EC Number: 239-532-5
MDL number: MFCD00079223
PubChem CID: 27350

Item Number

P129976

Grouped product items
SKU	Size	Availability	Price
P129976-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$260.90
P129976-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$587.90
P129976-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,114.90

Competitive nicotinic acetylcholine receptor (nAChR) antagonist

View related series

nicotinic acetylcholine receptor α1 subunit Antagonist

Basic Description

Synonyms	PANCURONIUM BROMIDE\|Pancuronium dibromide\|15500-66-0\|Pavulon\|Mioblock\|ORG NA 97\|Pancuronii bromidum\|bromurex\|Bromuro de pancuronio\|Bromure de pancuronium\|Pancuronium (dibromide)\|ORG-NA 97\|CHEBI:7908\|HSDB 3244\|EINECS 239-532-5\|UNII-U9LY9Y75X2\|ORG-NA-97\|NSC
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuroni
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of nicotinic acetylcholine receptor α1 subunit
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM. A nicotine neuromuscular antagonist.

Associated Targets

CBX1 Tbio Chromobox protein homolog 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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RAD52 Tchem DNA repair protein RAD52 homolog 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

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ABCC3 Tbio Canalicular multispecific organic anion transporter 2 0 Activities

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ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA1 Tclin Acetylcholine receptor subunit alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB11 Tchem Bile salt export pump 0 Activities

Discover Target: ABCB11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 0 Activities

Discover Target: KCNN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide
INCHI	InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
InChi Key	NPIJXCQZLFKBMV-YTGGZNJNSA-L
Canonical SMILES	CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
Isomeric SMILES	CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
WGK Germany	3
RTECS	TN4930000
PubChem CID	27350
Molecular Weight	732.67
Beilstein	4226892

DrugBank Ligand

Wikipedia

CAS Registry No.

PubChem CID

ChEMBL Ligand

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
J2311172	Certificate of Analysis	Aug 10, 2023	P129976
J2311173	Certificate of Analysis	Aug 10, 2023	P129976
J2311174	Certificate of Analysis	Aug 10, 2023	P129976

Solubility

Soluble in water (100 mM), ethanol (100 mg/ml at 25 °C), and DMSO (100 mg/ml at 25 °C).

Sensitivity

Moisture & light & air sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.
WGK Germany	3
RTECS	TN4930000

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