Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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P275480-250mg | 250mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $9.90 | |
P275480-1g | 1g | In stock | $29.90 | |
P275480-5g | 5g | In stock | $99.90 |
Potent, selective PDE10A inhibitor
Synonyms | Chlorhydrate de papaverine | Pavabid | Pavagrant | Qua bid | Tox21_110226 | Tox21_110226_1 | CCG-40065 | Papavarine hydrochloride | PAPAVERINE HYDROCHLORIDE (USP-RS) | Pavabid (TN) | MLS002222208 | CS-5015 | Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydroc |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Potent and selective PDE10A inhibitor (IC 50 values are 17 and 284 nM for PDE10A and PDE3A respectively). Shows smooth muscle relaxant, antispasmodic and vasodilatory effects in vivo. Orally active. |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. Product Application: Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy。 Papaverine hydrochloride has been used: in oxygenated Krebs solution for tissue mechanics analysis; as a vasodilator in heparinized horse serum in tissue uptake technique; as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488180003 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180003 |
IUPAC Name | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride |
INCHI | InChI=1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H |
InChi Key | UOTMYNBWXDUBNX-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl |
Isomeric SMILES | COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl |
PubChem CID | 6084 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 375.86 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2426617 | Certificate of Analysis | Nov 14, 2024 | P275480 |
K2426618 | Certificate of Analysis | Nov 14, 2024 | P275480 |
K2426632 | Certificate of Analysis | Nov 14, 2024 | P275480 |
J2429192 | Certificate of Analysis | Nov 02, 2024 | P275480 |
D23181094 | Certificate of Analysis | Feb 23, 2024 | P275480 |
D23181110 | Certificate of Analysis | Feb 23, 2024 | P275480 |
D23181123 | Certificate of Analysis | Feb 23, 2024 | P275480 |
D23181089 | Certificate of Analysis | Feb 01, 2024 | P275480 |
D23181102 | Certificate of Analysis | Feb 01, 2024 | P275480 |
D23181101 | Certificate of Analysis | Apr 08, 2023 | P275480 |
B2324618 | Certificate of Analysis | Feb 15, 2023 | P275480 |
B2324822 | Certificate of Analysis | Feb 15, 2023 | P275480 |
Solubility | Soluble in water,DMSO,ethanol |
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Sensitivity | air and light sensitive |
Melt Point(°C) | 220 - 225 °C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H302:Harmful if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. |
Class | 6.1 |