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PB 28 dihydrochloride - >99%, high purity , CAS No.172906-90-0, Agonist of σ2
a high affinity selective σ2 receptor agonist
Basic Description Synonyms PB-28|PB28|172906-90-0|1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine|CHEMBL53325|XTX7Z22467|1-Cyclohexyl-4-(3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl)piperazine|Piperazine, 1-cyclohexyl-4-(3-(1,2,3,4-tetrahyd Specifications & Purity Moligand™, ≥99% Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of σ2 Product Description PB 28 dihydrochloride is a high affinity selective σ2 receptor Activators (K|i|values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. PB 28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum (EC|50|values are 2.62 and 3.96 μM respectively). PB 28 dihydrochloride also displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
Product Properties Ki Data σ2 receptors: Ki= 0.8 nM; σ1 receptors: Ki= 15.2 nM
Names and Identifiers IUPAC Name 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine INCHI InChI=1S/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3 InChi Key PHRCDWVPTULQMT-UHFFFAOYSA-N Canonical SMILES COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4CCCCC4 Isomeric SMILES COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4CCCCC4 WGK Germany 3 Alternate CAS 172906-90-0 PubChem CID 10474335 MeSH Entry Terms 1-cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine;1-cyclohexyl-4-MeOTHN-PrPip Molecular Weight 443.49
Chemical and Physical Properties Solubility Soluble in water (20 mM). Refractive Index n20D~1.54 (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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