Basic Description

Synonyms	patulin \| 149-29-1 \| Clavacin \| Clavatin \| Expansin \| Patuline \| Expansine \| Claviformin \| Claviform \| Clairformin \| Leucopin \| Terinin \| Gigantin \| Mycoin \| Mycoin C3 \| Penicidin \| Tercinin \| Mycoine C3 \| Mycosin \| Penatin \| Mycoin C \| 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one \| 4H-Furo[3,2-c]pyran-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Fungal mycotoxin, DNA damaging agent and induces ROS production. Apoptosis inducer via EGR-1 dependent ATF3 upregulation in vitro . Anti-bacterial, carcinogenic, mutagenic and anticancer agent. Active in vivo .
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins. An inhibitor of protein prenylation

Associated Targets(Human)

CDK1 Tchem Cyclin-dependent kinase 1 (0 Activities)

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CFL1 Tbio Cofilin-1 (0 Activities)

Discover Target: CFL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor (0 Activities)

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor (0 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor (0 Activities)

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 (0 Activities)

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JUN Tchem Transcription factor AP-1 (0 Activities)

Discover Target: JUN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein (0 Activities)

Discover Target: SMN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha (0 Activities)

Discover Target: RXRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK12 Tchem Mitogen-activated protein kinase 12 (0 Activities)

Discover Target: MAPK12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H4 Tclin Bile acid receptor (0 Activities)

Discover Target: NR1H4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSPA5 Tchem Endoplasmic reticulum chaperone BiP (0 Activities)

Discover Target: HSPA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (0 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AHR Tclin Aryl hydrocarbon receptor (0 Activities)

Discover Target: AHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta (0 Activities)

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau (0 Activities)

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCHE Tclin Cholinesterase (0 Activities)

Discover Target: BCHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 (0 Activities)

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta (0 Activities)

Discover Target: PPARD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma (0 Activities)

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 (0 Activities)

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JUN Tchem Proto-oncogene c-JUN (434 Activities)

Discover Target: JUN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

Discover Target: AHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

Discover Target: NR1H4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK1 Tchem Cyclin-dependent kinase 1 (3927 Activities)

Discover Target: CDK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAKI-1 (44928 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCRF-CEM (65223 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

COLO 205 (50209 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DLD-1 (17511 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DMS-273 (14108 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-29 (80576 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

K562 (73714 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KM12 (47707 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLT-4 (49676 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-3 (48710 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-4 (44535 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-5 (45555 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-8 (47708 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPMI-8226 (44974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXF 393 (41971 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SF-295 (48000 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-2 (46422 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-28 (48833 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-5 (47095 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-OV-3 (52876 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SN12C (47755 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNB-19 (46794 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNB-78 (14240 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-251 (51189 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UACC-257 (46019 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UACC-62 (47335 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UO-31 (46270 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

XF498 (12972 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI/ADR-RES (33767 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EKVX (44102 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H322M (45589 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCC 2998 (41480 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

Discover Target: Ppard

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agrobacterium tumefaciens (620 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388 (20296 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388/ADR (1216 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS3 NS3 (1121 Activities)

Discover Target: NS3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

groL GroEL/GroES (1042 Activities)

Discover Target: groL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ebolavirus (617 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
INCHI	InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
InChi Key	ZRWPUFFVAOMMNM-UHFFFAOYSA-N
Canonical SMILES	C1C=C2C(=CC(=O)O2)C(O1)O
Isomeric SMILES	C1C=C2C(=CC(=O)O2)C(O1)O
WGK Germany	3
PubChem CID	4696
UN Number	3462
Molecular Weight	154.12
Beilstein	149675

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
G2222659	Certificate of Analysis	Jun 18, 2022	P113515
G2222660	Certificate of Analysis	Jun 18, 2022	P113515
G2222661	Certificate of Analysis	Jun 18, 2022	P113515

Chemical and Physical Properties

Solubility	Soluble in water, 100% ethanol (25 mg/mL), ethyl acetate (50 mg/mL), amyl acetate, DMSO (10 mg/mL), acetone, ethyl ether (sparingly), benzene (sparingly), and dichloromethane (10 mg/mL)
Sensitivity	Light sensitive;Moisture sensitive
Melt Point(°C)	108-111°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H300:Fatal if swallowed
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	3

Citations of This Product

1. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486]
2. Yumeng Liao, Nan Zhang, Danni Chai, Boshi Liu, Jingrong Li, Yuting Fang, Di Zhang, Rui Liu, Zheng Li. (2023) Rational design of ratiometric fluorescent aptasensor for patulin in traditional Chinese medicine through the studies of interaction mechanism between DNA aptamer and target molecule. ANALYST, (3): [PMID:37725068]
3. Chen Hu, Caiping Huang, Bangzhu Peng. (2023) Study on the mechanism of photocatalytic degradation of patulin in simulated apple juice. FOOD CHEMISTRY, 426 (136592). [PMID:37354573]
4. Xiaobing Yang, Junjie Pan, Jiapeng Hu, Shengyun Zhao, Kejun Cheng. (2023) MOF-derived La–ZnFe2O4@Fe3O4@carbon magnetic hybrid composite as a highly efficient and recyclable photocatalyst for mycotoxins degradation. CHEMICAL ENGINEERING JOURNAL, 467 (143381). [PMID:]
5. Lei Jiang, Lin Yuan, Shan Gao, Yingying Xiang, Fei Song, Wensi Ma, Jing Wan, Xiuling Ji, Yujiao Tu. (2023) Facile hydrothermal synthesis of N-doped fluorescent carbon dots for selective detection of insecticide parathion. Analytical Methods, 15 (19): (2376-2381). [PMID:37132329]
6. Sai Zhang, Yahui Wang, Qinglin Sheng, Tianli Yue. (2023) Electrochemical Aptasensor Based on ZnO-Au Nanocomposites for the Determination of Ochratoxin A in Wine and Beer. Processes, 11 (3): (864). [PMID:]
7. Dongyan Tian, Jie Wang, Qiandong Zhuang, Songmei Wu, Yu Yu, Kejian Ding. (2023) An electrochemiluminescence biosensor based on Graphitic carbon nitride luminescence quenching for detection of AFB1. FOOD CHEMISTRY, 404 (134183). [PMID:36240563]
8. Hui Chen, Lixing Cao, Kai Han, Han Zhang, Jinling Cui, Xuan Ma, Shuang Zhao, Chong Zhao, Shutao Yin, Lihong Fan, Hongbo Hu. (2022) Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. FOOD AND CHEMICAL TOXICOLOGY, 166 (113255). [PMID:35772596]
9. Lu Yang, Jin Wang, Huan Lv, Xue-Meng Ji, Jing-Min Liu, Shuo Wang. (2022) Hollow-Structured Microporous Organic Networks Adsorbents Enabled Specific and Sensitive Identification and Determination of Aflatoxins. Toxins, 14 (2): (137). [PMID:35202164]

References

1. Krutzik PO, Crane JM, Clutter MR, Nolan GP,. () High-content single-cell drug screening with phosphospecific flow cytometry.. Nat Chem Biol, [PMID:18157122]
2. . (1976-01-01) Patulin.. IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 10 (205-210). [PMID:791801]
3. G Criseo,R Guerrisi,F Forestieri. (1990-09-01) [Patulin].. Annali di igiene : medicina preventiva e di comunita, 2 ((5)): (343-352). [PMID:1715725]
4. G S Shephard,N L Leggott. (2000-07-15) Chromatographic determination of the mycotoxin patulin in fruit and fruit juices.. Journal of chromatography. A, 882 ((1-2)): (17-22). [PMID:10895928]
5. John A G Roach,Allan R Brause,Thomas A Eisele,Heidi S Rupp. (2002-04-02) Hplc detection of patulin in apple juice with GC/MS confirmation of patulin identity.. Advances in experimental medicine and biology, 504 (135-140). [PMID:11924597]
6. J B KAHN. (1957-10-01) Effects of various lactones and related compounds on cation transfer in incubated cold-stored human erythrocytes.. The Journal of pharmacology and experimental therapeutics, 121 ((2)): (234-251). [PMID:13481846]
7. Christopher P Gordon,Paul A Keller. (2005-01-07) Control of hepatitis C: a medicinal chemistry perspective.. Journal of medicinal chemistry, 48 ((1)): (1-20). [PMID:15633995]
8. Seong-Won Nam,Xiaoqiang Chen,Jeesun Lim,So Hyun Kim,Sang-Tae Kim,You-Hee Cho,Juyoung Yoon,Sungsu Park. (2011-07-14) In vivo fluorescence imaging of bacteriogenic cyanide in the lungs of live mice infected with cystic fibrosis pathogens.. PloS one, 6 ((7)): (e21387-e21387). [PMID:21750709]
9. Olivier Puel,Pierre Galtier,Isabelle P Oswald. (2010-04-01) Biosynthesis and toxicological effects of patulin.. Toxins, 2 ((4)): (613-631). [PMID:22069602]
10. Shaimaa Hatab,Tianli Yue,Osama Mohamad. (2012-03-08) Reduction of patulin in aqueous solution by lactic acid bacteria.. Journal of food science, 77 ((4)): (M238-M241). [PMID:22394296]
11. Nina Glaser,Helga Stopper. (2012-03-20) Patulin: Mechanism of genotoxicity.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 ((5)): (1796-1801). [PMID:22425938]
12. Kitipong Assatarakul,John J Churey,David C Manns,Randy W Worobo. (2012-04-11) Patulin reduction in apple juice from concentrate by UV radiation and comparison of kinetic degradation models between apple juice and apple cider.. Journal of food protection, 75 ((4)): (717-724). [PMID:22488060]
13. Setsuko Tabata. (2012-07-14) [Analytical methods for mycotoxins].. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 53 ((3)): (129-138). [PMID:22790714]
14. Ting-Shuan Wu,Jiann-Jou Yang,Feng-Yih Yu,Biing-Hui Liu. (2012-08-01) Evaluation of nephrotoxic effects of mycotoxins, citrinin and patulin, on zebrafish (Danio rerio) embryos.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 ((12)): (4398-4404). [PMID:22847133]
15. Eszter Horváth,Nikoletta Kálmán,M Pesti,K Iwata,S Kunsági-Máté. (2012-09-12) Thermodynamic and kinetic processes during the unfolding of BSA in the presence of the mycotoxin patulin.. Acta biologica Hungarica, 63 ((3)): (389-398). [PMID:22963919]
16. Tufan Güray,Muzaffer Tuncel,Ulku Dilek Uysal. (2012-09-19) A rapid determination of patulin using capillary zone electrophoresis and its application to analysis of apple juices.. Journal of chromatographic science, 51 ((4)): (310-317). [PMID:22988003]
17. Svetlana V Malysheva,José Diana Di Mavungu,Jente Boonen,Bart De Spiegeleer,Irina Yu Goryacheva,Lynn Vanhaecke,Sarah De Saeger. (2012-11-28) Improved positive electrospray ionization of patulin by adduct formation: usefulness in liquid chromatography-tandem mass spectrometry multi-mycotoxin analysis.. Journal of chromatography. A, 1270 (334-339). [PMID:23182278]
18. Hua Niu,Lei Feng,Zhirui Niu,Na Zhu,Hongkun Zhu,Yaqin Wang. (2013-01-05) [Determination of patulin in juice by ultra performance liquid chromatography-tandem mass spectrometry].. Se pu = Chinese journal of chromatography, 30 ((9)): (957-961). [PMID:23285980]
19. Tomoyasu Taguchi,Daisuke Kozutsumi,Ruka Nakamura,Yoshio Sato,Atsushi Ishihara,Hiromitsu Nakajima. (2013-01-08) Effects of aliphatic aldehydes on the growth and patulin production of Penicillium expansum in apple juice.. Bioscience, biotechnology, and biochemistry, 77 ((1)): (138-144). [PMID:23291770]
20. H Morales,R R M Paterson,A Venâncio,N Lima. (2013-02-07) Interaction with Penicillium expansum enhances Botrytis cinerea growth in grape juice medium and prevents patulin accumulation in vitro.. Letters in applied microbiology, 56 ((5)): (356-360). [PMID:23384314]
21. Wenlu Song,Charlie Li,Bahman Moezzi. (2013-02-19) Simultaneous determination of bisphenol A, aflatoxin B1, ochratoxin A, and patulin in food matrices by liquid chromatography/mass spectrometry.. Rapid communications in mass spectrometry : RCM, 27 ((6)): (671-680). [PMID:23418146]
22. Anastasios A Malandrakis,Anastasios N Markoglou,Sotiris Konstantinou,Eleftherios G Doukas,John F Kalampokis,George S Karaoglanidis. (2013-03-05) Molecular characterization, fitness and mycotoxin production of benzimidazole-resistant isolates of Penicillium expansum.. International journal of food microbiology, 162 ((3)): (237-244). [PMID:23454814]
23. Yan Zhu,Tatiana Koutchma,Keith Warriner,Suqin Shao,Ting Zhou. (2013-06-05) Kinetics of patulin degradation in model solution, apple cider and apple juice by ultraviolet radiation.. Food science and technology international = Ciencia y tecnologia de los alimentos internacional, 19 ((4)): (291-303). [PMID:23729413]
24. S Bräse,F Gläser,C S Kramer,S Lindner,A M Linsenmeier,K-S Masters,A C Meister,B M Ruff,S Zhong. (2013-06-21) Progress in the chemistry of organic natural products. The chemistry of mycotoxins.. Progress in the chemistry of organic natural products, 97 (v-xv). [PMID:23781707]
25. A Mueller,U Schlink,G Wichmann,M Bauer,C Graebsch,G Schüürmann,O Herbarth. (2013-07-16) Individual and combined effects of mycotoxins from typical indoor moulds.. Toxicology in vitro : an international journal published in association with BIBRA, 27 ((6)): (1970-1978). [PMID:23851004]
26. Eduardo Beltrán,María Ibáñez,Juan Vicente Sancho,Félix Hernández. (2013-09-05) Determination of patulin in apple and derived products by UHPLC-MS/MS. Study of matrix effects with atmospheric pressure ionisation sources.. Food chemistry, 142 (400-407). [PMID:24001858]
27. Erqun Song,Chuanyang Su,Juanli Fu,Xiaomin Xia,Siyu Yang,Congxue Xiao,Bin Lu,Hongjun Chen,Zhiyin Sun,Shanmei Wu,Yang Song. (2014-06-17) Selenium supplementation shows protective effects against patulin-induced brain damage in mice via increases in GSH-related enzyme activity and expression.. Life sciences, 109 ((1)): (37-43). [PMID:24931906]
28. Joanna Tannous,Rhoda El Khoury,Selma P Snini,Yannick Lippi,André El Khoury,Ali Atoui,Roger Lteif,Isabelle P Oswald,Olivier Puel. (2014-08-15) Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum.. International journal of food microbiology, 189 (51-60). [PMID:25120234]
29. Y Yuan,X Wang,S Hatab,Z Wang,Y Wang,Y Luo,T Yue. (2014-08-19) Patulin reduction in apple juice by inactivated Alicyclobacillus spp.. Letters in applied microbiology, 59 ((6)): (604-609). [PMID:25130934]
30. Florian Clatot,Marie Cornic,Anca Berghian,Vinciane Marchand,Olivier Choussy,Faissal El Ouakif,Arnaud François,Philippe Ruminy,Sophie Laberge-Le-Couteulx,Jean-Michel Picquenot,Fabrice Jardin. (2014-12-05) CXCL12 and CXCR4, but not CXCR7, are primarily expressed by the stroma in head and neck squamous cell carcinoma.. Pathology, 47 ((1)): (45-50). [PMID:25474514]
31. Yasushi Matsuzawa,Raviteja R Guddeti,Taek-Geun Kwon,Lilach O Lerman,Amir Lerman. (2015-03-06) Secondary prevention strategy of cardiovascular disease using endothelial function testing.. Circulation journal : official journal of the Japanese Circulation Society, 79 ((4)): (685-694). [PMID:25740088]
32. Marianna K Sayeg,Benjamin H Weinberg,Susie S Cha,Michael Goodloe,Wilson W Wong,Xue Han. (2015-04-08) Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain.. ACS synthetic biology, 4 ((7)): (788-795). [PMID:25848814]
33. Keiichi Torimoto,Yosuke Okada,Hiroko Mori,Takashi Otsuka,Mayuko Kawaguchi,Megumi Matsuda,Fumi Kuno,Kei Sugai,Satomi Sonoda,Maiko Hajime,Kenichi Tanaka,Tadashi Arao,Yoshiya Tanaka. (2015-04-08) Effects of exenatide on postprandial vascular endothelial dysfunction in type 2 diabetes mellitus.. Cardiovascular diabetology, 14 (25-25). [PMID:25849903]
34. Héctor Rodríguez-Sanz,María-Teresa Solís,María-Fernanda López,Aurelio Gómez-Cadenas,María C Risueño,Pilar S Testillano. (2015-04-25) Auxin Biosynthesis, Accumulation, Action and Transport are Involved in Stress-Induced Microspore Embryogenesis Initiation and Progression in Brassica napus.. Plant & cell physiology, 56 ((7)): (1401-1417). [PMID:25907568]
35. B Ubl,C Kuehner,P Kirsch,M Ruttorf,H Flor,C Diener. (2015-09-01) Neural reward processing in individuals remitted from major depression.. Psychological medicine, 45 ((16)): (3549-3558). [PMID:26315103]
36. Aiko Hayashi,Juan José Dorantes-Aranda,John P Bowman,Gustaaf Hallegraeff. (2018-12-14) Combined Cytotoxicity of the Phycotoxin Okadaic Acid and Mycotoxins on Intestinal and Neuroblastoma Human Cell Models.. Toxins, 10 ((12)): [PMID:30544794]
37. Safiye Selen Özcan,Markus Dieser,Albert E Parker,Narayanaganesh Balasubramanian,Christine M Foreman. (2019-04-26) Quorum sensing inhibition as a promising method to control biofilm growth in metalworking fluids.. Journal of industrial microbiology & biotechnology, 46 ((8)): (1103-1111). [PMID:31020467]
38. Yashodani Pillay,Terisha Ghazi,Shanel Raghubeer,Savania Nagiah,Anil A Chuturgoon. (2021-01-07) Patulin activates the NRF2 pathway by modulation of miR-144 expression in HEK293 cells.. Mycotoxin research, 37 ((1)): (97-103). [PMID:33403569]
39. K S Lee,R J Röschenthaler. (1986-11-01) DNA-damaging activity of patulin in Escherichia coli.. Applied and environmental microbiology, 52 ((5)): (1046-1054). [PMID:2431653]
40. Marie Pierre Artigot,Nicolas Loiseau,Joelle Laffitte,Lina Mas-Reguieg,Souria Tadrist,Isabelle P Oswald,Olivier Puel. (2009-04-23) Molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus.. Microbiology (Reading, England), 155 ((Pt 5)): (1738-1747). [PMID:19383676]
41. Alicia Rodríguez,Mar Rodríguez,María J Andrade,Juan J Córdoba. (2012-02-14) Development of a multiplex real-time PCR to quantify aflatoxin, ochratoxin A and patulin producing molds in foods.. International journal of food microbiology, 155 ((1-2)): (10-18). [PMID:22326179]
42. S Hatab,T Yue,O Mohamad. (2012-03-08) Removal of patulin from apple juice using inactivated lactic acid bacteria.. Journal of applied microbiology, 112 ((5)): (892-899). [PMID:22394257]
43. Caixia Guo,Tianli Yue,Shaimaa Hatab,Yahong Yuan. (2012-03-14) Ability of inactivated yeast powder to adsorb patulin from apple juice.. Journal of food protection, 75 ((3)): (585-590). [PMID:22410236]
44. Yuchun Zhou,Weijun Kong,Yan Li,Antonio F Logrieco,Jun Xu,Meihua Yang. (2012-04-21) A new solid-phase extraction and HPLC method for determination of patulin in apple products and hawthorn juice in China.. Journal of separation science, 35 ((5-6)): (641-649). [PMID:22517639]
45. Umberto Galvalisi,Sandra Lupo,Juan Piccini,Lina Bettucci. (2012-05-23) Penicillium species present in Uruguayan salami.. Revista Argentina de microbiologia, 44 ((1)): (36-42). [PMID:22610286]
46. Assunta Raiola,Giuseppe Meca,Guadalupe García-Llatas,Alberto Ritieni. (2012-06-13) Study of thermal resistance and in vitro bioaccessibility of patulin from artificially contaminated apple products.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 ((9)): (3068-3072). [PMID:22687554]
47. Gábor Papp,Eszter Horváth,Nóra Mike,Zoltán Gazdag,József Belágyi,Zoltán Gyöngyi,Gáspár Bánfalvi,László Hornok,Miklós Pesti. (2012-07-17) Regulation of patulin-induced oxidative stress processes in the fission yeast Schizosaccharomyces pombe.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 ((10)): (3792-3798). [PMID:22796319]
48. Marieke Vansteelandt,Isabelle Kerzaon,Elodie Blanchet,Olivia Fossi Tankoua,Thibaut Robiou Du Pont,Yolaine Joubert,Fabrice Monteau,Bruno Le Bizec,Jens C Frisvad,Yves François Pouchus,Olivier Grovel. (2012-09-08) Patulin and secondary metabolite production by marine-derived Penicillium strains.. Fungal biology, 116 ((9)): (954-961). [PMID:22954338]
49. Hong Xiao,Shanlin Fu. (2013-03-05) A sensitive gas chromatography-mass spectrometry method for the determination of patulin in apple juice.. Journal of AOAC International, 95 ((6)): (1709-1712). [PMID:23451387]
50. Shamshad Alam,Anu Pal,Rahul Kumar,Premendra D Dwivedi,Mukul Das,Kausar M Ansari. (2013-07-03) EGFR-mediated Akt and MAPKs signal pathways play a crucial role in patulin-induced cell proliferation in primary murine keratinocytes via modulation of Cyclin D1 and COX-2 expression.. Molecular carcinogenesis, 53 ((12)): (988-998). [PMID:23813870]
51. Niloofar Kharandi,Mehran Babri,Jila Azad. (2013-07-23) A novel method for determination of patulin in apple juices by GC-MS.. Food chemistry, 141 ((3)): (1619-1623). [PMID:23870868]
52. Megan H Touchette,Cynthia M Holsclaw,Mary L Previti,Viven C Solomon,Julie A Leary,Carolyn R Bertozzi,Jessica C Seeliger. (2014-10-22) The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis.. Journal of bacteriology, 197 ((1)): (201-210). [PMID:25331437]
53. Eun Gyung Lee,John H Nelson,Michael L Kashon,Martin Harper. (2015-03-05) Evaluation of the dark-medium objective lens in counting asbestos fibers by phase-contrast microscopy.. The Annals of occupational hygiene, 59 ((5)): (616-628). [PMID:25737333]
54. Chris M Maragos,Mark Busman,Liang Ma,John Bobell. (2015-04-03) Quantification of patulin in fruit leathers by ultra-high-performance liquid chromatography-photodiode array (UPLC-PDA).. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32 ((7)): (1164-1174). [PMID:25832782]
55. Ludovic Desvignes,Carl Weidinger,Patrick Shaw,Martin Vaeth,Theo Ribierre,Menghan Liu,Tawania Fergus,Lina Kozhaya,Lauren McVoy,Derya Unutmaz,Joel D Ernst,Stefan Feske. (2015-05-06) STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.. The Journal of clinical investigation, 125 ((6)): (2347-2362). [PMID:25938788]
56. Yael R Nobel,Laura M Cox,Francis F Kirigin,Nicholas A Bokulich,Shingo Yamanishi,Isabel Teitler,Jennifer Chung,Jiho Sohn,Cecily M Barber,David S Goldfarb,Kartik Raju,Sahar Abubucker,Yanjiao Zhou,Victoria E Ruiz,Huilin Li,Makedonka Mitreva,Alexander V Alekseyenko,George M Weinstock,Erica Sodergren,Martin J Blaser. (2015-07-01) Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment.. Nature communications, 6 (7486-7486). [PMID:26123276]
57. Nikita Malhotra,Joseph Abunassar,George A Wells,Ruth McPherson,Angel Fu,Benjamin Hibbert,Marino Labinaz,Michel Le May,Alexander Dick,Chris Glover,Michael Froeschl,Jean-François Marquis,Luan Tran,Jordan Bernick,Aun-Yeong Chong,Derek Y F So. (2015-07-08) A pharmacodynamic comparison of a personalized strategy for anti-platelet therapy versus ticagrelor in achieving a therapeutic window.. International journal of cardiology, 197 (318-325). [PMID:26151596]
58. Ha-Jung Kim,Eun Lee,Seung-Hwa Lee,Mi-Jin Kang,Soo-Jong Hong. (2015-07-25) Mold elicits atopic dermatitis by reactive oxygen species: Epidemiology and mechanism studies.. Clinical immunology (Orlando, Fla.), 161 ((2)): (384-390). [PMID:26205459]
59. Shihoko Kojima,Kerry L Gendreau,Elaine L Sher-Chen,Peng Gao,Carla B Green. (2015-11-21) Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.. Scientific reports, 5 (17059-17059). [PMID:26586468]
60. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486]
61. Yumeng Liao, Nan Zhang, Danni Chai, Boshi Liu, Jingrong Li, Yuting Fang, Di Zhang, Rui Liu, Zheng Li. (2023) Rational design of ratiometric fluorescent aptasensor for patulin in traditional Chinese medicine through the studies of interaction mechanism between DNA aptamer and target molecule. ANALYST, (3): [PMID:37725068]
62. Chen Hu, Caiping Huang, Bangzhu Peng. (2023) Study on the mechanism of photocatalytic degradation of patulin in simulated apple juice. FOOD CHEMISTRY, 426 (136592). [PMID:37354573]
63. Xiaobing Yang, Junjie Pan, Jiapeng Hu, Shengyun Zhao, Kejun Cheng. (2023) MOF-derived La–ZnFe2O4@Fe3O4@carbon magnetic hybrid composite as a highly efficient and recyclable photocatalyst for mycotoxins degradation. CHEMICAL ENGINEERING JOURNAL, 467 (143381). [PMID:]
64. Lei Jiang, Lin Yuan, Shan Gao, Yingying Xiang, Fei Song, Wensi Ma, Jing Wan, Xiuling Ji, Yujiao Tu. (2023) Facile hydrothermal synthesis of N-doped fluorescent carbon dots for selective detection of insecticide parathion. Analytical Methods, 15 (19): (2376-2381). [PMID:37132329]
65. Sai Zhang, Yahui Wang, Qinglin Sheng, Tianli Yue. (2023) Electrochemical Aptasensor Based on ZnO-Au Nanocomposites for the Determination of Ochratoxin A in Wine and Beer. Processes, 11 (3): (864). [PMID:]
66. Dongyan Tian, Jie Wang, Qiandong Zhuang, Songmei Wu, Yu Yu, Kejian Ding. (2023) An electrochemiluminescence biosensor based on Graphitic carbon nitride luminescence quenching for detection of AFB1. FOOD CHEMISTRY, 404 (134183). [PMID:36240563]
67. Hui Chen, Lixing Cao, Kai Han, Han Zhang, Jinling Cui, Xuan Ma, Shuang Zhao, Chong Zhao, Shutao Yin, Lihong Fan, Hongbo Hu. (2022) Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. FOOD AND CHEMICAL TOXICOLOGY, 166 (113255). [PMID:35772596]
68. Lu Yang, Jin Wang, Huan Lv, Xue-Meng Ji, Jing-Min Liu, Shuo Wang. (2022) Hollow-Structured Microporous Organic Networks Adsorbents Enabled Specific and Sensitive Identification and Determination of Aflatoxins. Toxins, 14 (2): (137). [PMID:35202164]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

SKU	Size	Availability	Price
P113515-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$88.90
P113515-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$266.90
P113515-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$890.90

Patulin - 99%, high purity , CAS No.149-29-1