Basic Description

Product Name	Panitumumab (anti-EGFR) - Primary antibody, for Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) various applications, specific to EGFR, >95%, high purity, Human IgG2SA
Synonyms	Panitumumab \| ABX-EGF \| Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody \| Cell growth inhibiting protein 40 antibody \| Cell proliferation inducing protein 61 antibody \| EGF R antibody \| EGFR antibody \| EGFR_HUMAN antibody \| Epiderm
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Host species	Human
Specificity	EGFR
Application	Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR)
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of epidermal growth factor receptor
Product Description	Panitumumab is an anti- EGFR monoclonal antibody with anti-tumor activity. It inhibits tumor cell proliferation, survival and angiogenesis. And it can be used in the research of cancers, such as colon cancer. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Human IgG2SA
Light Chain Type	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 170.3 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95%
Source	CHO supernatant
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	339177-26-3

Images

Panitumumab (anti-EGFR) (Ab169317) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR (red) with Panitumumab (anti-EGFR) (Ab169317). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Panitumumab (anti-EGFR) (Ab169317) - SEC
The purity of Panitumumab (anti-EGFR) (Ab169317) is more than 95% verified by HPLC.

Panitumumab (anti-EGFR) (Ab169317) - ELISA
Immobilized EGFR at 2 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 47.19 ng/mL.

Panitumumab (anti-EGFR) (Ab169317) - ELISA
Immobilized Recombinant Human EGFR protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 23.66 ng/mL.

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor (0 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin MER intracellular domain/EGFR extracellular domain chimera (2 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Protein cereblon/Epidermal growth factor receptor (191 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin EGFR/PPP1CA (1 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin VHL/EGFR (323 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Baculoviral IAP repeat-containing protein 2/Epidermal growth factor receptor (1 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Database links

IMGT/mAb-DB	196
Wikipedia	Panitumumab

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

FAQs and Articles

FAQ

Flow cytometry protocol

Categories: Protocols

Tags:

Antibodies Flow Cytometry Flow Antibodies Reactive dyes Indirect antibody labelling

References

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Panitumumab (anti-EGFR) - Primary antibody, for Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) various applications, specific to EGFR, >95%, high purity, Human IgG2SA, Antibody of epidermal growth factor receptor

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