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Panobinostat (LBH589) - ≥98%, high purity , CAS No.404950-80-7, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor of histone deacetylase 8;Inhibitor

Specifications & Purity:  ≥98%
Item Number
P125167
Grouped product items
SKUSizeAvailabilityPrice Qty
P125167-10mg
10mg
In stock
$64.90
P125167-50mg
50mg
In stock
$129.90
P125167-100mg
100mg
In stock
$177.90
P125167-250mg
250mg
In stock
$400.90
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View related series
histone deacetylase 1 Inhibitor histone deacetylase 2 Inhibitor histone deacetylase 3 Inhibitor histone deacetylase 4 Inhibitor histone deacetylase 6 Inhibitor histone deacetylase 7 Inhibitor histone deacetylase 8 Inhibitor histone deacetylase 9 Inhibitor Plasmodium falciparum histone deacetylase 1

Basic Description

SynonymsPanobinostat|404950-80-7|LBH589|LBH-589|Farydak|Faridak|Panobinostat (LBH589)|LBH 589|(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide|NVP-LBH589|NVP-LBH-589|UNII-9647FM7Y3Z|LBH-589B|CHEBI:85990|9647FM7Y3Z|Panobinostat(
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionInhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor of histone deacetylase 8;Inhibitor

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC4 Tclin Histone deacetylase 4 13 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 19 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 25 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC11 Tclin Histone deacetylase 11 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 7 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 17 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 6 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 13 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 9 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 14 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488195886
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195886
IUPAC Name (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
INCHI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChi Key FPOHNWQLNRZRFC-ZHACJKMWSA-N
Canonical SMILES CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
Isomeric SMILES CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
PubChem CID 6918837
Molecular Weight 349.44

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

9 results found

Lot NumberCertificate TypeDateItem
K2125279Certificate of AnalysisSep 11, 2023 P125167
K2125289Certificate of AnalysisSep 11, 2023 P125167
K2125291Certificate of AnalysisSep 11, 2023 P125167
B2303014Certificate of AnalysisNov 26, 2022 P125167
B2303098Certificate of AnalysisNov 26, 2022 P125167
B2303104Certificate of AnalysisNov 26, 2022 P125167
B2303536Certificate of AnalysisNov 26, 2022 P125167
B2303538Certificate of AnalysisNov 26, 2022 P125167
B2303539Certificate of AnalysisNov 26, 2022 P125167

Chemical and Physical Properties

SolubilitySoluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).

Related Documents

 SDS

 Specification Sheet

References

1. Mack GS.  (2010)  To selectivity and beyond..  Nat Biotechnol,  28  (12): (1259-66).  [PMID:21139608]
2. Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Skinner-Adams T, Andrews KT.  (2015)  Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites..  Int J Parasitol Drugs Drug Resist,  5  (3): (117-26).  [PMID:26199860]
3. Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N et al..  (2008)  Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors..  Biochem J,  409  (2): (581-9).  [PMID:17868033]

Solution Calculators

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